https://m2.mtmt.hu/ hun 2026-05-30 09:58 JournalArticle 31930771 VALIDATED true Cited By :3 Export Date: 19 October 2022 CODEN: ADTHE Correspondence Address: Farsang, C.; Semmelweis University Pharmacology and Therapeutics and St. Imre University Teaching HospitalHungary; email: hunghyp@t-online.hu Chemicals/CAS: cholesterol, 57-88-5; creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; indapamide, 26807-65-8; perindopril, 82834-16-0, 99149-83-4; potassium, 7440-09-7; sodium, 7440-23-5; uric acid, 69-93-2; Antihypertensive Agents; Drug Combinations; Indapamide; Perindopril 0 false 2026-05-28T09:47:20.127+0000 2025-11-20T13:48:26.543+0000 2021-03-25T09:48:28.196+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin Kondor Zóra (SE_KK_Admin5_KZ, admin) true 2025-11-20T13:48:26.124+0000 2024-07-02T20:58:47.739+0000 true 10064150 Nagy Mária /api/admin/10064150 Admin Nagy Mária (SZE Szakreferens, admin) true 10064150 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Farsang, Csaba true true /api/journal/153 REVIEWED ADVANCES IN THERAPY 0741-238X 1865-8652 true false 153 false 153 true 0741-238X 1865-8652 Journal FOREIGN 38 4 1776 1790 1776 15 2021 Introduction To assess real-life effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in patients with hypertension (HT) and type 2 diabetes mellitus (T2DM), obesity and/or metabolic syndrome (MetS). Methods This post hoc analysis pooled raw data from four large observational studies (FORTISSIMO, FORSAGE, ACES, PICASSO). Patients, most with uncontrolled blood pressure (BP) on previous treatments were switched to Per/Ind (10 mg/2.5 mg) SPC at study entry. Office systolic and diastolic blood pressures (SBP and DBP) were measured at baseline, 1 month and 3 months. Results In the overall pooled population (N = 16,763), mean age was 61 +/- 12 years, HT duration 11 +/- 8 years, and baseline SBP/DBP 162/94 mmHg. T2DM, obesity and MetS were present in 21%, 49% and 27% of patients, respectively. Subgroups had similar mean age and HT duration to the overall population; patients with T2DM were slightly older (64 +/- 10 years) with a longer HT duration (13 +/- 8 years). Mean BP was approximately 160/95 mmHg in each subgroup. At 1 month, mean SBP decreased by approximately 20 mmHg in the overall population, and by a further 10 mmHg at 3 months. Similar results were observed in the three subgroups, with mean changes from baseline at 3 months of - 28 +/- 15/- 13 +/- 10 in T2DM; - 30 +/- 15/- 14 +/- 10 in obesity; and - 31 +/- 15/- 15 +/- 9 mmHg in MetS. BP decreases were greatest in patients with grade II or grade III HT. BP control rates (< 140/90 mmHg or 140/85 mmHg for T2DM) at 3 months were 59% in T2DM, 67% in obese, and 66% in MetS. No specific safety concerns were raised, particularly concerning ionic (Na, K) or metabolic profiles. Conclusions Switching to Per/Ind SPC led to rapid and effective BP decreases in patients with T2DM, obesity, or MetS. BP control was achieved in 6-7 out of 10 previously treated but uncontrolled patients. Treatment was well tolerated. The results confirm the beneficial effects of a Per/Ind SPC for difficult-to-control patient populations. Funding 2008872 /api/funding/2008872 (Open access funding of Semmelweis University) false true true 2021 true true true false true false NONE 2026-05-28 false 3 0 3 3 0 3 3 3 2 3 3 3 3 3 0 0 3 3 3 3 0 3 3 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 2 2 2 2 2023 0 1 1 1 1 Q1 false false false false 2021-06-23T08:55:50.641+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 2 19 1 6 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 95782116 /api/authorship/95782116 Farsang, Csaba ✉ [Farsang, Csaba (Vérnyomásszabályo...), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 1 0.16666667 true false true Author 10000365 /api/author/10000365 Farsang Csaba (Vérnyomásszabályozás, cardiologia, nephrologia, belgyógyászat) Farsang Csaba true 10000365 true Farsang Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95782117 /api/authorship/95782117 Dezsi, Csaba Andras [Dézsi, Csaba András (Belgyógyászat, ka...), szerző] 2 0.167 false false false Author 10050815 /api/author/10050815 Dézsi Csaba András (Belgyógyászat, kardiológia) Dézsi Csaba András true 10050815 true Dezsi Csaba Andras true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95782118 /api/authorship/95782118 Brzozowska-Villatte, Romualda 3 0.16666667 false false false Brzozowska-Villatte Romualda true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95782119 /api/authorship/95782119 De, Champvallins Martine 4 0.16666667 false false false De Champvallins Martine true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95782120 /api/authorship/95782120 Glezer, Maria 5 0.16666667 false false false Glezer Maria true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95782121 /api/authorship/95782121 Karpov, Yuri 6 0.16666667 false true false Karpov Yuri true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18563915 /api/publicationidentifier/18563915 DOI: 10.1007/s12325-021-01619-8 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 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(2021) ADVANCES IN THERAPY 0741-238X 1865-8652 38 4 1776-1790<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000365"><a href="/gui2/?type=authors&mode=browse&sel=10000365" target="_blank">Farsang Csaba ✉ (<span class="authorship-author-name">Farsang Csaba</span> <span class="authorAux-mtmt"> Vérnyomásszabályozás, cardiologia, nephrologia,...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050815"><a href="/gui2/?type=authors&mode=browse&sel=10050815" target="_blank">Dezsi Csaba Andras (<span class="authorship-author-name">Dézsi Csaba András</span> <span class="authorAux-mtmt"> Belgyógyászat, kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brzozowska-Villatte Romualda </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >De Champvallins Martine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Glezer Maria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Karpov Yuri </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31930771" target="_blank">Beneficial Effects of a Perindopril/Indapamide Single-Pill Combination in Hypertensive Patients with Diabetes and/or Obesity or Metabolic Syndrome: A Post Hoc Pooled Analysis of Four Observational Studies</a></div> <div> <span class="journal-title">ADVANCES IN THERAPY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0741-238X">0741-238X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1865-8652">1865-8652</a>)</span>: <span class="journal-volume">38</span> <span class="journal-issue">4</span> <span class="page"> pp 1776-1790 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s12325-021-01619-8" target="_blank" href="https://doi.org/10.1007/s12325-021-01619-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000621694600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000621694600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85101764822" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85101764822"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="33630277" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33630277&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101764822&doi=10.1007%2Fs12325-021-01619-8&partnerID=40&md5=807051c2a0bb4f6de9f1b6d22b3ad94a" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101764822&doi=10.1007%2Fs12325-021-01619-8&partnerID=40&md5=807051c2a0bb4f6de9f1b6d22b3ad94a"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 3 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31930771&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31930771</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (Open access funding of Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2025.11.20. 14:48 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :3 Export Date: 19 October 2022 CODEN: ADTHE Correspondence Address: Farsang, C.; Semmelweis University Pharmacology and Therapeutics and St. Imre University Teaching HospitalHungary; email: hunghyp@t-online.hu Chemicals/CAS: cholesterol, 57-88-5; creatinine, 19230-81-0, 60-27-5; glucose, 50...</pre> </div></div>