https://m2.mtmt.hu/ eng 2026-10-23 19:25 JournalArticle 32029268 VALIDATED true Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary Hereditary Tumours Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary Cited By :8 Export Date: 13 December 2023 CODEN: POREF Correspondence Address: Butz, H.; Department of Laboratory Medicine, Hungary; email: butz.henriett@med.semmelweis-univ.hu Chemicals/CAS: matrigel, 119978-18-6 0 false 2026-10-21T09:07:23.203+0000 2022-10-11T09:17:31.114+0000 2021-05-21T09:09:53.596+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Anna Sághi-Keszthelyi (SE_KK_Admin5_SKA, admin) true 2025-07-30T11:56:58.089+0000 2022-10-11T09:17:31.372+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Tamásné Gere (SE_KK_Admin5_GT, admin) true 10062062 Admin 10003134 /api/admin/10003134 György Wolf (MTMT Központi admin) Wolf György true 10003134 true 2024-04-11T07:19:53.187+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Krokker, L. true true /api/journal/1035680 REVIEWED PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 27 640676 640676 10 2021 In vitro monolayer conditions are not able to reproduce the complexity of solid tumors, still, there is scarce information about the 3D cell culture models of endocrine tumor types. Therefore, our aim was to develop in vitro 3D tumor models by different methodologies for adrenocortical carcinoma (H295R), pituitary neuroendocrine tumor (RC-4B/C and GH3) and pheochromocytoma (PC-12). Various methodologies were tested. Cell biological assays (cell viability, proliferation and live cell ratio) and steroid hormone production by HPLC-MS/MS method were applied to monitor cellular well-being. Cells in hanging drops and embedded in matrigel formed multicellular aggregates but they were difficult to handle and propagate for further experiments. The most widely used methods: ultra-low attachment plate (ULA) and spheroid inducing media (SFDM) were not the most viable 3D model of RC-4B/C and GH3 cells that would be suitable for further experiments. Combining spheroid generation with matrigel scaffold H295R 3D models were viable for 7 days, RC-4B/C and GH3 3D models for 7–10 days. ULA and SFDM 3D models of PC-12 cells could be used for further experiments up to 4 days. Higher steroid production in 3D models compared to conventional monolayer culture was detected. Endocrine tumor cells require extracellular matrix as scaffold for viable 3D models that can be one reason behind the lack of the usage of endocrine 3D cultures. Our models help understanding the pathogenesis of endocrine tumors and revealing potential biomarkers and therapeutic targets. They could also serve as an excellent platform for preclinical drug test screening. © Copyright © 2021 Krokker, Szabó, Németh, Tóháti, Sarkadi, Mészáros, Patócs and Butz. Funding 2009813 /api/funding/2009813 (STIA-KF-19) false true Funding 2009814 /api/funding/2009814 (NKFI FK 135065) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true Funding 2009815 /api/funding/2009815 (ÚNKP-19-4- SE-15) false true Funding 2009816 /api/funding/2009816 (Janos Bolyai Research Fellowship) Funder: MTA Bolyai pályázat false true Funding 2009817 /api/funding/2009817 (K125231) Funder: NRDIO false true Funding 2009818 /api/funding/2009818 (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University) false true true true 2021 true true true false true false NONE 2026-10-21 false 13 0 13 11 2 13 13 11 13 13 13 11 11 11 2 0 13 11 13 11 0 4 4 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 1 1 1 2022 0 1 1 1 1 2023 0 6 5 6 5 2024 0 3 3 3 3 2025 0 2 1 2 1 Q2 false false false false 2021-05-20T09:41:32.437+0000 Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Lendület Örökletes Endokrin Daganatok Ku... (SE / AOK / K / IISZBK); MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT); Országos Onkológiai Intézet 7 17 4 8 0 true 10003134 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 96371597 /api/authorship/96371597 Krokker, L. [Krokker, Lilla (Orvostudomány), author] Department of Laboratory Medicine (SU / FM / I); "Lendület" MTA-SE Research Group for Hereditary... (SU / FM / C / IIDIM) 1 0.125 true false false Author 10071844 /api/author/10071844 Lilla Krokker (Orvostudomány) Krokker Lilla true true Krokker L. