https://m2.mtmt.hu/ hun 2026-10-24 04:56 JournalArticle 32012870 VALIDATED true Universitätsklinikum Heidelberg, Department of Cardiac Surgery, Heidelberg, Germany Universitätsklinikum Halle und Medizinische Fakultät, Department of Cardiac Surgery, Halle, Germany Semmelweis Egyetem, Heart and Vascular Center, Budapest, Hungary Universitätsklinikum Heidelberg, Department of Medicine I and Clinical Chemistry, Heidelberg, Germany Export Date: 07 November 2025; Cited By: 0; Correspondence Address: S. Korkmaz-Icöz; Laboratory of Cardiac Surgery, Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, 69120, Germany; email: korkmaz@uni-heidelberg.de 0 false 2026-10-21T08:32:10.450+0000 2025-11-07T12:52:34.156+0000 2021-05-13T09:09:26.398+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin true 2025-11-07T12:52:34.014+0000 2023-05-11T08:41:57.676+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Korkmaz-Icoez, Sevil Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation-gene expression profiling true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 43 4 1995 2013 1995 19 2021 The use of hearts with left-ventricular (LV) hypertrophy (LVH) could offer an opportunity to extend the donor pool for cardiac transplantation. We assessed the effects of LVH in 18-month-old spontaneously hypertensive stroke-prone (SHRSP) donor rats and following transplantation. In donors, cardiac function and structural alterations were assessed. Then, the hearts were transplanted into young normotensive-rats. We evaluated LV graft function 1 h after transplantation. The myocardial expression of 92 genes involved in apoptosis, inflammation, and oxidative-stress was profiled using PCR-array. Compared to controls, SHRSP-rats developed LVH, had increased LV systolic performance (slope of the end-diastolic pressure-volume (PV) relationship: 1.6 +/- 0.2 vs 0.8 +/- 0.1mmHg/mu l, p<0.05) accompanied by diastolic dysfunction [prolonged time constant of LV pressure decay (Tau: 15.8 +/- 0.6 vs 12.3 +/- 0.5ms) and augmented diastolic stiffness (LV end-diastolic PV relationship: 0.103 +/- 0.012 vs 0.045 +/- 0.006mmHg/ml), p<0.05]. They presented ECG changes, myocardial fibrosis, and increased nitrotyrosine immunoreactivity and plasma troponin-T and creatine kinase-CM levels. After transplantation, even though the graft contractility was better in SHRSP rats compared to controls, the adverse impact of ischemia/reperfusion-injury on contractility was not altered (E-es ratio after versus before transplantation: 32% vs 29%, p>0.05). Whereas nitrotyrosine immunoreactivity was higher, myeloperoxidase-positive cell infiltration was decreased in the SHRSP+transplanted compared to control+transplanted. Among the tested genes, LVH was associated with altered expression of 38 genes in donors, while transplantation of these hearts resulted in the change of four genes. Alterations in 18-month-old donor hearts, as a consequence of hypertension and LVH, were not associated with graft dysfunction in the early phase of reperfusion after transplantation. Funding 2009413 /api/funding/2009413 false true Funding 2009414 /api/funding/2009414 false true Funding 2009415 /api/funding/2009415 false true true 2021 true true true false true false NONE 2026-10-21 false 1 0 1 1 0 1 1 1 0 1 1 1 1 1 0 0 1 1 1 1 0 6 6 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 D1 false false false false 2021-08-11T09:32:50.173+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K) 3 10 1 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 96277331 /api/authorship/96277331 1 0.083 true false true Korkmaz-Icoez Sevil true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277332 /api/authorship/96277332 2 0.083333336 false false false Akca Deniz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277333 /api/authorship/96277333 3 0.083333336 false false false Li Shiliang true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277334 /api/authorship/96277334 4 0.083333336 false false false Loganathan Sivakkanan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277335 /api/authorship/96277335 5 0.083333336 false false false Brlecic Paige true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277336 /api/authorship/96277336 6 0.083 false false false Author 10060212 /api/author/10060212 Ruppert Mihály true 10060212 true Ruppert Mihaly true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277337 /api/authorship/96277337 7 0.083 false false false Author 10069723 /api/author/10069723 Sayour Alex Ali true true Sayour Alex Ali true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277338 /api/authorship/96277338 8 0.083333336 false false false Simm Andreas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277339 /api/authorship/96277339 9 0.083333336 false false false Brune Maik true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277340 /api/authorship/96277340 10 0.083 false false false Author 10013969 /api/author/10013969 Radovits Tamás true 10013969 true Radovits Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277341 /api/authorship/96277341 11 0.083333336 false false false Karck Matthias true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 96277342 /api/authorship/96277342 12 0.083333336 false true false Szabo Gabor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18776082 /api/publicationidentifier/18776082 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s11357-021-00348-8 https://doi.org/10.1007/s11357-021-00348-8 false true PublicationIdentifier 18776083 /api/publicationidentifier/18776083 