https://m2.mtmt.hu/ hun 2026-05-01 15:36 JournalArticle 32009587 ADMIN_APPROVED true 0 false 2026-04-30T13:41:53.445+0000 2024-07-04T08:55:58.129+0000 2021-05-11T13:47:57.857+0000 true 10001424 Tompa Péter /api/author/10001424 Author Tompa Péter (Enzimológia) true 10001424 2026-02-24T09:00:07.187+0000 2026-02-24T09:00:07.187+0000 2024-07-04T08:55:58.428+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin Pécsi Éva (MTMT Közp 2,3, admin) true Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2022-12-13T07:02:00.934+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType Sokszerzős vagy csoportos szerzőségű szakcikk (Folyóiratcikk) 104 true 10000359 true 1 /api/category/1 Category Tudományos true 1 Necci, M. true true /api/journal/10001306 REVIEWED NATURE METHODS 1548-7091 1548-7105 true false 10001306 false 10001306 true 1548-7091 1548-7105 Journal FOREIGN 18 5 472 481 472 10 2021 Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high. The Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment was established as a community-based blind test to determine the state of the art in prediction of intrinsically disordered regions and the subset of residues involved in binding. A total of 43 methods were evaluated on a dataset of 646 proteins from DisProt. The best methods use deep learning techniques and notably outperform physicochemical methods. The top disorder predictor has Fmax = 0.483 on the full dataset and Fmax = 0.792 following filtering out of bona fide structured regions. Disordered binding regions remain hard to predict, with Fmax = 0.231. Interestingly, computing times among methods can vary by up to four orders of magnitude. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc. 2021 true true true false true false GOLD 2026-04-30 true https://doi.org/10.1038/s41592-021-01117-3 270 0 270 176 9 269 269 248 258 270 270 176 176 176 94 0 270 176 270 176 0 8 8 Folyóiratcikk Journal Article 24 261 Könyvrészlet Chapter in Book 25 9 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 21 11 21 11 2022 0 53 32 53 32 2023 0 69 44 69 44 2024 0 50 39 50 39 2025 0 60 41 60 41 2026 0 17 9 17 9 D1 false 10018751,10080161,10060353,10062740,10000611,10011280 false false false 2021-08-09T13:50:41.900+0000 Biokémiai Tanszék (ELTE / TTK / Bio_I); Enzimológiai Intézet (TTK); MTA-ELTE Lendület Bioinformatika Kutatócsoport (ELTE / TTK / Bio_I / Biokem_Tsz) 11 15 3 98 0 true 10014568 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 96263299 /api/authorship/96263299 Necci, M. 1 0.0 true false false Necci M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263300 /api/authorship/96263300 Piovesan, D. 2 0.0 false false false Piovesan D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263301 /api/authorship/96263301 Hoque, M.T. 3 0.0 false false false Hoque M.T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263302 /api/authorship/96263302 Walsh, I. 4 0.0 false false false Walsh I. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263303 /api/authorship/96263303 Iqbal, S. 5 0.0 false false false Iqbal S. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263304 /api/authorship/96263304 Vendruscolo, M. 6 0.0 false false false Vendruscolo M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263305 /api/authorship/96263305 Sormanni, P. 7 0.0 false false false Sormanni P. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263306 /api/authorship/96263306 Wang, C. 8 0.0 false false false Wang C. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263307 /api/authorship/96263307 Raimondi, D. 9 0.0 false false false Raimondi D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263308 /api/authorship/96263308 Sharma, R. 10 0.0 false false false Sharma R. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263309 /api/authorship/96263309 Zhou, Y. 11 0.0 false false false Zhou Y. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263310 /api/authorship/96263310 Litfin, T. 12 0.0 false false false Litfin T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263311 /api/authorship/96263311 Galzitskaya, O.V. 13 0.0 false false false Galzitskaya O.V. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263312 /api/authorship/96263312 Lobanov, M.Y. 14 0.0 false false false Lobanov M.Y. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263313 /api/authorship/96263313 Vranken, W. 15 0.0 false false false Vranken W. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263314 /api/authorship/96263314 Wallner, B. 16 0.0 false false false Wallner B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263315 /api/authorship/96263315 Mirabello, C. 17 0.0 false false false Mirabello C. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263316 /api/authorship/96263316 Malhis, N. 18 0.0 false false false Malhis N. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 96263317 /api/authorship/96263317 Dosztányi, Z. 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(2021) NATURE METHODS 1548-7091 1548-7105 18 5 472-481<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Necci M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000611"><a href="/gui2/?type=authors&mode=browse&sel=10000611" target="_blank">Dosztányi Z. (<span class="authorship-author-name">Dosztányi Zsuzsanna</span> <span class="authorAux-mtmt"> Fehérje szerkezetek elméleti vizsgálata</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062740"><a href="/gui2/?type=authors&mode=browse&sel=10062740" target="_blank">Erdős G. (<span class="authorship-author-name">Erdős Gábor</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/<span title="Biokémiai Tanszék">Biokem_Tsz</span>/MTA-ELTE Lendület Bioinformatika Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080161"><a href="/gui2/?type=authors&mode=browse&sel=10080161" target="_blank">Hatos A. (<span class="authorship-author-name">Hatos András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019487"><a href="/gui2/?type=authors&mode=browse&sel=10019487" target="_blank">Horvath T. (<span class="authorship-author-name">Horváth Tamás</span> <span class="authorAux-mtmt"> Enzimológia, Tompa csop</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060353"><a href="/gui2/?type=authors&mode=browse&sel=10060353" target="_blank">Murvai N. (<span class="authorship-author-name">Murvai Nikoletta</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058394"><a href="/gui2/?type=authors&mode=browse&sel=10058394" target="_blank">Pancsa R. (<span class="authorship-author-name">Pancsa Rita</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018758"><a href="/gui2/?type=authors&mode=browse&sel=10018758" target="_blank">Schad E. (<span class="authorship-author-name">Schád Éva</span> <span class="authorAux-mtmt"> Szerkezeti biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018751"><a href="/gui2/?type=authors&mode=browse&sel=10018751" target="_blank">Szabo B. (<span class="authorship-author-name">Szabó Beáta</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011280"><a href="/gui2/?type=authors&mode=browse&sel=10011280" target="_blank">Tantos A. (<span class="authorship-author-name">Tantos Ágnes</span> <span class="authorAux-mtmt"> Molekuláris Biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044721"><a href="/gui2/?type=authors&mode=browse&sel=10044721" target="_blank">Szaniszló T. (<span class="authorship-author-name">Szaniszló Tamás</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001424"><a href="/gui2/?type=authors&mode=browse&sel=10001424" target="_blank">Tompa P. (<span class="authorship-author-name">Tompa Péter</span> <span class="authorAux-mtmt"> Enzimológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; et al. (98) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">CAID Predictors</span> ;&nbsp;&nbsp;&nbsp; <span class="author-affil">DisProt Curators</span> </div> <div><a target="_blank" href="/api/publication/32009587?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32009587" target="_blank">Critical assessment of protein intrinsic disorder prediction</a></div> <div> <span class="journal-title">NATURE METHODS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1548-7091">1548-7091</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1548-7105">1548-7105</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">5</span> <span class="page"> pp 472-481 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41592-021-01117-3" target="_blank" href="https://doi.org/10.1038/s41592-021-01117-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000641237500004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000641237500004"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="111243" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/111243"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85104988931" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85104988931"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33875885" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33875885&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biotechnology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 270</span> | Független: 176 | Függő: 94 | Nem jelölt: 0 | WoS jelölt: 248 | Scopus jelölt:&nbsp;258 | WoS/Scopus jelölt:&nbsp;270 | DOI jelölt:&nbsp;269 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32009587&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32009587</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2024.07.04. 10:55 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2022.12.13. 08:02 Vándor Andrea (VA, admin) </div> </div></div>