We hypothesized that local/regional properties of stimulated structure/circuitry contribute
to the effect of deep brain stimulation (DBS). We analyzed intracerebral electroencephalographic
(EEG) recordings from externalized DBS electrodes targeted bilaterally in the anterior
nuclei of the thalamus (ANT) in 12 patients (six responders, six nonresponders) with
more than 1 year of follow-up care. In the bipolar local field potentials of the EEG,
spectral power (PW) and power spectral entropy (PSE) were calculated in the passbands
1-4, 4-8, 8-12, 12-20, 20-45, 65-80, 80-200 and 200-500 Hz. The most significant differences
between responders and nonresponders were observed in the BRIDGE area (bipolar recordings
with one contact within the ANT and the second contact in adjacent tissue). In responders,
PW was significantly decreased in the frequency bands of 65-80, 80-200, and 200-500
Hz (p < .05); PSE was significantly increased in all frequency bands (p < .05) except
for 200-500 Hz (p = .06). The local EEG characteristics of ANT recorded after implantation
may play a significant role in DBS response prediction.