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000641198700001 https://www.webofscience.com/wos/woscc/full-record/000641198700001 false true PublicationIdentifier 20147109 /api/publicationidentifier/20147109 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85116359198 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85116359198 false true PublicationIdentifier 18776084 /api/publicationidentifier/18776084 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33871784 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33871784&dopt=Abstract false true Keyword 1011596 /api/keyword/1011596 true 1011596 true Keyword 1039609 /api/keyword/1039609 true 1039609 true Keyword 1094630 /api/keyword/1094630 true 1094630 true Keyword 2307838 /api/keyword/2307838 true true SjrRating 11253606 /api/sjrrating/11253606 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 DIRECT true true Reference 20443383 /api/reference/20443383 1 false true Reference 20443382 /api/reference/20443382 2 false true Reference 20443381 /api/reference/20443381 3 false true Reference 20443380 /api/reference/20443380 4 false true Reference 20443379 /api/reference/20443379 5 false true Reference 20443378 /api/reference/20443378 6 false true Reference 20443377 /api/reference/20443377 7 false true Reference 20443376 /api/reference/20443376 8 false true Reference 20443375 /api/reference/20443375 9 false true Reference 20443374 /api/reference/20443374 10 false true Reference 20443373 /api/reference/20443373 11 false true Reference 20443372 /api/reference/20443372 12 false true Reference 20443371 /api/reference/20443371 13 false true Reference 20443370 /api/reference/20443370 14 false true Reference 20443369 /api/reference/20443369 15 false true Reference 20443368 /api/reference/20443368 16 false true Reference 20443367 /api/reference/20443367 17 false true Reference 20443366 /api/reference/20443366 18 false true Reference 20443365 /api/reference/20443365 19 false true Reference 20443364 /api/reference/20443364 20 false true Reference 20443363 /api/reference/20443363 21 false true Reference 20443362 /api/reference/20443362 22 false true Reference 20443361 /api/reference/20443361 23 false true Reference 20443360 /api/reference/20443360 24 false true Reference 20443359 /api/reference/20443359 25 false true Reference 20443358 /api/reference/20443358 26 false true Reference 20443357 /api/reference/20443357 27 false true Reference 20443356 /api/reference/20443356 28 false true Reference 20443355 /api/reference/20443355 29 false true Reference 20443354 /api/reference/20443354 30 false true Reference 20443353 /api/reference/20443353 31 false true Reference 20443352 /api/reference/20443352 32 false true Reference 20443351 /api/reference/20443351 33 false true /api/publication/32012870 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Korkmaz-Icoez Sevil ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Akca Deniz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Li Shiliang </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Loganathan Sivakkanan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brlecic Paige </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060212"><a href="/gui2/?type=authors&mode=browse&sel=10060212" target="_blank">Ruppert Mihaly (<span class="authorship-author-name">Ruppert Mihály</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069723"><a href="/gui2/?type=authors&mode=browse&sel=10069723" target="_blank">Sayour Alex Ali (<span class="authorship-author-name">Sayour Alex Ali</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Simm Andreas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brune Maik </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Radovits Tamas (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Karck Matthias </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabo Gabor </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32012870" target="_blank">Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation-gene expression profiling</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">43</span> <span class="journal-issue">4</span> <span class="page"> pp 1995-2013 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-021-00348-8" target="_blank" href="https://doi.org/10.1007/s11357-021-00348-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000641198700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000641198700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85116359198" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85116359198"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33871784" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33871784&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32012870&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32012870</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH, (Higher Education Institutional Excellence Program of the Ministry for Innovation and Technology in Hungary, within the Semmelweis University), (Therapeutic Development Thematic Programme of the Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2025.11.07. 13:52 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Universitätsklinikum Heidelberg, Department of Cardiac Surgery, Heidelberg, Germany Universitätsklinikum Halle und Medizinische Fakultät, Department of Cardiac Surgery, Halle, Germany Semmelweis Egyetem, Heart and Vascular Center, Budapest, Hungary Universitätsklinikum Heidelberg, Department of Medicine I and Clinical Chemi...</pre> </div></div>