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96371598 /api/authorship/96371598 Szabó, B.* [Szabó, Borbála (Endokrinológia), author] Department of Laboratory Medicine (SU / FM / I); MTA-SE Research Group for Hereditary Tumors (SU / FM / I / DLM) 2 0.125 true false false Author 10065387 /api/author/10065387 Borbála Szabó (Endokrinológia) Szabó Borbála true true Szabó B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96371599 /api/authorship/96371599 Németh, K. [Németh, Kinga (orvostudományok), author] "Lendület" MTA-SE Research Group for Hereditary... (SU / FM / C / IIDIM) 3 0.125 false false false Author 10052152 /api/author/10052152 Kinga Németh (orvostudományok) Németh Kinga true 10052152 true Németh K. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96371600 /api/authorship/96371600 Tóháti, R. 4 0.125 false false false Tóháti R. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96371601 /api/authorship/96371601 Sarkadi, B. [Sarkadi, Balázs (klinikai orvostud...), author] MTA-SE Research Group for Hereditary Tumors (SU / FM / I / DLM) 5 0.125 false false false Author 10057384 /api/author/10057384 Balázs Sarkadi (klinikai orvostudományok) Sarkadi Balázs true 10057384 true Sarkadi B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96371602 /api/authorship/96371602 Mészáros, K. [Mészáros, Katalin (orvosi laboratóri...), author] MTA-SE Research Group for Hereditary Tumors (SU / FM / I / DLM) 6 0.125 false false false Author 10058121 /api/author/10058121 Katalin Mészáros (orvosi laboratóriumi diagnosztika) Mészáros Katalin true 10058121 true Mészáros K. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96371603 /api/authorship/96371603 Patócs, A. [Patócs, Attila Balázs (Orvostudomány), author] National Institute of Oncology; Department of Laboratory Medicine (SU / FM / I); MTA-SE Research Group for Hereditary Tumors (SU / FM / I / DLM) 7 0.125 false false false Author 10001006 /api/author/10001006 Attila Balázs Patócs (Orvostudomány) Patócs Attila Balázs true 10001006 true Patócs A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 96371604 /api/authorship/96371604 Butz, H. ✉ [Butz, Henriett (orvostudomány), author] National Institute of Oncology; Department of Laboratory Medicine (SU / FM / I); MTA-SE Research Group for Hereditary Tumors (SU / FM / I / DLM) 8 0.125 false true true Author 10020420 /api/author/10020420 Henriett Butz (orvostudomány) Butz Henriett true 10020420 true Butz H. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 18822335 /api/publicationidentifier/18822335 DOI: 10.3389/pore.2021.640676 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3389/pore.2021.640676 https://doi.org/10.3389/pore.2021.640676 false true PublicationIdentifier 18848051 /api/publicationidentifier/18848051 WoS: 000646936700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000646936700001 https://www.webofscience.com/wos/woscc/full-record/000646936700001 false true PublicationIdentifier 18822334 /api/publicationidentifier/18822334 Scopus: 85105275232 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85105275232 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105275232 false true PublicationIdentifier 20432573 /api/publicationidentifier/20432573 PubMed: 34257605 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34257605 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34257605&dopt=Abstract false true Keyword 1052850 /api/keyword/1052850 adrenal tumor true 1052850 true Keyword 1056340 /api/keyword/1056340 pheochromocytoma true 1056340 true Keyword 1156149 /api/keyword/1156149 pituitary adenoma true 1156149 true Keyword 1493558 /api/keyword/1493558 ADRENOCORTICAL CARCINOMA true true Keyword 1542054 /api/keyword/1542054 3D cell culture true true Keyword 1745978 /api/keyword/1745978 PitNet true true SjrRating 11225850 /api/sjrrating/11225850 sjr:Q2 (2021) Scopus - Medicine (miscellaneous) PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 968 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q2 DIRECT true true Reference 20722493 /api/reference/20722493 1. Tischler, A.S., deKrijger, R.R., 15 YEARS of PARAGANGLIOMA: Pathology of Pheochromocytoma and Paraganglioma (2015) Endocr Relat Cancer, 22, pp. T123-T133 1 false true Reference 20722492 /api/reference/20722492 2. Jimenez, C., Treatment for Patients with Malignant Pheochromocytomas and Paragangliomas: A Perspective from the Hallmarks of Cancer (2018) Front Endocrinol, 9, p. 277 2 false true Reference 20722491 /api/reference/20722491 3. Igaz, P., Igaz, I., Nagy, Z., Nyírő, G., Szabó, P.M., Falus, A., MicroRNAs in Adrenal Tumors: Relevance for Pathogenesis, Diagnosis, and Therapy (2015) Cell. Mol. Life Sci, 72, pp. 417-428 3 false true Reference 20722490 /api/reference/20722490 4. Galan, S.R., Kann, P.H., Genetics and Molecular Pathogenesis of Pheochromocytoma and Paraganglioma (2013) Clin Endocrinol, 78, pp. 165-175 4 false true Reference 20722489 /api/reference/20722489 5. Jimenez, C., Rohren, E., Habra, M.A., Rich, T., Jimenez, P., Ayala-Ramirez, M., Current and Future Treatments for Malignant Pheochromocytoma and Sympathetic Paraganglioma (2013) Curr Oncol Rep, 15, pp. 356-371 5 false true Reference 20722488 /api/reference/20722488 6. discussion 962-963 6 false true Reference 20722487 /api/reference/20722487 7. Safford, S.D., Coleman, R.E., Gockerman, J.P., Moore, J., Feldman, J.M., Leight, G.S., Iodine -131 Metaiodobenzylguanidine Is an Effective Treatment for Malignant Pheochromocytoma and Paraganglioma (2003) Surgery, 134, p. 956. , 62 7 false true Reference 20722486 /api/reference/20722486 8. Baek, N., Seo, O.W., Lee, J., Hulme, J., An, S.S., Real-time Monitoring of Cisplatin Cytotoxicity on Three-Dimensional Spheroid Tumor Cells (2016) Drug Des Devel Ther, 10, pp. 2155-2165 8 false true Reference 20722485 /api/reference/20722485 9. Marques, P., Korbonits, M., Genetic Aspects of Pituitary Adenomas (2017) Endocrinol Metab Clin North America, 46, pp. 335-374 9 false true Reference 20722484 /api/reference/20722484 10. Dai, C., Liu, X., Ma, W., Wang, R., The Treatment of Refractory Pituitary Adenomas (2019) Front Endocrinol, 10, p. 334 10 false true Reference 20722483 /api/reference/20722483 11. Lichtenauer, U.D., Shapiro, I., Osswald, A., Meurer, S., Kulle, A., Reincke, M., Characterization of NCI-H295r Cells as an In Vitro Model of Hyperaldosteronism (2013) Horm Metab Res, 45, pp. 124-129 11 false true Reference 20722482 /api/reference/20722482 12. Else, T., Kim, A.C., Sabolch, A., Raymond, V.M., Kandathil, A., Caoili, E.M., Adrenocortical Carcinoma (2014) Endocr Rev, 35, pp. 282-326 12 false true Reference 20722481 /api/reference/20722481 13. Megerle, F., Herrmann, W., Schloetelburg, W., Ronchi, C.L., Pulzer, A., Quinkler, M., Mitotane Monotherapy in Patients with Advanced Adrenocortical Carcinoma (2018) J Clin Endocrinol Metab, 103, pp. 1686-1695 13 false true Reference 20722480 /api/reference/20722480 14. Basu, B., Sirohi, B., Corrie, P., Systemic Therapy for Neuroendocrine Tumours of Gastroenteropancreatic Origin (2010) Endocr Relat Cancer, 17, pp. R75-R90 14 false true Reference 20722479 /api/reference/20722479 15. Langhans, S.A., Three-Dimensional In Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018) Front Pharmacol, 9, p. 6 15 false true Reference 20722478 /api/reference/20722478 16. Mészáros, K., Karvaly, G., Márta, Z., Magda, B., Tőke, J., Szücs, N., Diagnostic Performance of a Newly Developed Salivary Cortisol and Cortisone Measurement Using an LC-MS/MS Method with Simple and Rapid Sample Preparation (2018) J Endocrinol Invest, 41, pp. 315-323 16 false true Reference 20722477 /api/reference/20722477 17. Gaillard, I., Prugnard, E., Brand, C., Chambaz, E., Vilgrain, I., [Interactions between Steroidogenic Cells and Capillary Endothelial Cells in the Adrenal Gland] (1999) Pathol Biol (Paris), 47, pp. 314-321 17 false true Reference 20722476 /api/reference/20722476 18. Mallet, C., Féraud, O., Ouengue-Mbélé, G., Gaillard, I., Sappay, N., Vittet, D., Differential Expression of VEGF Receptors in Adrenal Atrophy Induced by Dexamethasone: a Protective Role of ACTH (2003) Am J Physiology-Endocrinology Metab, 284, pp. E156-E167 18 false true Reference 20722475 /api/reference/20722475 19. Zhang, F., Lin, H., Cao, K., Wang, H., Pan, J., Zhuang, J., Vasculogenic Mimicry Plays an Important Role in Adrenocortical Carcinoma (2016) Int J Urol, 23, pp. 371-377 19 false true Reference 20722474 /api/reference/20722474 