The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications

Liang, Y.-F.; Long, Z.-X.; Zhang, Y.-J.; Luo, C.-Y.; Yan, L.-T.; Gao, W.-Y. ✉; Li, H. ✉

English Scientific Survey paper (Journal Article)
Published: BIOCHIMIE 0300-9084 1638-6183 184 pp. 72-87 2021
  • SJR Scopus - Biochemistry: Q1
l-Valine, l-isoleucine, and l-leucine are three key proteinogenic amino acids, and they are also the essential amino acids required for mammalian growth, possessing important and to some extent, special physiological and biological functions. Because of the branched structures in their carbon chains, they are also named as branched-chain amino acids (BCAAs). This review will highlight the advance in studies of the enzymes involved in the biosynthetic pathway of BCAAs, concentrating on their chemical mechanisms and applications in screening herbicides and antibacterial agents. The uses of some of these enzymes in lab scale organic synthesis are also discussed. © 2021 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)
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2021-12-06 18:02