https://m2.mtmt.hu/ hun 2026-09-22 02:27 JournalArticle 31951820 VALIDATED true Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology [uNKP-19-3-I-SE-81]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development And Innovation Fund [uNKP-20-4-I-SE-32]; Semmelweis University [STIA-20-KF]; NKFIH [FK-134267]; Biotechnological and Biosciences Research Council, UK Core Strategic Programme Grant [BB/CSP17270/1]; Institute Strategic Programme Grant for Gut Microbes and Health [BB/R012490/1, BBS/E/F/000PR10353, BBS/E/F/000PR10355] Funding text: This work was supported by the uNKP-19-3-I-SE-81, New National Excellence Program of the Ministry for Innovation and Technology, by the uNKP-20-4-I-SE-32 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development And Innovation Fund, by a STIA-20-KF of Semmelweis University. O.K., M.H. and M.M. were supported by NKFIH FK-134267 (National Research, Development and Innovation Office, Hungary). T.K. was supported by the Biotechnological and Biosciences Research Council, UK Core Strategic Programme Grant (BB/CSP17270/1) and Institute Strategic Programme Grant for Gut Microbes and Health (BB/R012490/1 and its constituent projects, BBS/E/F/000PR10353 and BBS/E/F/000PR10355). Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology [uNKP-19-3-I-SE-81]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development And Innovation Fund [uNKP-20-4-I-SE-32]; Semmelweis University [STIA-20-KF]; NKFIHNational Research, Development & Innovation Office (NRDIO) - Hungary [FK-134267]; Biotechnological and Biosciences Research Council, UK Core Strategic Programme Grant [BB/CSP17270/1]; Institute Strategic Programme Grant for Gut Microbes and Health [BB/R012490/1, BBS/E/F/000PR10353, BBS/E/F/000PR10355] Funding text: This work was supported by the uNKP-19-3-I-SE-81, New National Excellence Program of the Ministry for Innovation and Technology, by the uNKP-20-4-I-SE-32 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development And Innovation Fund, by a STIA-20-KF of Semmelweis University. O.K., M.H. and M.M. were supported by NKFIH FK-134267 (National Research, Development and Innovation Office, Hungary). T.K. was supported by the Biotechnological and Biosciences Research Council, UK Core Strategic Programme Grant (BB/CSP17270/1) and Institute Strategic Programme Grant for Gut Microbes and Health (BB/R012490/1 and its constituent projects, BBS/E/F/000PR10353 and BBS/E/F/000PR10355). 0 false 2026-09-14T13:54:42.554+0000 2022-02-01T13:35:00.790+0000 2021-04-06T08:57:17.284+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 2025-10-22T14:46:50.207+0000 2021-04-06T09:04:09.081+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kapuy, O. true true /api/journal/10015558 REVIEWED CELL DEATH AND DISEASE 2041-4889 2041-4889 true false 10015558 false 10015558 true 2041-4889 2041-4889 Journal FOREIGN 12 4 309 309 11 2021 Although autophagy is a type of programmed cell death, it is also essential for cell survival upon tolerable level of various stress events. For the cell to respond adequately to an external and/or internal stimulus induced by cellular stress, autophagy must be controlled in a highly regulated manner. By using systems biology techniques, here we explore the dynamical features of autophagy induction. We propose that the switch-like characteristic of autophagy induction is achieved by a control network, containing essential feedback loops of four components, so-called autophagy inducer, autophagy controller, mTORC1 and autophagy executor, respectively. We show how an autophagy inducer is capable to turn on autophagy in a cellular stress-specific way. The autophagy controller acts as a molecular switch and not only promotes autophagy but also blocks the permanent hyperactivation of the process via downregulating the autophagy inducer. In this theoretical analysis, we explore in detail the properties of all four proposed controlling