https://m2.mtmt.hu/ hun 2026-09-20 14:41 JournalArticle 32029268 VALIDATED true Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary Hereditary Tumours Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary Cited By :8 Export Date: 13 December 2023 CODEN: POREF Correspondence Address: Butz, H.; Department of Laboratory Medicine, Hungary; email: butz.henriett@med.semmelweis-univ.hu Chemicals/CAS: matrigel, 119978-18-6 0 false 2026-09-09T06:14:03.796+0000 2022-10-11T09:17:31.114+0000 2021-05-21T09:09:53.596+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) true 2025-07-30T11:56:58.089+0000 2022-10-11T09:17:31.372+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 Admin 10003134 /api/admin/10003134 Wolf György (MTMT Központi admin) Wolf György true 10003134 true 2024-04-11T07:19:53.187+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Krokker, L. true true /api/journal/1035680 REVIEWED PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 27 640676 640676 10 2021 In vitro monolayer conditions are not able to reproduce the complexity of solid tumors, still, there is scarce information about the 3D cell culture models of endocrine tumor types. Therefore, our aim was to develop in vitro 3D tumor models by different methodologies for adrenocortical carcinoma (H295R), pituitary neuroendocrine tumor (RC-4B/C and GH3) and pheochromocytoma (PC-12). Various methodologies were tested. Cell biological assays (cell viability, proliferation and live cell ratio) and steroid hormone production by HPLC-MS/MS method were applied to monitor cellular well-being. Cells in hanging drops and embedded in matrigel formed multicellular aggregates but they were difficult to handle and propagate for further experiments. The most widely used methods: ultra-low attachment plate (ULA) and spheroid inducing media (SFDM) were not the most viable 3D model of RC-4B/C and GH3 cells that would be suitable for further experiments. Combining spheroid generation with matrigel scaffold H295R 3D models were viable for 7 days, RC-4B/C and GH3 3D models for 7–10 days. ULA and SFDM 3D models of PC-12 cells could be used for further experiments up to 4 days. Higher steroid production in 3D models compared to conventional monolayer culture was detected. Endocrine tumor cells require extracellular matrix as scaffold for viable 3D models that can be one reason behind the lack of the usage of endocrine 3D cultures. Our models help understanding the pathogenesis of endocrine tumors and revealing potential biomarkers and therapeutic targets. They could also serve as an excellent platform for preclinical drug test screening. © Copyright © 2021 Krokker, Szabó, Németh, Tóháti, Sarkadi, Mészáros, Patócs and Butz. Funding 2009813 /api/funding/2009813 (STIA-KF-19) false true Funding 2009814 /api/funding/2009814 (NKFI FK 135065) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true Funding 2009815 /api/funding/2009815 (ÚNKP-19-4- SE-15) false true Funding 2009816 /api/funding/2009816 (Janos Bolyai Research Fellowship) Támogató: MTA Bolyai pályázat false true Funding 2009817 /api/funding/2009817 (K125231) Támogató: NKFIH false true Funding 2009818 /api/funding/2009818 (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University) false true true true 2021 true true true false true false NONE 2026-09-09 false 13 0 13 11 2 13 13 11 13 13 13 11 11 11 2 0 13 11 13 11 0 4 4 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 1 1 1 2022 0 1 1 1 1 2023 0 6 5 6 5 2024 0 3 3 3 3 2025 0 2 1 2 1 Q2 false false false false 2021-05-20T09:41:32.437+0000 Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Lendület Örökletes Endokrin Daganatok Ku... (SE / AOK / K / IISZBK); MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT); Országos Onkológiai Intézet 7 17 4 8 0 true 10003134 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 96371597 /api/authorship/96371597 Krokker, L. [Krokker, Lilla (Orvostudomány), szerző] Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Lendület Örökletes Endokrin Daganatok Ku... (SE / AOK / K / IISZBK) 1 0.125 true false false Author 10071844 /api/author/10071844 Krokker Lilla (Orvostudomány) Krokker Lilla true true Krokker L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96371598 /api/authorship/96371598 Szabó, B.* [Szabó, Borbála (Endokrinológia), szerző] Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT) 2 0.125 true false false Author 10065387 /api/author/10065387 Szabó Borbála (Endokrinológia) Szabó Borbála true true Szabó B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96371599 /api/authorship/96371599 Németh, K. [Németh, Kinga (orvostudományok), szerző] MTA-SE Lendület Örökletes Endokrin Daganatok Ku... (SE / AOK / K / IISZBK) 3 0.125 false false false Author 10052152 /api/author/10052152 Németh Kinga (orvostudományok) Németh Kinga true 10052152 true Németh K. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96371600 /api/authorship/96371600 Tóháti, R. 4 0.125 false false false Tóháti R. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96371601 /api/authorship/96371601 Sarkadi, B. [Sarkadi, Balázs (klinikai orvostud...), szerző] MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT) 5 0.125 false false false Author 10057384 /api/author/10057384 Sarkadi Balázs (klinikai orvostudományok) Sarkadi Balázs true 10057384 true Sarkadi B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96371602 /api/authorship/96371602 Mészáros, K. [Mészáros, Katalin (orvosi laboratóri...), szerző] MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT) 6 0.125 false false false Author 10058121 /api/author/10058121 Mészáros Katalin (orvosi laboratóriumi diagnosztika) Mészáros Katalin true 10058121 true Mészáros K. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96371603 /api/authorship/96371603 Patócs, A. [Patócs, Attila Balázs (Orvostudomány), szerző] Országos Onkológiai Intézet; Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT) 7 0.125 false false false Author 10001006 /api/author/10001006 Patócs Attila Balázs (Orvostudomány) Patócs Attila Balázs true 10001006 true Patócs A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96371604 /api/authorship/96371604 Butz, H. ✉ [Butz, Henriett (orvostudomány), szerző] Országos Onkológiai Intézet; Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT) 8 0.125 false true true Author 10020420 /api/author/10020420 Butz Henriett (orvostudomány) Butz Henriett true 10020420 true Butz H. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18822335 /api/publicationidentifier/18822335 DOI: 10.3389/pore.2021.640676 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3389/pore.2021.640676 https://doi.org/10.3389/pore.2021.640676 false true PublicationIdentifier 18848051 /api/publicationidentifier/18848051 WoS: 000646936700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000646936700001 https://www.webofscience.com/wos/woscc/full-record/000646936700001 false true PublicationIdentifier 18822334 /api/publicationidentifier/18822334 Scopus: 85105275232 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85105275232 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105275232 false true PublicationIdentifier 20432573 /api/publicationidentifier/20432573 PubMed: 34257605 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34257605 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34257605&dopt=Abstract false true Keyword 1052850 /api/keyword/1052850 adrenal tumor true 1052850 true Keyword 1056340 /api/keyword/1056340 pheochromocytoma true 1056340 true Keyword 1156149 /api/keyword/1156149 pituitary adenoma true 1156149 true Keyword 1493558 /api/keyword/1493558 ADRENOCORTICAL CARCINOMA true true Keyword 1542054 /api/keyword/1542054 3D cell culture true true Keyword 1745978 /api/keyword/1745978 PitNet true true SjrRating 11225850 /api/sjrrating/11225850 sjr:Q2 (2021) Scopus - Medicine (miscellaneous) PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 968 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q2 DIRECT true true Reference 20722493 /api/reference/20722493 1. 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(2021) PATHOLOGY AND ONCOLOGY RESEARCH 1219-4956 1532-2807 27<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071844"><a href="/gui2/?type=authors&mode=browse&sel=10071844" target="_blank">Krokker L. (<span class="authorship-author-name">Krokker Lilla</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="II. Sz. Belgyógyászati Klinika">IISZBK</span>/MTA-SE Lendület Örökletes Endokrin Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065387"><a href="/gui2/?type=authors&mode=browse&sel=10065387" target="_blank">Szabó B.^* (<span class="authorship-author-name">Szabó Borbála</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052152"><a href="/gui2/?type=authors&mode=browse&sel=10052152" target="_blank">Németh K. (<span class="authorship-author-name">Németh Kinga</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="II. Sz. Belgyógyászati Klinika">IISZBK</span>/MTA-SE Lendület Örökletes Endokrin Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tóháti R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057384"><a href="/gui2/?type=authors&mode=browse&sel=10057384" target="_blank">Sarkadi B. (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> klinikai orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058121"><a href="/gui2/?type=authors&mode=browse&sel=10058121" target="_blank">Mészáros K. (<span class="authorship-author-name">Mészáros Katalin</span> <span class="authorAux-mtmt"> orvosi laboratóriumi diagnosztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001006"><a href="/gui2/?type=authors&mode=browse&sel=10001006" target="_blank">Patócs A. (<span class="authorship-author-name">Patócs Attila Balázs</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020420"><a href="/gui2/?type=authors&mode=browse&sel=10020420" target="_blank">Butz H. ✉ (<span class="authorship-author-name">Butz Henriett</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32029268" target="_blank">Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">27</span> <span class="page"> Paper 640676. 10 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/pore.2021.640676" target="_blank" href="https://doi.org/10.3389/pore.2021.640676"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000646936700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000646936700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85105275232" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85105275232"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34257605" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34257605&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 11 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;13 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32029268&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32029268</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (STIA-KF-19), (NKFI FK 135065) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (ÚNKP-19-4- SE-15), (Janos Bolyai Research Fellowship) Támogató: MTA Bolyai pályázat, (K125231) Támogató: NKFIH, (Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2022.10.11. 11:17 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.11. 09:19 Wolf György (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary Hereditary Tumours Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary Cited By :8 Export Date: 13 Dec...</pre> </div></div>