https://m2.mtmt.hu/ hun 2026-04-17 15:17 JournalArticle 32039266 VALIDATED true 0 false 2026-04-07T11:34:03.995+0000 2023-10-03T21:19:30.764+0000 2021-05-28T06:30:48.610+0000 true 10030409 Karikó Katalin /api/author/10030409 Author Karikó Katalin (biofizika) true 10030409 2023-10-03T21:19:21.921+0000 2023-10-03T21:19:21.921+0000 2023-10-03T21:19:31.163+0000 true 10018695 Bernátskyné Babus Csilla /api/admin/10018695 Admin Bernátskyné Babus Csilla (SZTE admin4) true 10018695 Admin 10058227 /api/admin/10058227 Áts József (ÁtsJ adm2-3, admin) Áts József true 10058227 true 2023-11-06T07:03:17.841+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Karikó, K. true true /api/journal/2295 REVIEWED JOURNAL OF BIOLOGICAL CHEMISTRY 0021-9258 1083-351X true false 2295 false 2295 true 0021-9258 1083-351X Journal FOREIGN 279 13 12542 12550 12542 9 2004 Toll-like receptors (TLRs) are the basic signaling receptors of the innate immune system. They are activated by molecules associated with pathogens or injured host cells and tissue. TLR3 has been shown to respond to double stranded (ds) RNA, a replication intermediary for many viruses. Here we present evidence that heterologous RNA released from or associated with necrotic cells or generated by in vitro transcription also stimulates TLR3 and induces immune activation. To assess RNA-mediated TLR3 activation, human embryonic kidney 293 cells stably expressing TLR3 and containing a nuclear factor-κB-dependent luciferase reporter were generated. Exposing these cells to in vitro transcribed RNA resulted in a TLR3-dependent induction of luciferase activity and interleukin-8 secretion. Treatment with in vitro transcribed mRNA activated nuclear factor-κB via TLR3 through a process that was dose-dependent and involved tyrosine phosphorylation. Furthermore, in vitro transcribed natural or 2′-fluoro-substituted mRNA induced the expression of TLR3, interferon regulatory factor-1, tumor necrosis factor-α, and interleukin-1 receptor-associated kinase-M mRNA in human dendritic cells (DCs). DCs responded to mRNA treatment by expressing activation markers, and this maturation was inhibited by antagonistic TLR3-specific antibody. Endogenous RNA released from or associated with necrotic cells also stimulated DCs, leading to interferon-α secretion, which could be abolished by pretreatment of necrotic cells with RNase. These results demonstrate that RNA, likely through secondary structure, is a potent host-derived activator of TLR3. This finding has potential physiologic relevance because RNA escaping from damaged tissue or contained within endocytosed cells could serve as an endogenous ligand for TLR3 that induces or otherwise modulates immune responses. 2021 true true true false false NONE 2026-04-07 false 983 1 983 970 4 978 946 934 897 982 982 969 969 970 12 1 983 970 983 970 1 3 3 Folyóiratcikk Journal Article 24 923 Könyvrészlet Chapter in Book 25 55 Könyv Book 23 5 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2004 0 11 9 11 9 2005 0 42 41 42 41 2006 0 59 59 59 59 2007 0 46 45 46 45 2008 0 57 55 57 55 2009 0 53 53 53 53 2010 0 49 49 49 49 2011 0 52 51 52 51 2012 0 63 62 63 62 2013 0 52 52 52 52 2014 0 46 46 46 46 2015 0 41 41 41 41 2016 0 41 41 41 41 2017 0 42 42 42 42 2018 0 47 47 47 47 2019 0 31 31 31 31 2020 0 33 33 33 33 2021 0 50 50 50 50 2022 0 46 44 46 44 2023 0 50 49 50 49 2024 0 35 34 35 34 2025 0 35 34 35 34 2026 0 2 2 2 2 D1 false 10030409 false false false 2021-08-26T08:08:11.230+0000 1 6 0 5 0 true 10058227 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 96439177 /api/authorship/96439177 Karikó, K. ✉ [Karikó, Katalin (biofizika), szerző] 1 0.2 true false true Author 10030409 /api/author/10030409 Karikó Katalin (biofizika) Karikó Katalin true 10030409 true Karikó K. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96439178 /api/authorship/96439178 Ni, H. 2 0.2 false false false Ni H. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96439179 /api/authorship/96439179 Capodici, J. 3 0.2 false false false Capodici J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96439180 /api/authorship/96439180 Lamphier, M. 4 0.2 false false false Lamphier M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96439181 /api/authorship/96439181 Weissman, D. 5 0.2 false true false Weissman D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18844516 /api/publicationidentifier/18844516 DOI: 10.1074/jbc.M310175200 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1074/jbc.M310175200 https://doi.org/10.1074/jbc.M310175200 false true PublicationIdentifier 18844517 /api/publicationidentifier/18844517 WoS: 000220334900066 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000220334900066 https://www.webofscience.com/wos/woscc/full-record/000220334900066 false true PublicationIdentifier 18844515 /api/publicationidentifier/18844515 Scopus: 1842477469 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 1842477469 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-1842477469 false true PublicationIdentifier 18844641 /api/publicationidentifier/18844641 PubMed: 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/api/keyword/3075 Tumor