https://m2.mtmt.hu/ eng 2026-10-25 04:52 JournalArticle 31925393 VALIDATED true Lajtai K, Tarszabó R, Horváth EM, Masszi G, and Várbíró S contributed equally to this work 0 false 2026-10-21T05:06:14.139+0000 2025-08-26T12:37:41.188+0000 2021-03-21T21:12:44.604+0000 true 10023667 Galamb Ádám /api/admin/10023667 Admin true 10023667 2024-09-09T19:11:51.679+0000 2022-06-25T12:06:13.615+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Lajtai, K. Effect of Vitamin D Status on Vascular Function of the Aorta in a Rat Model of PCOS true true /api/journal/10011773 REVIEWED true false 10011773 false 10011773 true 1942-0900 1942-0994 Journal FOREIGN 2021 8865979 8865979 6 2021 Polycystic ovary syndrome (PCOS) is associated with elevated cardiovascular risk. Early vascular dysfunction may lead to the development of cardiovascular disease in PCOS. Vitamin D deficiency (VDD) is a common comorbidity of PCOS that contributes to the pathogenesis of the disease and its complications. Both PCOS and VDD are accompanied by increased oxidative stress that may be involved in the arising vascular dysfunction. We aimed to investigate the role of vitamin D status on aortic function. PCOS was induced by an 8-week-long transdermal testosterone treatment of female rats, and low and adequate vitamin D status was achieved by dietary means. Contraction and relaxation abilities of isolated aortic segments were measured by myograph. Resorcin-fuchsin staining and immunohistochemical labeling of 3-nitrotyrosine were performed. No difference was shown in the norepinephrine-induced contraction of the aortas of different groups, whereas we detected reduced acetylcholine- and insulin-evoked relaxation in VDD groups. A lower level of resorcin-fuchsin staining and elevated 3-nitrotyrosine immunostaining was observed in VDD. In our study, we demonstrated early endothelial dysfunction in VDD PCOS rat model. Vitamin D supplementation could prevent vascular disturbances, while VDD itself damaged endothelium-dependent vasorelaxation and induced nitrative stress. Funding 2008833 /api/funding/2008833 false true Funding 2008834 /api/funding/2008834 false true Funding 2008835 /api/funding/2008835 false true Funding 2008836 /api/funding/2008836 false true Funding 2008837 /api/funding/2008837 false true Funding 2008838 /api/funding/2008838 false true true true 2021 true true true false true false GOLD 2026-10-21 true https://doi.org/10.1155/2021/8865979 16 0 16 10 6 16 16 14 14 16 16 10 10 10 6 0 16 10 16 10 0 6 6 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 4 1 4 1 2022 0 4 3 4 3 2023 0 3 2 3 2 2024 0 1 1 1 1 2025 0 3 2 3 2 2026 0 1 1 1 1 Q1 false 10025626,10009921,10075334,10065600,10027020 false false false 2021-04-15T08:14:03.873+0000 Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 13 34 4 14 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 95752200 /api/authorship/95752200 1 0.071 true false true Author 10061648 /api/author/10061648 Lajtai Krisztina true 10061648 true Lajtai K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752201 /api/authorship/95752201 2 0.071 true false true Author 10036698 /api/author/10036698 Tarszabó Róbert true 10036698 true Tarszabó R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752202 /api/authorship/95752202 3 0.071428575 false false false Author 10075180 /api/author/10075180 Bányai Bálint Péter true true Bányai B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752203 /api/authorship/95752203 4 0.071428575 false false false Author 10077542 /api/author/10077542 Péterffy Borbála true true Péterffy B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752204 /api/authorship/95752204 5 0.071 false false false Author 10075334 /api/author/10075334 Gerszi Dóra true true Gerszi D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752205 /api/authorship/95752205 6 0.071428575 false false false Author 10025626 /api/author/10025626 Ruisanchez Éva true 10025626 true Ruisanchez É. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752206 /api/authorship/95752206 7 0.071 false false false Author 10065600 /api/author/10065600 Sziva Réka Eszter true true Sziva R. E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752207 /api/authorship/95752207 8 0.071428575 false false false Author 10081348 /api/author/10081348 Korsós-Novák Ágnes true true Korsós-Novák Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752208 /api/authorship/95752208 9 0.071428575 false false false Author 10022169 /api/author/10022169 Benkő Rita true 10022169 true Benkő R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752209 /api/authorship/95752209 10 0.071428575 false false false Author 10027020 /api/author/10027020 Hadjadj Leila true 10027020 true Hadjadj L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752210 /api/authorship/95752210 11 0.071428575 false false false Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyó Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752211 /api/authorship/95752211 12 0.071 false true false Author 10020503 /api/author/10020503 Horvath Eszter Mária true 10020503 true Horváth E. M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752212 /api/authorship/95752212 13 0.071 false true false Masszi G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95752213 /api/authorship/95752213 14 0.071 false true false Author 10011316 /api/author/10011316 Várbíró Szabolcs true 10011316 true Várbíró S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18551150 /api/publicationidentifier/18551150 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1155/2021/8865979 