https://m2.mtmt.hu/ hun 2026-09-20 16:13 JournalArticle 31952529 APPROVED true This study was presented as an oral presentation at the 12th. Vaccine Congress (Elsevier Sciences),in Budapest, Hungary, 16 September 2018. Department of Family Medicine, Semmelweis University Medical School, Budapest, 1125, Hungary Department of Pediatric Dentistry, Semmelweis University Medical School, Budapest, 1088, Hungary Clinical Center, University of Debrecen, Debrecen, 4032, Hungary Export Date: 13 July 2021 Correspondence Address: Vajo, Z.; Department of Family Medicine, Hungary; email: zoltanvajo@gmail.com 0 false 2026-08-22T19:48:19.366+0000 2022-03-09T09:12:05.278+0000 2021-04-06T12:39:43.750+0000 true 10018804 Szalóky-Siki Ágnes /api/admin/10018804 Admin true 10018804 2026-08-22T19:47:14.929+0000 2021-04-09T11:46:03.966+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Vajo, Zoltan A Reduced Dose Whole Virion Aluminum Adjuvanted Seasonal Influenza Vaccine Is Immunogenic, Safe, and Well Tolerated in Pediatric Patients true true /api/journal/10015873 REVIEWED true false 10015873 false 10015873 true 1999-4915 Journal FOREIGN 13 3 500 500 8 2021 Background: Data suggest that pediatric patients might react differently to influenza vaccination, both in terms of immunity and side effects. We have recently shown that using a whole virion vaccine with aluminum phosphate adjuvants, reduced dose vaccines containing 6 mu g of viral hemagglutinin (HA) per strain are immunogenic, and well tolerated in adult and elderly patients. Here we show the results of a multicenter clinical trial of pediatric patients, using reduced doses of a new, whole virion, aluminum phosphate adjuvanted vaccine (FluArt, Budapest, Hungary). Methods: A total of 120 healthy volunteers were included in two age groups (3-11 years, receiving 3 mu g of HA per strain, and 12-18 years, receiving 6 mu g of HA per strain). We used hemagglutination inhibition testing to assess immunogenicity, based on EMA and FDA licensing criteria, including post/pre-vaccination geometric mean titer ratios, seroconversion and seropositivity rates. Safety and tolerability were assessed using CHMP guidelines. Results: All subjects entered the study and were vaccinated (ITT population). All 120 subjects attended the control visit on Day 21 (PP population). All immunogenicity licensing criteria were met in both age groups for all three vaccine virus strains. No serious adverse events were detected and the vaccine was well tolerated by both age groups. Discussion: Using a whole virion vaccine and aluminum phosphate adjuvants, a reduction in the amount of the viral hemmaglutinin is possible while maintaining immunogenicity, safety and tolerability in pediatric and adolescent patients. true 2021 true true true false false GOLD 2026-08-22 true https://doi.org/10.3390/v13030500 4 0 4 4 2 4 4 4 4 4 4 4 4 4 0 0 4 4 4 4 0 8 8 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 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<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10001100"><a href="/gui2/?type=authors&mode=browse&sel=10001100" target="_blank">Vajo Zoltan ✉ (<span class="authorship-author-name">Vajó Zoltán</span> <span class="authorAux-mtmt"> Belgyógyászat, geriátria, lipidológia, allergol...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Családorvosi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018905"><a href="/gui2/?type=authors&mode=browse&sel=10018905" target="_blank">Balaton Gergely (<span class="authorship-author-name">Balaton Gergely</span> <span class="authorAux-mtmt"> Gyermekfogászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Gyermekfogászati és Fogszabályozási Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059780"><a href="/gui2/?type=authors&mode=browse&sel=10059780" target="_blank">Vajo Peter (<span class="authorship-author-name">Vajó Péter</span> <span class="authorAux-mtmt"> Gazdálkodás és szervezéstudományok</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/Klinikai Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024079"><a href="/gui2/?type=authors&mode=browse&sel=10024079" target="_blank">Torzsa Peter (<span class="authorship-author-name">Torzsa Péter</span> <span class="authorAux-mtmt"> Családorvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Családorvosi Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31952529" target="_blank">A Reduced Dose Whole Virion Aluminum Adjuvanted Seasonal Influenza Vaccine Is Immunogenic, Safe, and Well Tolerated in Pediatric Patients</a></div> <div> <span class="journal-title">VIRUSES</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4915">1999-4915</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">3</span> <span class="page"> Paper 500. 8 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/v13030500" target="_blank" href="https://doi.org/10.3390/v13030500"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000634227300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000634227300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85103862700" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85103862700"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33803680" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33803680&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Infectious Diseases&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Virology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31952529&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31952529</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2022.03.09. 10:12 Pappné Czappán Marianna (DE/TTK admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: This study was presented as an oral presentation at the 12th. Vaccine Congress (Elsevier Sciences),in Budapest, Hungary, 16 September 2018. Department of Family Medicine, Semmelweis University Medical School, Budapest, 1125, Hungary Department of Pediatric Dentistry, Semmelweis University Medical School, Budapest, 1088, Hungary Clinical Center, Un...</pre> </div></div>