necrosis factor-alpha true 3075 true Keyword 3076 /api/keyword/3076 Toll-Like Receptors true 3076 true Keyword 3090 /api/keyword/3090 immunology true 3090 true Keyword 3122 /api/keyword/3122 human true 3122 true Keyword 4019 /api/keyword/4019 Up-Regulation true 4019 true Keyword 4041 /api/keyword/4041 Enzyme-Linked Immunosorbent Assay true 4041 true Keyword 4600 /api/keyword/4600 priority journal true 4600 true Keyword 4608 /api/keyword/4608 controlled study true 4608 true Keyword 4651 /api/keyword/4651 GENISTEIN true 4651 true Keyword 4878 /api/keyword/4878 Dose-Response Relationship, Drug true 4878 true Keyword 5079 /api/keyword/5079 nonhuman true 5079 true Keyword 5088 /api/keyword/5088 animal cell true 5088 true Keyword 5485 /api/keyword/5485 Animalia true 5485 true Keyword 6662 /api/keyword/6662 protein phosphorylation true 6662 true Keyword 6711 /api/keyword/6711 Enzyme Inhibitors true 6711 true Keyword 6869 /api/keyword/6869 immune system true 6869 true Keyword 7416 /api/keyword/7416 Plasmids true 7416 true Keyword 7437 /api/keyword/7437 Nucleic Acid Conformation true 7437 true Keyword 7685 /api/keyword/7685 Blotting, Northern true 7685 true Keyword 8048 /api/keyword/8048 Transfection true 8048 true Keyword 8067 /api/keyword/8067 Cell Line true 8067 true Keyword 8091 /api/keyword/8091 Transcription, Genetic true 8091 true Keyword 13979 /api/keyword/13979 human cell true 13979 true Keyword 14327 /api/keyword/14327 T lymphocyte activation true 14327 true Keyword 14547 /api/keyword/14547 Tumor Necrosis Factor true 14547 true Keyword 14574 /api/keyword/14574 RNA, Messenger true 14574 true Keyword 14579 /api/keyword/14579 messenger rna true 14579 true Keyword 14709 /api/keyword/14709 host resistance true 14709 true Keyword 14974 /api/keyword/14974 immune response true 14974 true Keyword 18422 /api/keyword/18422 tyrosine true 18422 true Keyword 1000537 /api/keyword/1000537 VIRUSES true 1000537 true Keyword 1004659 /api/keyword/1004659 PATHOGENS true 1004659 true Keyword 1005199 /api/keyword/1005199 BIOCHEMISTRY true 1005199 true Keyword 1006723 /api/keyword/1006723 NF-kappa B true 1006723 true Keyword 1006731 /api/keyword/1006731 immunoglobulin enhancer binding protein true 1006731 true Keyword 1008080 /api/keyword/1008080 protein kinases true 1008080 true Keyword 1010323 /api/keyword/1010323 Staurosporine true 1010323 true Keyword 1013311 /api/keyword/1013311 Membrane Glycoproteins true 1013311 true Keyword 1014810 /api/keyword/1014810 Dendritic cell true 1014810 true Keyword 1016134 /api/keyword/1016134 transcription regulation true 1016134 true Keyword 1018156 /api/keyword/1018156 antigen presenting cell true 1018156 true Keyword 1018650 /api/keyword/1018650 enzyme kinetics true 1018650 true Keyword 1027991 /api/keyword/1027991 interleukin 1 true 1027991 true Keyword 1028949 /api/keyword/1028949 Receptors, Cell Surface true 1028949 true Keyword 1032158 /api/keyword/1032158 Luciferases true 1032158 true Keyword 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(2004) JOURNAL OF BIOLOGICAL CHEMISTRY 0021-9258 1083-351X 279 13 12542-12550<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10030409"><a href="/gui2/?type=authors&mode=browse&sel=10030409" target="_blank">Karikó K. ✉ (<span class="authorship-author-name">Karikó Katalin</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ni H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Capodici J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lamphier M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weissman D. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32039266" target="_blank">mRNA Is an Endogenous Ligand for Toll-like Receptor 3</a></div> <div> <span class="journal-title">JOURNAL OF BIOLOGICAL CHEMISTRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0021-9258">0021-9258</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1083-351X">1083-351X</a>)</span>: <span class="journal-volume">279</span> <span class="journal-issue">13</span> <span class="page"> pp 12542-12550 </span> <span class="year">(2004)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1074/jbc.M310175200" target="_blank" href="https://doi.org/10.1074/jbc.M310175200"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000220334900066" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000220334900066"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="1842477469" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-1842477469"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="14729660" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14729660&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 983</span> | Független: 970 | Függő: 12 | Nem jelölt: 1 | WoS jelölt: 934 | Scopus jelölt:&nbsp;897 | WoS/Scopus jelölt:&nbsp;982 | DOI jelölt:&nbsp;946 (Nem nyilvános:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32039266&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32039266</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2023.10.03. 23:19 Bernátskyné Babus Csilla (SZTE admin4) </div> <div class="lockedBy">Központi kezelésű 2023.11.06. 08:03 Áts József (ÁtsJ adm2-3, admin) </div> </div></div>