Pathophysiological adaptations of resistance arteries in rat offspring exposed in utero to maternal obesity is associated with sex-specific epigenetic alterations

https://m2.mtmt.hu/ hun 2026-09-21 21:42 JournalArticle 31932925 VALIDATED true 0 false 2026-05-20T17:10:32.117+0000 2022-02-08T15:35:01.845+0000 2021-03-26T12:32:38.591+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) true 2022-02-24T19:59:10.614+0000 2022-02-24T19:59:10.614+0000 2021-12-14T12:42:12.550+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Payen, Cyrielle Pathophysiological adaptations of resistance arteries in rat offspring exposed in utero to maternal obesity is associated with sex-specific epigenetic alterations true true /api/journal/2074 REVIEWED INTERNATIONAL JOURNAL OF OBESITY 0307-0565 1476-5497 true false 2074 false 2074 true 0307-0565 1476-5497 Journal FOREIGN 45 5 1074 1085 1074 12 2021 Background/objectives Maternal obesity impacts vascular functions linked to metabolic disorders in offspring, leading to cardiovascular diseases during adulthood. Even if the relation between prenatal conditioning of cardiovascular diseases by maternal obesity and vascular function begins to be documented, little is known about resistance arteries. They are of particular interest because of their specific role in the regulation of local blood flow. Then our study aims to determine if maternal obesity can directly program fetal vascular dysfunction of resistance arteries, independently of metabolic disorders. Methods With a model of rats exposed in utero to mild maternal diet-induced obesity (OMO), we investigated third-order mesenteric arteries of 4-month old rats in absence of metabolic disorders. The methylation profile of these vessels was determined by reduced representation bisulfite sequencing (RRBS). Vascular structure and reactivity were investigated using histomorphometry analysis and wire-myography. The metabolic function was evaluated by insulin and glucose tolerance tests, plasma lipid profile, and adipose tissue analysis. Results At 4 months of age, small mesenteric arteries of OMO presented specific epigenetic modulations of matrix metalloproteinases (MMPs), collagens, and potassium channels genes in association with an outward remodeling and perturbations in the endothelium-dependent vasodilation pathways (greater contribution of EDHFs pathway in OMO males compared to control rats, and greater implication of PGI(2) in OMO females compared to control rats). These vascular modifications were detected in absence of metabolic disorders. Conclusions Our study reports a specific methylation profile of resistance arteries associated with vascular remodeling and vasodilation balance perturbations in offspring exposed in utero to maternal obesity, in absence of metabolic dysfunctions. true true 2021 true true true false true false NONE 2026-05-20 false 10 0 10 7 3 9 10 10 10 10 10 7 7 7 3 0 10 7 10 7 0 0 0 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 0 1 0 2022 0 3 3 3 3 2023 0 1 1 1 1 2024 0 3 2 3 2 2025 0 1 0 1 0 2026 0 1 1 1 1 D1 B nemzetközi false false false false 2021-06-24T11:39:32.486+0000 Archeogenomikai Intézet (HRN BTK); Enzimológiai Intézet (TTK); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 2 27 3 12 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 95792618 /api/authorship/95792618 Payen, Cyrielle 1 0.083333336 true false false Payen Cyrielle true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792619 /api/authorship/95792619 Guillot, Abigaelle* 2 0.083333336 true false Guillot Abigaelle true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792620 /api/authorship/95792620 Paillat, Lily 3 0.083333336 false false false Paillat Lily true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792621 /api/authorship/95792621 Fothi, Abel [Fóthi, Ábel (genetika), szerző] Enzimológiai Intézet (TTK); Archeogenomikai Intézet (HRN BTK) 4 0.083333336 false false false Author 10067874 /api/author/10067874 Fóthi Ábel (genetika) Fóthi Ábel true true Fothi Abel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792622 /api/authorship/95792622 Dib, Abdallah 5 0.083333336 false false false Dib Abdallah true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792623 /api/authorship/95792623 Bourreau, Jennifer 6 0.083333336 false false false Bourreau Jennifer true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792624 /api/authorship/95792624 Schmitt, Francoise 7 0.083333336 false false false Schmitt Francoise true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792625 /api/authorship/95792625 Loufrani, Laurent 8 0.083333336 false false false Loufrani Laurent true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792626 /api/authorship/95792626 Aranyi, Tamas [Arányi, Tamás (Génexpresszió sza...), szerző] Enzimológiai