https://doi.org/10.1155/2021/8865979 false true PublicationIdentifier 18696443 /api/publicationidentifier/18696443 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000636293800001 https://www.webofscience.com/wos/woscc/full-record/000636293800001 true true PublicationIdentifier 18659812 /api/publicationidentifier/18659812 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85103679911 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85103679911 true true PublicationIdentifier 18659805 /api/publicationidentifier/18659805 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33791074 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33791074&dopt=Abstract true true Classification 11608 /api/classification/11608 true true Classification 12284 /api/classification/12284 true true SjrRating 11196169 /api/sjrrating/11196169 87 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/31925393 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061648"><a href="/gui2/?type=authors&mode=browse&sel=10061648" target="_blank">Lajtai K. ✉ (<span class="authorship-author-name">Lajtai Krisztina</span> <span class="authorAux-mtmt"> Szülészet - nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036698"><a href="/gui2/?type=authors&mode=browse&sel=10036698" target="_blank">Tarszabó R.<sup>*</sup> ✉ (<span class="authorship-author-name">Tarszabó Róbert</span> <span class="authorAux-mtmt"> Kórélettan - nőgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075180"><a href="/gui2/?type=authors&mode=browse&sel=10075180" target="_blank">Bányai B. (<span class="authorship-author-name">Bányai Bálint Péter</span> <span class="authorAux-mtmt"> Élettan, Transzlációs medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077542"><a href="/gui2/?type=authors&mode=browse&sel=10077542" target="_blank">Péterffy B. (<span class="authorship-author-name">Péterffy Borbála</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075334"><a href="/gui2/?type=authors&mode=browse&sel=10075334" target="_blank">Gerszi D. (<span class="authorship-author-name">Gerszi Dóra</span> <span class="authorAux-mtmt"> szülészet - nőgyógyászat, élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025626"><a href="/gui2/?type=authors&mode=browse&sel=10025626" target="_blank">Ruisanchez É. (<span class="authorship-author-name">Ruisanchez Éva</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065600"><a href="/gui2/?type=authors&mode=browse&sel=10065600" target="_blank">Sziva R. E. (<span class="authorship-author-name">Sziva Réka Eszter</span> <span class="authorAux-mtmt"> Szülészet-Nőgyógyászat, Nőgyógyászati endokrino...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081348"><a href="/gui2/?type=authors&mode=browse&sel=10081348" target="_blank">Korsós-Novák Á. (<span class="authorship-author-name">Korsós-Novák Ágnes</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022169"><a href="/gui2/?type=authors&mode=browse&sel=10022169" target="_blank">Benkő R. (<span class="authorship-author-name">Benkő Rita</span> <span class="authorAux-mtmt"> Humán és orvosi biológia, élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027020"><a href="/gui2/?type=authors&mode=browse&sel=10027020" target="_blank">Hadjadj L. (<span class="authorship-author-name">Hadjadj Leila</span> <span class="authorAux-mtmt"> Aneszteziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Z. (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020503"><a href="/gui2/?type=authors&mode=browse&sel=10020503" target="_blank">Horváth E. M.<sup>**</sup> (<span class="authorship-author-name">Horvath Eszter Mária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Masszi G.<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró S. (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31925393" target="_blank">Effect of Vitamin D Status on Vascular Function of the Aorta in a Rat Model of PCOS</a></div> <div> <span class="journal-title">OXIDATIVE MEDICINE AND CELLULAR LONGEVITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0900">1942-0900</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0994">1942-0994</a>)</span>: <span class="journal-volume">2021</span> <span class="page"> Paper 8865979. 6 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2021/8865979" target="_blank" href="https://doi.org/10.1155/2021/8865979"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000636293800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000636293800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85103679911" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85103679911"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33791074" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33791074&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 16</span> | Independent citation: 10 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;16 | Number of citations with DOI:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31925393&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31925393</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> Dean of the Medical Faculty, Semmelweis University, (PD_132851), (K-125174) Funder: NR-DIO, (Molecular Biology Thematic Programme of Semmelweis University), (Fight for the Women’s Hearts Medical Foundation), Hungarian Hypertension Society </div> <div class="lastModified">Last Modified: 2025.08.26. 14:37 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Lajtai K, Tarszabó R, Horváth EM, Masszi G, and Várbíró S contributed equally to this work</pre> </div></div>