elements and their connections. Here we also prove that the kinetic features of this control network can be considered accurate in various stress processes (such as starvation, endoplasmic reticulum stress and oxidative stress), even if the exact components may be different. The robust response of the resulting control network is essential during cellular stress. © 2021, The Author(s). Funding 2008450 /api/funding/2008450 (ÚNKP-19-3-I-SE-81) false true Funding 2008451 /api/funding/2008451 (ÚNKP-20-4-I-SE-32) false true Funding 2008452 /api/funding/2008452 (STIA-20-KF) false true Funding 2008453 /api/funding/2008453 (FK-134267) false true true 2021 true true true false true false GOLD 2026-09-14 true https://doi.org/10.1038/s41419-021-03599-7 23 0 23 19 4 23 23 23 21 23 23 19 19 19 4 0 23 19 23 19 0 9 9 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 6 4 6 4 2023 0 1 1 1 1 2024 0 7 5 7 5 2025 0 3 3 3 3 2026 0 6 6 6 6 D1 false false false false 2021-04-05T09:04:08.825+0000 Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I) 3 7 1 4 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 95899829 /api/authorship/95899829 Kapuy, O. ✉ [Kapuy, Orsolya (Biokémia), szerző] Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I) 1 0.25 true false true Author 10026330 /api/author/10026330 Kapuy Orsolya (Biokémia) Kapuy Orsolya true 10026330 true Kapuy O. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95899830 /api/authorship/95899830 Holczer, M. [Holczer, Marianna (Biokémia), szerző] Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I) 2 0.25 false false false Author 10057448 /api/author/10057448 Holczer Marianna (Biokémia) Holczer Marianna true 10057448 true Holczer M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95899831 /api/authorship/95899831 Márton, M. [Márton, Margita (Biokémia), szerző] Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I) 3 0.25 false false false Author 10057447 /api/author/10057447 Márton Margita (Biokémia) Márton Margita true 10057447 true Márton M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95899832 /api/authorship/95899832 Korcsmáros, T. 4 0.25 false true false Korcsmáros T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18619211 /api/publicationidentifier/18619211 DOI: 10.1038/s41419-021-03599-7 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41419-021-03599-7 https://doi.org/10.1038/s41419-021-03599-7 false true PublicationIdentifier 18619212 /api/publicationidentifier/18619212 WoS: 000632883600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000632883600001 https://www.webofscience.com/wos/woscc/full-record/000632883600001 false true PublicationIdentifier 18619210 /api/publicationidentifier/18619210 Scopus: 85103157094 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85103157094 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85103157094 false true PublicationIdentifier 18619266 /api/publicationidentifier/18619266 PubMed: 33758166 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33758166 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33758166&dopt=Abstract false true SjrRating 11224960 /api/sjrrating/11224960 sjr:D1 (2021) Scopus - Medicine (miscellaneous) CELL DEATH AND DISEASE 2041-4889 132 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true D1 DIRECT true true Reference 19562545 /api/reference/19562545 1. Wang, J., Fan, S.M., Zhang, J., Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute lung injury by suppression of TLR4/NF-kappaB signaling activation (2019) Braz. J. Med. Biol. Res., 52. , PID: 31241712, COI: 1:CAS:528:DC%2BB3cXhtFalt77I 1 false true Reference 19562544 /api/reference/19562544 2. Ito, S., Tanaka, Y., Oshino, R., Okado, S., Hori, M., Isobe, K.I., GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation (2016) Cell Death Dis., 7. , COI: 1:CAS:528:DC%2BC28XotVyrur4%3D, PID: 27171261 2 false true Reference 19562543 /api/reference/19562543 3. Turei, D., NRF2-ome: