Endokrinológia és anyagcserebetegségek (benne cukorbetegség, hormonok)
Farmakológia és gyógyszerészet
Dysfunction of the nervous system is well-known in diabetes and also among patients
with prediabetes, obesity and hypertension. However, there is only a limited amount
of data available on the changes in neuronal function in polycystic ovary syndrome
(PCOs), despite the fact that this condition is also accompanied by metabolic and
vascular abnormalities. The aim of our study was to assess the cardiovascular autonomic
and peripheral sensory function in patients with PCOs. The study involved 27 women
with PCOs, and 24 healthy women as control subjects. Autonomic neuropathy (AN) was
assessed using the four standard cardiovascular reflex tests. Peripheral sensory function
was determined using the Neurometer. Electric stimulation was applied transcutaneously
and the current perception threshold (CPT) values were determined on the median and
peroneal nerves. No significant differences were found between the PCOs patients and
the control group regarding the cardiovascular autonomic reflex tests and the AN scores.
The CPT values of PCOs patients in the median and peroneal nerves were lower at all
frequencies in comparison to controls. Conclusions: The cardiovascular autonomic nerve
function was normal in the patients with PCOs. The current perception thresholds were
consequently lower in the PCOs patients both in the upper and lower extremities at
all frequencies, which serves as an early sign of neuropathy. As a novel observation,
our results suggest that early neuronal damage manifests in the form of sensory hyperaesthesia
in patients with PCOs.