Intézet (TTK); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 9 0.083333336 false false false Author 10012617 /api/author/10012617 Arányi Tamás (Génexpresszió szabályozás) Arányi Tamás true 10012617 true Aranyi Tamas true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792627 /api/authorship/95792627 Henrion, Daniel 10 0.083333336 false false false Henrion Daniel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792628 /api/authorship/95792628 Munier, Mathilde 11 0.083333336 false false false Munier Mathilde true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95792629 /api/authorship/95792629 Fassot, Celine ✉ 12 0.083333336 false true true Fassot Celine true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18570369 /api/publicationidentifier/18570369 DOI: 10.1038/s41366-021-00777-7 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1038/s41366-021-00777-7 https://doi.org/10.1038/s41366-021-00777-7 false true PublicationIdentifier 18570370 /api/publicationidentifier/18570370 WoS: 000622229200002 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000622229200002 https://www.webofscience.com/wos/woscc/full-record/000622229200002 false true PublicationIdentifier 18570372 /api/publicationidentifier/18570372 Scopus: 85101737477 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85101737477 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85101737477 false true PublicationIdentifier 18570371 /api/publicationidentifier/18570371 PubMed: 33637953 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33637953 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33637953&dopt=Abstract false true Keyword 1304618 /api/keyword/1304618 Endocrinology & Metabolism true 1304618 true MtaRating 11507751 /api/mtarating/11507751 IX. 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(2021) INTERNATIONAL JOURNAL OF OBESITY 0307-0565 1476-5497 45 5 1074-1085<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Payen Cyrielle </span> ;    <span class="author-name" >Guillot Abigaelle<sup>*</sup> </span> ;    <span class="author-name" >Paillat Lily </span> ;    <span class="author-name" mtid="10067874"><a href="/gui2/?type=authors&mode=browse&sel=10067874" target="_blank">Fothi Abel (<span class="authorship-author-name">Fóthi Ábel</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Bölcsészettudományi Kutatóközpont">BTK</span>/Archeogenomikai Intézet</span> ;    <span class="author-name" >Dib Abdallah </span> ;    <span class="author-name" >Bourreau Jennifer </span> ;    <span class="author-name" >Schmitt Francoise </span> ;    <span class="author-name" >Loufrani Laurent </span> ;    <span class="author-name" mtid="10012617"><a href="/gui2/?type=authors&mode=browse&sel=10012617" target="_blank">Aranyi Tamas (<span class="authorship-author-name">Arányi Tamás</span> <span class="authorAux-mtmt"> Génexpresszió szabályozás</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;    <span class="author-name" >Henrion Daniel </span> ;    <span class="author-name" >Munier Mathilde </span> ;    <span class="author-name" >Fassot Celine ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31932925" target="_blank">Pathophysiological adaptations of resistance arteries in rat offspring exposed in utero to maternal obesity is associated with sex-specific epigenetic alterations</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF OBESITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0307-0565">0307-0565</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-5497">1476-5497</a>)</span>: <span class="journal-volume">45</span> <span class="journal-issue">5</span> <span class="page"> pp 1074-1085 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41366-021-00777-7" target="_blank" href="https://doi.org/10.1038/s41366-021-00777-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000622229200002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000622229200002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85101737477" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85101737477"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33637953" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33637953&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nutrition and Dietetics   SJR indikátor: D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism   SJR indikátor: Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)   SJR indikátor: Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]   B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 7 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt: 10 | WoS/Scopus jelölt: 10 | DOI jelölt: 10 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31932925</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2022.02.08. 16:35 Fóthi Ábel (genetika) </div> </div></div>