an integrated web resource to discover protein interaction and regulatory networks of NRF2 (2013) Oxid. Med. Cell Longev., 2013, p. 737591. , PID: 23710289, COI: 1:CAS:528:DC%2BC3sXmvFartb0%3D 3 false true Reference 19562542 /api/reference/19562542 4. Blom, N., Sicheritz-Ponten, T., Gupta, R., Gammeltoft, S., Brunak, S., Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence (2004) Proteomics, 4, pp. 1633-1649. , COI: 1:CAS:528:DC%2BD2cXkvFGitLg%3D, PID: 15174133 4 false true Reference 19562541 /api/reference/19562541 5. Wang, C., GPS 5.0: an update on the prediction of kinase-specific phosphorylation sites in proteins (2020) Genomics Proteomics Bioinformatics, 18, pp. 72-80 5 false true Reference 19562540 /api/reference/19562540 6. Chan, E.Y., Kir, S., Tooze, S.A., siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy (2007) J. Biol. Chem., 282, pp. 25464-25474. , COI: 1:CAS:528:DC%2BD2sXpsFWlsbk%3D, PID: 17595159 6 false true Reference 19562539 /api/reference/19562539 7. B’Chir, W., Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation (2014) Cell Signal, 26, pp. 1385-1391. , PID: 24657471, COI: 1:CAS:528:DC%2BC2cXosFaltLs%3D 7 false true Reference 19562538 /api/reference/19562538 8. Gonzalez, Y., Aryal, B., Chehab, L., Rao, V.A., Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress (2014) Oncotarget, 5, pp. 1526-1537. , PID: 24681637 8 false true Reference 19562537 /api/reference/19562537 9. Zinszner, H., CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum (1998) Genes Dev., 12, pp. 982-995. , COI: 1:CAS:528:DyaK1cXisl2gsr4%3D, PID: 9531536 9 false true Reference 19562536 /api/reference/19562536 10. Adler, H.T., Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins (1999) Mol. Cell Biol., 19, pp. 7050-7060. , COI: 1:CAS:528:DyaK1MXmtlalsL0%3D, PID: 10490642 10 false true Reference 19562535 /api/reference/19562535 11. Harding, H.P., Zhang, Y., Bertolotti, A., Zeng, H., Ron, D., Perk is essential for translational regulation and cell survival during the unfolded protein response (2000) Mol. Cell, 5, pp. 897-904. , COI: 1:CAS:528:DC%2BD3cXjsl2ku7c%3D, PID: 10882126 11 false true Reference 19562534 /api/reference/19562534 12. B’Chir, W., The eIF2alpha/ATF4 pathway is essential for stress-induced autophagy gene expression (2013) Nucleic Acids Res., 41, pp. 7683-7699. , PID: 23804767, COI: 1:CAS:528:DC%2BC3sXhvVeitbjF 12 false true Reference 19562533 /api/reference/19562533 13. McCullough, K.D., Martindale, J.L., Klotz, L.O., Aw, T.Y., Holbrook, N.J., Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state (2001) Mol. Cell Biol., 21, pp. 1249-1259. , COI: 1:CAS:528:DC%2BD3MXovVCntA%3D%3D, PID: 11158311 13 false true Reference 19562532 /api/reference/19562532 14. Holczer, M., Banhegyi, G., Kapuy, O., GADD34 keeps the mTOR pathway inactivated in endoplasmic reticulum stress related autophagy (2016) PLoS ONE, 11. , PID: 27992581, COI: 1:CAS:528:DC%2BC2sXksVKitb8%3D 14 false true Reference 19562531 /api/reference/19562531 15. Harding, H.P., Regulated translation initiation controls stress-induced gene expression in mammalian cells (2000) Mol. Cell, 6, pp. 1099-1108. , COI: 1:CAS:528:DC%2BD3cXosV2mtrs%3D, PID: 11106749 15 false true Reference 19562530 /api/reference/19562530 16. Ma, Y., Hendershot, L.M., Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress (2003) J. Biol. Chem., 278, pp. 34864-34873. , COI: 1:CAS:528:DC%2BD3sXntVWqsb8%3D, PID: 12840028 16 false true Reference 19562529 /api/reference/19562529 17. Holczer, M., Hajdu, B., Lorincz, T., Szarka, A., Banhegyi, G., Kapuy, O., Fine-tuning of AMPK-ULK1-mTORC1 regulatory triangle is crucial for autophagy oscillation (2020) Sci. Rep., 10. , COI: 1:CAS:528:DC%2BB3cXitF2jsbnF, PID: 33082544 17 false true Reference 19562528 /api/reference/19562528 18. Dite, T.A., The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs (2017) Nat. Commun., 8. , PID: 28924239, COI: 1:CAS:528:DC%2BC1cXhtV2ksbvP 