https://m2.mtmt.hu/ hun 2026-09-22 06:53 JournalArticle 31997781 VALIDATED true 0 false 2026-05-20T19:20:21.332+0000 2026-02-17T12:57:26.132+0000 2021-05-04T09:11:04.095+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-02-17T12:57:26.141+0000 2026-02-17T12:57:26.141+0000 2022-06-25T12:08:30.124+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2026-01-26T16:13:41.604+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tidrenczel, Zsolt Trends in the prenatal diagnosis of trisomy 21 show younger maternal age and shift in the distribution of congenital heart disease over a 20-year period true true /api/journal/10001111 REVIEWED true false 10001111 false 10001111 true 1552-4825 1552-4833 Journal FOREIGN 185 6 1732 1742 1732 11 2021 Prenatal testing has changed greatly over the past two decades, which may affect the diagnosis of congenital heart disease (CHD) in Down syndrome. The present study aimed to analyze changes in the prevalence and distribution of CHD diagnosed via ultrasonography and fetopathology in 462 fetuses with trisomy 21 between two consecutive 10-year periods (1999-2018), as well as the associations between CHDs, ultrasound markers, and extracardiac malformations. Overall, the frequency of cardiovascular malformations in trisomy 21 was 27.7 and 26.5%, and ultrasound identified 70 and 62% of CHDs during these periods. A profound increase in first-trimester ultrasound findings and associated anomalies with CHDs (ventricular septal defect, Tetralogy of Fallot) since 2009 were observed. Second-trimester nonstructural heart abnormalities were associated with ultrasound anomalies (74%) and major extracardiac malformations (42.9%). During both study periods, mothers carrying fetuses with CHD were significantly younger than those without CHD (p = 0.038, p = 0.009, respectively). Comparing the two 10-year periods, there were no changes in the prevalence and detection of CHDs. Trend analysis revealed that, although the frequency of CHD remained stable, the diagnostic spectrum had shifted between the study periods. Detection of nonstructural heart abnormalities necessitates detailed follow-up for cardiac/extracardiac malformations and chromosomal disorders. true true 2021 true true true false true false PAY 2026-05-20 false 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 0 0 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 Q2 false false false false 2021-08-02T09:31:16.306+0000 Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika Üllői úti r... 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false true Reference 20229746 /api/reference/20229746 41 false true Reference 20229745 /api/reference/20229745 42 false true Reference 20229744 /api/reference/20229744 43 false true /api/publication/31997781 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10048374"><a href="/gui2/?type=authors&mode=browse&sel=10048374" target="_blank">Tidrenczel Zsolt ✉ (<span class="authorship-author-name">Tidrenczel Zsolt</span> <span class="authorAux-mtmt"> Szülészet- nőgyógyászat, Genetika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hajdu Julia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061557"><a href="/gui2/?type=authors&mode=browse&sel=10061557" target="_blank">Simonyi Atene (<span class="authorship-author-name">Simonyi Aténé Szandra</span> <span class="authorAux-mtmt"> Biológus, Doktorandusz</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022275"><a href="/gui2/?type=authors&mode=browse&sel=10022275" target="_blank">Szabo Istvan (<span class="authorship-author-name">Szabó István</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Acs Nandor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Demeter Janos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000568"><a href="/gui2/?type=authors&mode=browse&sel=10000568" target="_blank">Beke Artur (<span class="authorship-author-name">Beke Artúr</span> <span class="authorAux-mtmt"> Genetika, Szülészeti genetika, Szülészet-Nőgyóg...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31997781" target="_blank">Trends in the prenatal diagnosis of trisomy 21 show younger maternal age and shift in the distribution of congenital heart disease over a 20-year period</a></div> <div> <span class="journal-title">AMERICAN JOURNAL OF MEDICAL GENETICS PART A</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1552-4825">1552-4825</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1552-4833">1552-4833</a>)</span>: <span class="journal-volume">185</span> <span class="journal-issue">6</span> <span class="page"> pp 1732-1742 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1002/ajmg.a.62162" target="_blank" href="https://doi.org/10.1002/ajmg.a.62162"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000626091800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000626091800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85102195327" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85102195327"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33683014" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33683014&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31997781</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.02.17. 13:57 Balázs András (MTMT Központ, admin) </div> <div class="lockedBy">Központi kezelésű 2026.01.26. 17:13 Kovács Marcell (MTMT Közp., admin) </div> </div></div>