Brain-wide mapping of presynaptic inputs to basolateral amygdala neurons

Morikawa, S.; Katori, K.; Takeuchi, H.; Ikegaya, Y.

Angol nyelvű Szakcikk (Folyóiratcikk) Tudományos
Megjelent: JOURNAL OF COMPARATIVE NEUROLOGY 0021-9967 1096-9861 529 (11) pp. 3062-3075 2021
  • SJR Scopus - Neuroscience (miscellaneous): Q1
The basolateral amygdala (BLA), a region critical for emotional processing, is the limbic hub that is connected with various brain regions. BLA neurons are classified into different subtypes that exhibit differential projection patterns and mediate distinct emotional behaviors; however, little is known about their presynaptic input patterns. In this study, we employed projection-specific monosynaptic rabies virus tracing to identify the direct monosynaptic inputs to BLA subtypes. We found that each neuronal subtype receives long-range projection input from specific brain regions. In contrast to their specific axonal projection patterns, all BLA neuronal subtypes exhibited relatively similar input patterns. This anatomical organization supports the idea that the BLA is a central integrator that associates sensory information in different modalities with valence and sends associative information to behaviorally relevant brain regions. © 2021 Wiley Periodicals LLC.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2024-05-28 15:55