18 false true Reference 19562527 /api/reference/19562527 19. Meley, D., AMP-activated protein kinase and the regulation of autophagic proteolysis (2006) J. Biol. Chem., 281, pp. 34870-34879. , COI: 1:CAS:528:DC%2BD28XhtF2gtbjP, PID: 16990266 19 false true Reference 19562526 /api/reference/19562526 20. Inoki, K., Zhu, T., Guan, K.L., TSC2 mediates cellular energy response to control cell growth and survival (2003) Cell, 115, pp. 577-590. , COI: 1:CAS:528:DC%2BD3sXps1OhtL0%3D, PID: 14651849 20 false true Reference 19562525 /api/reference/19562525 21. Gwinn, D.M., AMPK phosphorylation of raptor mediates a metabolic checkpoint (2008) Mol. Cell, 30, pp. 214-226. , COI: 1:CAS:528:DC%2BD1cXlsFentbg%3D, PID: 18439900 21 false true Reference 19562524 /api/reference/19562524 22. Egan, D.F., Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy (2011) Science, 331, pp. 456-461. , COI: 1:CAS:528:DC%2BC3MXpsF2mtg%3D%3D, PID: 21205641 22 false true Reference 19562523 /api/reference/19562523 23. Tyson, J.J., Chen, K.C., Novak, B., Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell (2003) Curr. Opin. Cell Biol., 15, pp. 221-231. , COI: 1:CAS:528:DC%2BD3sXitV2msL8%3D, PID: 12648679 23 false true Reference 19562522 /api/reference/19562522 24. Marton, M., Kurucz, A., Lizak, B., Margittai, E., Banhegyi, G., Kapuy, O., A systems biological view of life-and-death decision with respect to endoplasmic reticulum stress-the role of PERK pathway (2017) Int. J. Mol. Sci., 18, p. 58 24 false true Reference 19562521 /api/reference/19562521 25. Kapuy, O., Marton, M., Banhegyi, G., Vinod, P.K., Multiple system-level feedback loops control life-and-death decisions in endoplasmic reticulum stress (2020) FEBS Lett., 594, pp. 1112-1123. , COI: 1:CAS:528:DC%2BC1MXitlKhur7K, PID: 31769869 25 false true Reference 19562520 /api/reference/19562520 26. Holczer, M., Marton, M., Kurucz, A., Banhegyi, G., Kapuy, O., A comprehensive systems biological study of autophagy-apoptosis crosstalk during endoplasmic reticulum stress (2015) Biomed. Res. Int., 2015, p. 319589. , PID: 25984530, COI: 1:CAS:528:DC%2BC2MXhs1equr7J 26 false true Reference 19562519 /api/reference/19562519 27. Rashid, H.O., Yadav, R.K., Kim, H.R., Chae, H.J., ER stress: autophagy induction, inhibition and selection (2015) Autophagy, 11, pp. 1956-1977. , COI: 1:CAS:528:DC%2BC2MXitVCrt7bF, PID: 26389781 27 false true Reference 19562518 /api/reference/19562518 28. Walter, P., Ron, D., The unfolded protein response: from stress pathway to homeostatic regulation (2011) Science, 334, pp. 1081-1086. , COI: 1:CAS:528:DC%2BC3MXhsV2mu7jL, PID: 22116877 28 false true Reference 19562517 /api/reference/19562517 29. Ogata, M., Autophagy is activated for cell survival after endoplasmic reticulum stress (2006) Mol. Cell Biol., 26, pp. 9220-9231. , COI: 1:CAS:528:DC%2BD28XhtlemsLvI, PID: 17030611 29 false true Reference 19562516 /api/reference/19562516 30. Kosztelnik, M., Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress (2019) FASEB J., 33, pp. 2372-2387. , COI: 1:CAS:528:DC%2BC1MXovFCmsb8%3D, PID: 30277819 30 false true Reference 19562515 /api/reference/19562515 31. Pajares, M., Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes (2016) Autophagy, 12, pp. 1902-1916. , COI: 1:CAS:528:DC%2BC28XhsVWnurrN, PID: 27427974 31 false true Reference 19562514 /api/reference/19562514 32. Stolz, A., Ernst, A., Dikic, I., Cargo recognition and trafficking in selective autophagy (2014) Nat. Cell Biol., 16, pp. 495-501. , COI: 1:CAS:528:DC%2BC2cXovVaktrg%3D, PID: 24875736 32 false true Reference 19562513 /api/reference/19562513 33. Lau, A., A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62 (2010) Mol. Cell Biol., 30, pp. 3275-3285. , COI: 1:CAS:528:DC%2BC3cXptVegu7k%3D, PID: 20421418 33 false true Reference 19562512 /api/reference/19562512 34. Komatsu, M., Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice (2007) Cell, 131, pp. 1149-1163. , COI: 