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This work was supported by grants from the National Natural Science Foundation of China ( 31630090 and 31825014 ) and the National Key R&D Program of China ( 2016YFA0500402 and 2015CB910102 ) to B.X., who is an awardee of the National Science Fund for Distinguished Young Scholars .", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-07-29T17:45:17.150+0000", "lastModified" : "2022-01-11T10:24:59.029+0000", "created" : "2021-03-10T19:34:21.993+0000", "creator" : { "otype" : "Admin", "mtid" : 10065463, "link" : "/api/admin/10065463", "label" : "Turek Márta (KOKI admin 4)", "familyName" : "Turek", "givenName" : "Márta", "published" : true, "snippet" : true }, "lastDuplumSearch" : "2024-02-01T13:38:35.395+0000", "validated" : "2021-10-06T04:02:34.043+0000", "validator" : { "otype" : "Admin", "mtid" : 10067876, "link" : "/api/admin/10067876", "label" : "MTMT API (MTMT API user, admin)", "familyName" : "MTMT", "givenName" : "API", "published" : true, "snippet" : true }, "core" 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Piezo1/2 possess a unique 38-transmembrane (TM) helix topology and form a homotrimeric propeller-shaped structure comprising a central ion-conducting pore and three peripheral mechanosensing blades. The unusually curved TM region of the three blades shapes a signature nano-bowl configuration with potential to generate large in-plane membrane area expansion, which might confer exquisite mechanosensitivity to Piezo channels. 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Retailleau, K., Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling (2015) Cell Rep., 13, pp. 1161-1171", "listPosition" : 19, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923236, "link" : "/api/reference/18923236", "label" : "20. Friedrich, E.E., Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions (2019) Proc. Natl. Acad. Sci. U. S. A., 116, pp. 12980-12985", "listPosition" : 20, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923235, "link" : "/api/reference/18923235", "label" : "21. Rode, B., Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance (2017) Nat. Commun., 8, p. 350", "listPosition" : 21, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923234, "link" : "/api/reference/18923234", "label" : "22. Wang, S., Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release (2016) J. Clin. Invest., 126, pp. 4527-4536", "listPosition" : 22, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923233, "link" : "/api/reference/18923233", "label" : "23. Nonomura, K., Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation (2018) Proc. Natl. Acad. Sci. U. S. A., 115, pp. 12817-12822", "listPosition" : 23, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923232, "link" : "/api/reference/18923232", "label" : "24. Li, S., Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families (2018) BMC Med. Genet., 19, p. 179", "listPosition" : 24, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923231, "link" : "/api/reference/18923231", "label" : "25. Del Orbe Barreto, R., Hereditary xerocytosis, a misleading anemia (2016) Ann. Hematol., 95, pp. 1545-1546", "listPosition" : 25, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923230, "link" : "/api/reference/18923230", "label" : "26. Moura, P.L., PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis (2020) Haematologica, 105, pp. e268-e271", "listPosition" : 26, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923229, "link" : "/api/reference/18923229", "label" : "27. Rotordam, M.G., A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp (2019) Haematologica, 104, pp. e179-e183", "listPosition" : 27, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923228, "link" : "/api/reference/18923228", "label" : "28. 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Blood Cancer, 64", "listPosition" : 31, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923224, "link" : "/api/reference/18923224", "label" : "32. Andolfo, I., PIEZO1-R1864H rare variant accounts for a genetic phenotype-modifier role in dehydrated hereditary stomatocytosis (2018) Haematologica, 103, pp. e94-e97", "listPosition" : 32, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923223, "link" : "/api/reference/18923223", "label" : "33. Andolfo, I., PIEZO1 hypomorphic variants in congenital lymphatic dysplasia cause shape and hydration alterations of red blood cells (2019) Front. Physiol., 10, p. 258", "listPosition" : 33, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 18923222, "link" : "/api/reference/18923222", "label" : "34. Delle Vedove, A., Biallelic loss of proprioception-related PIEZO2 causes muscular atrophy with perinatal respiratory distress, arthrogryposis, and scoliosis (2016) Am. J. 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