https://m2.mtmt.hu/ hun 2026-09-22 12:40 JournalArticle 32040119 VALIDATED true Department of Medical Biochemistry, Semmelweis University, Budapest, 1085, Hungary MTA-SE Lendület Ion Channel Research Group, Semmelweis University, Budapest, 1085, Hungary HCEMM-SE Molecular Channelopathies Research Group, Semmelweis University, Budapest, 1085, Hungary Cited By :2 Export Date: 9 March 2022 Correspondence Address: Szollosi, A.; Department of Medical Biochemistry, Hungary; email: szollosi.andras@med.semmelweis-univ.hu Funding details: 739593 Funding details: LP2017-14/2017 Funding text 1: Supported by MTA Lend?let grant LP2017-14/2017 and EU Horizon 2020 Research and Innovation Program grant 739593. Funding text 2: Funding: Supported by MTA Lendület grant LP2017-14/2017 and EU Horizon 2020 Research and Innovation Program grant 739593. 0 false 2026-06-12T16:06:38.164+0000 2026-04-22T07:12:56.252+0000 2021-05-28T11:27:32.560+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) true 2026-05-22T11:44:33.271+0000 2026-05-22T11:44:33.271+0000 2022-02-24T10:11:51.354+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Szollosi, A. true true /api/journal/10024487 REVIEWED LIFE-BASEL 2075-1729 true false 10024487 false 10024487 true 2075-1729 Journal FOREIGN 11 5 397 397 23 2021 The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions. TRPM2 is a homotetrameric Ca2+-permeable cation channel activated upon oxidative stress and is important, among others, for body heat control, immune cell activation and insulin secretion. Invertebrate TRPM2 proteins are channel enzymes; they hydrolyze the activating ligand, ADP-ribose, which is likely important for functional regulation. Since its cloning in 1998, the understanding of the biophysical properties of the channel has greatly advanced due to a vast number of structure– function studies. The physiological regulators of the channel have been identified and characterized in cell-free systems. In the wake of the recent structural biochemistry revolution, several TRPM2 cryo-EM structures have been published. These structures have helped to understand the general features of the channel, but at the same time have revealed unexplained mechanistic differences among channel orthologues. The present review aims at depicting the major research lines in TRPM2 structure-function. It discusses biophysical properties of the pore and the mode of action of direct channel effectors, and interprets these functional properties on the basis of recent three-dimensional structural models. © 2021 by the author. Licensee MDPI, Basel, Switzerland. Funding 2010102 /api/funding/2010102 (LP2017-14/2017) false true Funding 2010103 /api/funding/2010103 (739593) Támogató: Horizon 2020 false true true 2021 true true true false true false GOLD 2026-06-12 true https://doi.org/10.3390/life11050397 27 0 27 25 6 27 27 24 26 27 27 25 25 25 2 0 27 25 27 25 0 11 11 Folyóiratcikk Journal Article 24 27 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 1 1 1 2022 0 2 2 2 2 2023 0 6 5 6 5 2024 0 6 6 6 6 2025 0 10 9 10 9 2026 0 2 2 2 2 Q2 false 10020191 false false false 2021-05-27T11:33:04.633+0000 Biokémiai Tanszék (SE / AOK / I / BMBI); HCEMM-SE Molekuláris Csatornabetegségek Kutatóc... (SE / AOK / I / BMBI / BT); MTA-SE Lendület Ioncsatorna Kutatócsoport (SE / AOK / I / BMBI / BT) 1 10 3 1 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 96445875 /api/authorship/96445875 Szollosi, A. ✉ [Szöllősi, András (Biokémia), szerző] MTA-SE Lendület Ioncsatorna Kutatócsoport (SE / AOK / I / BMBI / BT); Biokémiai Tanszék (SE / AOK / I / BMBI); HCEMM-SE Molekuláris Csatornabetegségek Kutatóc... (SE / AOK / I / BMBI / BT) 1 1.0 true false true Author 10020191 /api/author/10020191 Szöllősi András (Biokémia) Szöllősi András true 10020191 true Szollosi A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18846969 /api/publicationidentifier/18846969 DOI: 10.3390/life11050397 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/life11050397 https://doi.org/10.3390/life11050397 false true PublicationIdentifier 18926098 /api/publicationidentifier/18926098 WoS: 000654116000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000654116000001 https://www.webofscience.com/wos/woscc/full-record/000654116000001 true true PublicationIdentifier 18846968 /api/publicationidentifier/18846968 Scopus: 85105782082 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85105782082 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105782082 false true PublicationIdentifier 18926107 /api/publicationidentifier/18926107 PubMed: 33925466 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33925466 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33925466&dopt=Abstract false true PublicationIdentifier 31874235 /api/publicationidentifier/31874235 Egyéb URL: https://www.scopus.com/pages/publications/85105782082?origin=resultslist PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/pages/publications/85105782082?origin=resultslist https://www.scopus.com/pages/publications/85105782082?origin=resultslist false true Keyword 2282 /api/keyword/2282 ION CHANNELS true 2282 true Keyword 1014845 /api/keyword/1014845 ADP-ribose true 1014845 true Keyword 1507502 /api/keyword/1507502 Single particle cryo-EM true true Keyword 1533642 /api/keyword/1533642 TRPM2 true true Keyword 1711741 /api/keyword/1711741 Nudix hydrolase true true SjrRating 11195856 /api/sjrrating/11195856 sjr:Q2 (2021) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) LIFE-BASEL 2075-1729 102 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true Q2 DIRECT true true Reference 20866278 /api/reference/20866278 1. 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(2021) LIFE-BASEL 2075-1729 11 5<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020191"><a href="/gui2/?type=authors&mode=browse&sel=10020191" target="_blank">Szollosi A. ✉ (<span class="authorship-author-name">Szöllősi András</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Biokémiai Tanszék">BT</span>/MTA-SE Lendület Ioncsatorna Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Biokémiai Tanszék">BT</span>/HCEMM-SE Molekuláris Csatornabetegségek Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32040119" target="_blank">Two decades of evolution of our understanding of the transient receptor potential melastatin 2 (Trpm2) cation channel</a></div> <div> <span class="journal-title">LIFE-BASEL</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2075-1729">2075-1729</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">5</span> <span class="page"> Paper 397. 23 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/life11050397" target="_blank" href="https://doi.org/10.3390/life11050397"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000654116000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000654116000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85105782082" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105782082"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33925466" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33925466&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85105782082?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85105782082?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ecology, Evolution, Behavior and Systematics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Paleontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Space and Planetary Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 27</span> | Független: 25 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 24 | Scopus jelölt:&nbsp;26 | WoS/Scopus jelölt:&nbsp;27 | DOI jelölt:&nbsp;27 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32040119&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32040119</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (LP2017-14/2017), HCEMM(739593) Támogató: Horizon 2020 </div> <div class="lastModified">Utolsó módosítás: 2026.04.22. 09:12 Kajtár Virág Anna (SE_AOK_Biokemia_Admin5_KV, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Medical Biochemistry, Semmelweis University, Budapest, 1085, Hungary MTA-SE Lendület Ion Channel Research Group, Semmelweis University, Budapest, 1085, Hungary HCEMM-SE Molecular Channelopathies Research Group, Semmelweis University, Budapest, 1085, Hungary Cited By :2 Export Date: 9 Ma...</pre> </div></div>