1:CAS:528:DC%2BD1cXksFGnsg%3D%3D, PID: 18083104 34 false true Reference 19562511 /api/reference/19562511 35. Komatsu, M., The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 (2010) Nat. Cell Biol., 12, pp. 213-223. , COI: 1:CAS:528:DC%2BC3cXisFemsL8%3D, PID: 20173742 35 false true Reference 19562510 /api/reference/19562510 36. McMahon, M., Itoh, K., Yamamoto, M., Hayes, J.D., Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression (2003) J. Biol. Chem., 278, pp. 21592-21600. , COI: 1:CAS:528:DC%2BD3sXksVems7g%3D, PID: 12682069 36 false true Reference 19562509 /api/reference/19562509 37. Jain, A., p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription (2010) J. Biol. Chem., 285, pp. 22576-22591. , COI: 1:CAS:528:DC%2BC3cXos1WntLg%3D, PID: 20452972 37 false true Reference 19562508 /api/reference/19562508 38. Stewart, D., Killeen, E., Naquin, R., Alam, S., Alam, J., Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium (2003) J. Biol. Chem., 278, pp. 2396-2402. , COI: 1:CAS:528:DC%2BD3sXksFagtQ%3D%3D, PID: 12441344 38 false true Reference 19562507 /api/reference/19562507 39. Nguyen, T., Nioi, P., Pickett, C.B., The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress (2009) J. Biol. Chem., 284, pp. 13291-13295. , COI: 1:CAS:528:DC%2BD1MXls1Kjtbc%3D, PID: 19182219 39 false true Reference 19562506 /api/reference/19562506 40. Ma, Q., Role of nrf2 in oxidative stress and toxicity (2013) Annu. Rev. Pharm. Toxicol., 53, pp. 401-426. , COI: 1:CAS:528:DC%2BC3sXjt1Wguro%3D 40 false true Reference 19562505 /api/reference/19562505 41. Lee, J.W., Park, S., Takahashi, Y., Wang, H.G., The association of AMPK with ULK1 regulates autophagy (2010) PLoS ONE, 5. , PID: 21072212, COI: 1:CAS:528:DC%2BC3cXhsVentbvL 41 false true Reference 19562504 /api/reference/19562504 42. Dunlop, E.A., Hunt, D.K., Acosta-Jaquez, H.A., Fingar, D.C., Tee, A.R., ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding (2011) Autophagy, 7, pp. 737-747. , COI: 1:CAS:528:DC%2BC38XhtFCisLg%3D, PID: 21460630 42 false true Reference 19562503 /api/reference/19562503 43. Jung, C.H., Seo, M., Otto, N.M., Kim, D.H., ULK1 inhibits the kinase activity of mTORC1 and cell proliferation (2011) Autophagy, 7, pp. 1212-1221. , COI: 1:CAS:528:DC%2BC38XisFSntL4%3D, PID: 21795849 43 false true Reference 19562502 /api/reference/19562502 44. Loffler, A.S., Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop (2011) Autophagy, 7, pp. 696-706. , PID: 21460634, COI: 1:CAS:528:DC%2BC38XhtFCis7Y%3D 44 false true Reference 19562501 /api/reference/19562501 45. Kim, J., Kundu, M., Viollet, B., Guan, K.L.A.M.P.K., and mTOR regulate autophagy through direct phosphorylation of Ulk1 (2011) Nat. Cell Biol., 13, pp. 132-171. , COI: 1:CAS:528:DC%2BC3MXhtlamtb0%3D, PID: 21258367 45 false true Reference 19562500 /api/reference/19562500 46. Ling, N.X.Y., mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress (2020) Nat. Metab., 2, pp. 41-49. , COI: 1:CAS:528:DC%2BB3cXks1Krsrw%3D, PID: 31993556 46 false true Reference 19562499 /api/reference/19562499 47. Holczer, M., Hajdu, B., Lorincz, T., Szarka, A., Banhegyi, G., Kapuy, O., A double negative feedback loop between mTORC1 and AMPK kinases guarantees precise autophagy induction upon cellular stress (2019) Int. J. Mol. Sci., 20, p. 22. , COI: 1:CAS:528:DC%2BB3cXptV2lu70%3D 47 false true Reference 19562498 /api/reference/19562498 48. Alers, S., Loffler, A.S., Wesselborg, S., Stork, B., Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks (2012) Mol. Cell Biol., 32, pp. 2-11. , COI: 1:CAS:528:DC%2BC38Xjt12msro%3D, PID: 22025673 48 false true Reference 19562497 /api/reference/19562497 49. Laplante, M., Sabatini, D.M., mTOR signaling in growth control and disease (2012) Cell, 149, pp. 274-293. , COI: 1:CAS:528:DC%2BC38Xls1eguro%3D, PID: 22500797 49 false true Reference 19562496 /api/reference/19562496 50. Tamargo-Gomez, I., Marino, G., AMPK: regulation of metabolic dynamics in the