https://m2.mtmt.hu/ hun 2026-09-21 13:32 JournalArticle 31937630 VALIDATED true 0 false 2026-09-15T15:14:46.108+0000 2021-06-02T09:28:21.678+0000 2021-03-30T08:09:35.036+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin true 2022-03-03T14:38:48.077+0000 2022-03-03T14:38:48.077+0000 2021-06-02T09:28:21.691+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kuck, K.-H. Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST) true true /api/journal/22765 REVIEWED true false 22765 false 22765 true 1099-5129 1532-2092 Journal FOREIGN 23 3 362 369 362 8 2021 AIMS: Delay of progression from paroxysmal to persistent atrial fibrillation (AF) is an important measure of long-term success of AF treatment. However, published data on the impact of catheter ablation on AF progression are limited. This study evaluates whether radiofrequency (RF) catheter ablation delays the progression of AF compared with antiarrhythmic drug (AAD) treatment using current AF management guidelines. METHODS: This prospective, randomized, controlled, two-arm, open-label trial was conducted at 29 hospitals and medical centres across 13 countries. Patients were randomized 1 : 1 to RF ablation or AAD treatment. The primary endpoint was the rate of persistent AF/atrial tachycardia (AT) at 3 years. RESULTS: After early study termination following slow enrolment, 255 (79%) of the planned 322 patients were enrolled (RF ablation, n = 128, AAD, n = 127); 36% of patients in the RF ablation group and 41% in the AAD group completed 3 years of follow-up. For the primary endpoint, the Kaplan-Meier estimate of the rate of persistent AF/AT at 3 years was significantly lower with RF ablation [2.4% (95% confidence interval (CI), 0.6-9.4%)] than with AAD therapy [17.5% (95% CI, 10.7-27.9%); one-sided P = 0.0009]. Patients ≥65 years were ∼4 times more likely to progress to persistent AF/AT than patients <65 years, suggesting RF ablation can delay disease progression [hazard ratio: 3.87 (95% CI, 0.88-17.00); P = 0.0727]. Primary adverse events were reported for eight patients in the RF ablation group. CONCLUSIONS: Radiofrequency ablation is superior to guideline-directed AAD therapy in delaying the progression from paroxysmal to persistent AF. © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. true true 2021 true true true false true false NONE 2026-09-15 false 219 0 219 203 2 218 217 194 210 219 219 203 203 203 16 0 219 203 219 203 0 0 0 Folyóiratcikk Journal Article 24 217 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 10 6 10 6 2022 0 37 33 37 33 2023 0 37 34 37 34 2024 0 58 58 58 58 2025 0 53 50 53 50 2026 0 24 22 24 22 Q1 false 10013950 false false false 2021-03-29T08:31:58.527+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 1 16 2 14 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 95813762 /api/authorship/95813762 1 0.071428575 true false true Kuck K.-H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813763 /api/authorship/95813763 2 0.071428575 false false false Lebedev D.S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813764 /api/authorship/95813764 3 0.071428575 false false false Mikhaylov E.N. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813765 /api/authorship/95813765 4 0.071428575 false false false Romanov A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813766 /api/authorship/95813766 5 0.071428575 false false false Author 10013950 /api/author/10013950 Gellér László Alajos true 10013950 true Gellér L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813767 /api/authorship/95813767 6 0.071428575 false false false Kalējs O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813768 /api/authorship/95813768 7 0.071428575 false false false Neumann T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813769 /api/authorship/95813769 8 0.071428575 false false false Davtyan K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813770 /api/authorship/95813770 9 0.071428575 false false false On Y.K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813771 /api/authorship/95813771 10 0.071428575 false false false Popov S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813772 /api/authorship/95813772 11 0.071428575 false false false Bongiorni M.G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813773 /api/authorship/95813773 12 0.071428575 false false false Schlüter M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813774 /api/authorship/95813774 13 0.071428575 false false false Willems S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95813775 /api/authorship/95813775 14 0.071428575 false true false Ouyang F. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18581539 /api/publicationidentifier/18581539 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1093/europace/euaa298 https://doi.org/10.1093/europace/euaa298 false true PublicationIdentifier 18877987 /api/publicationidentifier/18877987 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000637048400006 https://www.webofscience.com/wos/woscc/full-record/000637048400006 true true PublicationIdentifier 18581538 /api/publicationidentifier/18581538 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85102908995 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85102908995 false true PublicationIdentifier 18581540 /api/publicationidentifier/18581540 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33330909 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33330909&dopt=Abstract false true Keyword 1016531 /api/keyword/1016531 true 1016531 true Keyword 1032351 /api/keyword/1032351 true 1032351 true Keyword 1115135 /api/keyword/1115135 true 1115135 true Keyword 1118492 /api/keyword/1118492 true 1118492 true Keyword 1516705 /api/keyword/1516705 true true SjrRating 11227921 /api/sjrrating/11227921 38 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q1 DIRECT true true /api/publication/31937630 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Kuck K.-H. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lebedev D.S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mikhaylov E.N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Romanov A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013950"><a href="/gui2/?type=authors&mode=browse&sel=10013950" target="_blank">Gellér L. (<span class="authorship-author-name">Gellér László Alajos</span> <span class="authorAux-mtmt"> Kardiológia, Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kalējs O. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neumann T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Davtyan K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >On Y.K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Popov S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bongiorni M.G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schlüter M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Willems S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ouyang F. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31937630" target="_blank">Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST)</a></div> <div> <span class="journal-title">EUROPACE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1099-5129">1099-5129</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2092">1532-2092</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">3</span> <span class="page"> pp 362-369 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/europace/euaa298" target="_blank" href="https://doi.org/10.1093/europace/euaa298"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000637048400006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000637048400006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85102908995" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85102908995"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33330909" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33330909&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 219</span> | Független: 203 | Függő: 16 | Nem jelölt: 0 | WoS jelölt: 194 | Scopus jelölt:&nbsp;210 | WoS/Scopus jelölt:&nbsp;219 | DOI jelölt:&nbsp;217 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31937630</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2021.06.02. 11:28 Molnár-Taga Márta (SE 4-es admin) </div> </div></div>