20. Balyura, M., Gelfgat, E., Ehrhart-Bornstein, M., Ludwig, B., Gendler, Z., Barkai, U., Transplantation of Bovine Adrenocortical Cells Encapsulated in Alginate (2015) Proc Natl Acad Sci USA, 112, pp. 2527-2532 20 false true Reference 20722473 /api/reference/20722473 21. Tsukada, T., Fujiwara, K., Horiguchi, K., Azuma, M., Ramadhani, D., Tofrizal, A., Folliculostellate Cells Are Required for Laminin Release from Gonadotrophs in Rat Anterior Pituitary (2014) Acta Histochem Cytochem, 47, pp. 239-245 21 false true Reference 20722472 /api/reference/20722472 22. Diao, J., Zhang, C., Zhang, D., Role and Mechanisms of a Three-Dimensional Bioprinted Microtissue Model in Promoting Proliferation and Invasion of Growth-Hormone-Secreting Pituitary Adenoma Cells (2019) Biofabrication, 11, p. 025006 22 false true Reference 20722471 /api/reference/20722471 23. Tsukada, T., Kouki, T., Fujiwara, K., Ramadhani, D., Horiguchi, K., Kikuchi, M., Reassembly of Anterior Pituitary Organization by Hanging Drop Three-Dimensional Cell Culture (2013) Acta Histochem Cytochem, 46, pp. 121-127 23 false true Reference 20722470 /api/reference/20722470 24. Ozone, C., Suga, H., Functional Pituitary Tissue Formation (2017) Methods Mol Biol Clifton NJ, 1597, pp. 57-65 24 false true Reference 20722469 /api/reference/20722469 25. Jin, L., Feng, Z.-Q., Zhu, M.-L., Wang, T., Leach, M.K., Jiang, Q., A Novel Fluffy Conductive Polypyrrole Nano-Layer Coated PLLA Fibrous Scaffold for Nerve Tissue Engineering (2012) J Biomed Nanotechnology, 8, pp. 779-785 25 false true Reference 20722468 /api/reference/20722468 26. Erndt-Marino, J.D., Hahn, M.S., Probing the Response of Human Osteoblasts Following Exposure to Sympathetic Neuron-like PC-12 Cells in a 3D Coculture Model (2017) J Biomed Mater Res, 105, pp. 984-990 26 false true Reference 20722467 /api/reference/20722467 27. D’Antongiovanni, V., Martinelli, S., Richter, S., The Microenvironment Induces Collective Migration in SDHB-Silenced Mouse Pheochromocytoma Spheroids (2017) Endocr Relat Cancer, 24, pp. 555-564 27 false true Reference 20722466 /api/reference/20722466 28. Sarkadi, B., Meszaros, K., Krencz, I., Canu, L., Krokker, L., Zakarias, S., Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas (2020) Cancers, 12, p. 599 28 false true Reference 20722465 /api/reference/20722465 29. Otoukesh, S., Cooper, C.J., Lou, W., Mojtahedzadeh, M., Nasrazadani, A., Wampler, M., Combination Chemotherapy Regimen in a Patient with Metastatic Malignant Pheochromocytoma and Neurofibromatosis Type 1 (2014) Am J Case Rep, 15, pp. 123-127 29 false true Reference 20722464 /api/reference/20722464 30. Chan, D.L., Singh, S., Current Chemotherapy Use in Neuroendocrine Tumors (2018) Endocrinol Metab Clin North America, 47, pp. 603-614 30 false true Reference 20722463 /api/reference/20722463 31. Hallanger-Johnson, J.E., Systemic Therapy for Adrenocortical Carcinoma: a Review (2020) AME Med J, 5, p. 5 31 false true Reference 20722462 /api/reference/20722462 32. Nietzer, S., Baur, F., Sieber, S., Hansmann, J., Schwarz, T., Stoffer, C., Mimicking Metastases Including Tumor Stroma: A New Technique to Generate a Three-Dimensional Colorectal Cancer Model Based on a Biological Decellularized Intestinal Scaffold (2016) Tissue Eng C: Methods, 22, pp. 621-635 32 false true Reference 20722461 /api/reference/20722461 33. Jo, Y., Choi, N., Kim, K., Koo, H.-J., Choi, J., Kim, H.N., Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-Mimicking In Vitro Models in Anti-cancer Drug Development (2018) Theranostics, 8, pp. 5259-5275 33 false true Reference 20722460 /api/reference/20722460 34. Lv, D., Hu, Z., Lu, L., Lu, H., Xu, X., Three-dimensional Cell Culture: A Powerful Tool in Tumor Research and Drug Discovery (2017) Oncol Lett, 14, pp. 6999-7010 34 false true Reference 20722459 /api/reference/20722459 35. Costa, E.C., Moreira, A.F., de Melo-Diogo, D., Gaspar, V.M., Carvalho, M.P., Correia, I.J., 3D Tumor Spheroids: an Overview on the Tools and Techniques Used for Their Analysis (2016) Biotechnol Adv, 34, pp. 1427-1441 35 false true Reference 20722458 /api/reference/20722458 36. Ravi, M., Ramesh, A., Pattabhi, A., Contributions of 3D Cell Cultures for Cancer Research (2017) J Cel Physiol, 232, pp. 2679-2697 36 false true /api/publication/32029268 Krokker L. et al. Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors. (2021) PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 27<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071844"><a href="/gui2/?type=authors&mode=browse&sel=10071844" target="_blank">Krokker L. (<span class="authorship-author-name">Krokker Lilla</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="II. Department of Internal Medicine">IIDIM</span>/"Lendület" MTA-SE Research Group for Hereditary Endocrine Tumors</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065387"><a href="/gui2/?type=authors&mode=browse&sel=10065387" target="_blank">Szabó B.^* (<span class="authorship-author-name">Szabó Borbála</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Laboratory Medicine">DLM</span>/MTA-SE Research Group for Hereditary Tumors</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052152"><a href="/gui2/?type=authors&mode=browse&sel=10052152" target="_blank">Németh K. (<span class="authorship-author-name">Németh Kinga</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="II. Department of Internal Medicine">IIDIM</span>/"Lendület" MTA-SE Research Group for Hereditary Endocrine Tumors</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tóháti R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057384"><a href="/gui2/?type=authors&mode=browse&sel=10057384" target="_blank">Sarkadi B. (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> klinikai orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Laboratory Medicine">DLM</span>/MTA-SE Research Group for Hereditary Tumors</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058121"><a href="/gui2/?type=authors&mode=browse&sel=10058121" target="_blank">Mészáros K. (<span class="authorship-author-name">Mészáros Katalin</span> <span class="authorAux-mtmt"> orvosi laboratóriumi diagnosztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Laboratory Medicine">DLM</span>/MTA-SE Research Group for Hereditary Tumors</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001006"><a href="/gui2/?type=authors&mode=browse&sel=10001006" target="_blank">Patócs A. (<span class="authorship-author-name">Patócs Attila Balázs</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Laboratory Medicine">DLM</span>/MTA-SE Research Group for Hereditary Tumors</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020420"><a href="/gui2/?type=authors&mode=browse&sel=10020420" target="_blank">Butz H. ✉ (<span class="authorship-author-name">Butz Henriett</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Laboratory Medicine">DLM</span>/MTA-SE Research Group for Hereditary Tumors</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32029268" target="_blank">Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">27</span> <span class="page"> Paper 640676. 10 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/pore.2021.640676" target="_blank" href="https://doi.org/10.3389/pore.2021.640676"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000646936700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000646936700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85105275232" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105275232"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34257605" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34257605&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 11 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus:&nbsp;13 | WoS/Scopus assigned:&nbsp;13 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32029268&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32029268</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (STIA-KF-19), (NKFI FK 135065) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (ÚNKP-19-4- SE-15), (Janos Bolyai Research Fellowship) Funder: MTA Bolyai pályázat, (K125231) Funder: NRDIO, (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University) </div> <div class="lastModified">Last Modified: 2022.10.11. 11:17 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Centrally managed 2024.04.11. 09:19 György Wolf (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary Hereditary Tumours Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary Cited By :8 Export Date: 13 Dec...</pre> </div></div>