context of autophagy (2018) Int. J. Mol. Sci., 19, p. 3812. , & 50 false true Reference 19562495 /api/reference/19562495 51. Sarbassov, D.D., Ali, S.M., Sabatini, D.M., Growing roles for the mTOR pathway (2005) Curr. Opin. Cell Biol., 17, pp. 596-603. , COI: 1:CAS:528:DC%2BD2MXhtFyksL7F, PID: 16226444 51 false true Reference 19562494 /api/reference/19562494 52. Hardie, D.G., Ross, F.A., Hawley, S.A., AMPK: a nutrient and energy sensor that maintains energy homeostasis (2012) Nat. Rev. Mol. Cell Biol., 13, pp. 251-262. , COI: 1:CAS:528:DC%2BC38XksVenu7w%3D, PID: 22436748 52 false true Reference 19562493 /api/reference/19562493 53. Bento, C.F., Mammalian autophagy: how does it work? (2016) Annu. Rev. Biochem., 85, pp. 685-713. , COI: 1:CAS:528:DC%2BC28XisVGitL0%3D, PID: 26865532 53 false true Reference 19562492 /api/reference/19562492 54. Russell, R.C., ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase (2013) Nat. Cell Biol., 15, pp. 741-750. , COI: 1:CAS:528:DC%2BC3sXnvVSitb0%3D, PID: 23685627 54 false true Reference 19562491 /api/reference/19562491 55. Hosokawa, N., Sasaki, T., Iemura, S., Natsume, T., Hara, T., Mizushima, N., Atg101, a novel mammalian autophagy protein interacting with Atg13 (2009) Autophagy, 5, pp. 973-979. , COI: 1:CAS:528:DC%2BC3cXmt1ChtQ%3D%3D, PID: 19597335 55 false true Reference 19562490 /api/reference/19562490 56. Jung, C.H., ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery (2009) Mol. Biol. Cell, 20, pp. 1992-2003. , COI: 1:CAS:528:DC%2BD1MXotVyqsL8%3D, PID: 19225151 56 false true Reference 19562489 /api/reference/19562489 57. Hosokawa, N., Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy (2009) Mol. Biol. Cell, 20, pp. 1981-1991. , COI: 1:CAS:528:DC%2BD1MXotVyqsL4%3D, PID: 19211835 57 false true Reference 19562488 /api/reference/19562488 58. Ganley, I.G., Lam du, H., Wang, J., Ding, X., Chen, S., Jiang, X.U.L.K., ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy (2009) J. Biol. Chem., 284, pp. 12297-12305. , COI: 1:CAS:528:DC%2BD1MXltVCmu7c%3D, PID: 19258318 58 false true Reference 19562487 /api/reference/19562487 59. Eskelinen, E.L., Autophagy: supporting cellular and organismal homeostasis by self-eating (2019) Int. J. Biochem. Cell Biol., 111, pp. 1-10. , COI: 1:CAS:528:DC%2BC1MXmvFSntLw%3D, PID: 30940605 59 false true Reference 19562486 /api/reference/19562486 60. Dikic, I., Elazar, Z., Mechanism and medical implications of mammalian autophagy (2018) Nat. Rev. Mol. Cell Biol., 19, pp. 349-364. , COI: 1:CAS:528:DC%2BC1cXosVCns7s%3D, PID: 29618831 60 false true Reference 19562485 /api/reference/19562485 61. Parzych, K.R., Klionsky, D.J., An overview of autophagy: morphology, mechanism, and regulation (2014) Antioxid. Redox Signal, 20, pp. 460-473. , COI: 1:CAS:528:DC%2BC2cXnt1emsw%3D%3D, PID: 23725295 61 false true Reference 19562484 /api/reference/19562484 62. Kroemer, G., Levine, B., Autophagic cell death: the story of a misnomer (2008) Nat. Rev. Mol. Cell Biol., 9, pp. 1004-1010. , COI: 1:CAS:528:DC%2BD1cXhsVWhurjO, PID: 18971948 62 false true Reference 19562483 /api/reference/19562483 63. Green, D.R., Levine, B., To be or not to be? How selective autophagy and cell death govern cell fate (2014) Cell, 157, pp. 65-75. , COI: 1:CAS:528:DC%2BC2cXmtVCgurw%3D, PID: 24679527 63 false true Reference 19562482 /api/reference/19562482 64. Liu, Y., Levine, B., Autosis and autophagic cell death: the dark side of autophagy (2015) Cell Death Differ., 22, pp. 367-376. , COI: 1:CAS:528:DC%2BC2cXhs1ChsbbM, PID: 25257169 64 false true Reference 19562481 /api/reference/19562481 65. Levine, B., Kroemer, G., Autophagy in the pathogenesis of disease (2008) Cell, 132, pp. 27-42. , COI: 1:CAS:528:DC%2BD1cXhtFehtb8%3D, PID: 18191218 65 false true Reference 19562480 /api/reference/19562480 66. Maiuri, M.C., Zalckvar, E., Kimchi, A., Kroemer, G., Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 741-752. , COI: 1:CAS:528:DC%2BD2sXpsVartb8%3D, PID: 17717517 66 false true Reference 19562479 /api/reference/19562479 67. Clarke, P.G., Developmental cell death: morphological diversity and multiple mechanisms (1990) Anat. Embryol. (Berl.), 181, pp. 195-213. , COI: 1:STN:280:DyaK3c3kslKktg%3D%3D 67 false true Reference 19562478 /api/reference/19562478 68. Jin, S., Autophagy, mitochondrial quality control, and oncogenesis (2006) Autophagy, 2, pp. 80-84. , COI: 1:CAS:528:DC%2BD28Xkt1KlsL0%3D, PID: 16874075 68 false true Reference 19562477 /api/reference/19562477 69. Wirawan, E., Vanden Berghe, T., Lippens, S., Agostinis, P., Vandenabeele, P., Autophagy: for better or for worse (2012) Cell Res., 22, pp. 43-61. , COI: 1:CAS:528:DC%2BC38Xks1Chtg%3D%3D, PID: 21912435 69 false true Reference 19562476 /api/reference/19562476 70. Yin, Z., Pascual, C., Klionsky, D.J., Autophagy: machinery and regulation (2016) Micro. Cell, 3, pp. 588-596. , COI: 1:CAS:528:DC%2BC1cXhtlejurs%3D 70 false true /api/publication/31951820 Kapuy O. et al. Autophagy-dependent survival is controlled with a unique regulatory network upon various cellular stress events. (2021) CELL DEATH AND DISEASE 2041-4889 2041-4889 12 4<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10026330"><a href="/gui2/?type=authors&mode=browse&sel=10026330" target="_blank">Kapuy O. ✉ (<span class="authorship-author-name">Kapuy Orsolya</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biokémiai és Molekuláris Biológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057448"><a href="/gui2/?type=authors&mode=browse&sel=10057448" target="_blank">Holczer M. (<span class="authorship-author-name">Holczer Marianna</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biokémiai és Molekuláris Biológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057447"><a href="/gui2/?type=authors&mode=browse&sel=10057447" target="_blank">Márton M. (<span class="authorship-author-name">Márton Margita</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biokémiai és Molekuláris Biológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Korcsmáros T. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31951820" target="_blank">Autophagy-dependent survival is controlled with a unique regulatory network upon various cellular stress events</a></div> <div> <span class="journal-title">CELL DEATH AND DISEASE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-4889">2041-4889</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2041-4889">2041-4889</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">4</span> <span class="page"> Paper 309. 11 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41419-021-03599-7" target="_blank" href="https://doi.org/10.1038/s41419-021-03599-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000632883600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000632883600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85103157094" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85103157094"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33758166" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33758166&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 23</span> | Független: 19 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 23 | Scopus jelölt:&nbsp;21 | WoS/Scopus jelölt:&nbsp;23 | DOI jelölt:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31951820&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31951820</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (ÚNKP-19-3-I-SE-81), (ÚNKP-20-4-I-SE-32), (STIA-20-KF), (FK-134267) </div> <div class="lastModified">Utolsó módosítás: 2022.02.01. 14:35 Vasvari Lilian (MTMT Központ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology [uNKP-19-3-I-SE-81]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development And Innovation Fund [uNKP-20-4-I-SE-32]; Semmelweis University [STIA-20-KF]; NKFIH [FK-134267]; Biotechnological and Biosciences Rese...</pre> </div></div>