https://m2.mtmt.hu/ hun 2026-09-21 05:43 JournalArticle 31905067 VALIDATED true Institute and Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia Scientific Centre of Excellence for Personalized Health Care, University of Josip Juraj Strossmayer University of Osijek, Osijek, Croatia Department of Dermatology and Venereology, University Hospital Centre Osijek, Osijek, Croatia Department of Heart and Vascular Diseases, University Hospital Centre Osijek, Osijek, Croatia Department of Internal Medicine, Faculty of Medicine, University of Josip Juraj Strossmayer Osijek, Osijek, Croatia Department of Nephrology, University Hospital Centre Osijek, Osijek, Croatia Department of Neurosurgery, Szentagothai Research Centre, University of Pecs, Pecs, Hungary Department of Morphology and Physiology, Semmelweis University, Budapest, Hungary Sport-Physiology Research Centre, University of Physical Education, Budapest, Hungary Department of Physiology, New York Medical College, Valhalla, NY, United States Radiation Chemistry and Dosimetry Laboratory, Division of Materials Chemistry, Ruder Boskovic Institute, Zagreb, Croatia Cited By :10 Export Date: 28 February 2025 CODEN: AJPPD Correspondence Address: Drenjancevic, I.; Institute and Department of Physiology and Immunology, Croatia; email: ines.drenjancevic@mefos.hr Chemicals/CAS: 8 isoprostaglandin F2 alpha, 27415-26-5; acetylcholine, 51-84-3, 60-31-1, 66-23-9; angiotensin II, 11128-99-7, 68521-88-0; catalase, 9001-05-2; endothelial nitric oxide synthase, 503473-02-7; indometacin, 53-86-1, 74252-25-8, 7681-54-1; inducible nitric oxide synthase, 501433-35-8; losartan, 114798-26-4; n(g) nitroarginine methyl ester, 50903-99-6; nitric oxide, 10102-43-9; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; tempol, 2226-96-2; Angiotensin II Type 1 Receptor Blockers; Antioxidants; Cell Adhesion Molecules; Cytokines; Inflammation Mediators; Nitric Oxide; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Vasodilator Agents Funding details: K 132596 Funding details: Hrvatska Zaklada za Znanost, HRZZ, IP-2014-09-6380 Funding details: Hrvatska Zaklada za Znanost, HRZZ Funding text 1: This work has been supported by the Croatian Science Foundation Project Grant IP-2014-09-6380 (to I. Drenjancević, principal investigator) and National Research, Development and Innovation Fund OTKA K 132596 (to A. Koller, principal investigator). 0 false 2026-07-11T08:33:06.160+0000 2026-07-10T16:47:34.343+0000 2021-03-08T13:22:32.179+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-07-11T08:31:41.196+0000 2024-11-28T05:57:11.778+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Jukic, Ivana Angiotensin II type 1 receptor is involved in flow-induced vasomotor responses of isolated middle cerebral arteries. Role of oxidative stress true true /api/journal/21227 REVIEWED true false 21227 false 21227 true 0363-6135 1522-1539 Journal FOREIGN 320 4 H1609 H1624 H1609 16 2021 This study aimed to determine the mechanosensing role of angiotensin II type 1 receptor (AT1R) in flow-induced dilation (FID) and oxidative stress production in middle cerebral arteries (MCA) of Sprague-Dawley rats. Eleven-weeks old, healthy male Sprague-Dawley rats on a standard diet were given the AT1R blocker losartan (1 mg/mL) in drinking water (losartan group) or tap water (control group) ad libitum for 7 days. Blockade of AT1R attenuated FID and acetylcholine-induced dilations was compared to control group. Nitric oxide (NO) synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME) and cyclooxygenase inhibitor indomethacin (INDO) significantly reduced FID in control group. The attenuated FID in losartan group was further reduced by INDO only at ∆100 mmHg, whereas L-NAME had no effect. In losartan group, TEMPOL (a superoxide scavenger) restored dilatation, while TEMPOL+L-NAME together significantly reduced FID compared to restored dilatation with TEMPOL alone. Direct fluorescence measurements of NO and reactive oxygen species (ROS) production in MCA, in no-flow conditions revealed significantly reduced vascular NO levels with AT1R blockade compared to control group, while flow increased the NO and ROS production in losartan group and had no effect in control group. In losartan group, TEMPOL decreased ROS production in both no-flow and flow conditions. AT1R blockade elicited increased serum concentrations of AngII, 8-iso-PGF2α, and TBARS, and decreased antioxidant enzyme activity (SOD and CAT). These results suggest that in small isolated cerebral arteries: 1) AT1 receptor maintains dilations in physiological conditions; 2) AT1R blockade leads to increased vascular and systemic oxidative stress, which underlies impaired FID. 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Keringéskutató Laboratórium (PTE / SZKK); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Természettudományi Intézet (TE) 1 26 4 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 95643846 /api/authorship/95643846 1 0.1 true false false Jukic Ivana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643847 /api/authorship/95643847 2 0.1 false false false Mihaljevic Zrinka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643848 /api/authorship/95643848 3 0.1 false false false Matic Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643849 /api/authorship/95643849 4 0.1 false false false Mihalj Martina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643850 /api/authorship/95643850 5 0.1 false false false Kozina Natasa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643851 /api/authorship/95643851 6 0.1 false false false Selthofer-Relatic Kristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643852 /api/authorship/95643852 7 0.1 false false false Mihaljevic Dubravka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643853 /api/authorship/95643853 8 0.1 false false false Author 10002221 /api/author/10002221 Koller Ákos true 10002221 true Koller Akos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643854 /api/authorship/95643854 9 0.1 false false false Tartaro Bujak Ivana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95643855 /api/authorship/95643855 10 0.1 false true true Drenjancevic Ines true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18508347 /api/publicationidentifier/18508347 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY IDENTICAL 10.1152/ajpheart.00620.2020 https://doi.org/10.1152/ajpheart.00620.2020 false true PublicationIdentifier 18839946 /api/publicationidentifier/18839946 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000642282900030 https://www.webofscience.com/wos/woscc/full-record/000642282900030 false true PublicationIdentifier 18710581 /api/publicationidentifier/18710581 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85104047358 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85104047358 false true PublicationIdentifier 18508346 /api/publicationidentifier/18508346 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33666506 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33666506&dopt=Abstract false true Keyword 435 /api/keyword/435 true 435 true Keyword 15123 /api/keyword/15123 true 15123 true Keyword 1017301 /api/keyword/1017301 true 1017301 true Keyword 1038254 /api/keyword/1038254 true 1038254 true Keyword 2014641 /api/keyword/2014641 true true SjrRating 11227937 /api/sjrrating/11227937 50 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q1 DIRECT true true /api/publication/31905067 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Jukic Ivana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mihaljevic Zrinka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matic Anita </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mihalj Martina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kozina Natasa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Selthofer-Relatic Kristina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mihaljevic Dubravka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002221"><a href="/gui2/?type=authors&mode=browse&sel=10002221" target="_blank">Koller Akos (<span class="authorship-author-name">Koller Ákos</span> <span class="authorAux-mtmt"> Szív és vérkeringés</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Idegsebészeti Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Morfológiai és Fiziológiai Tanszék; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Keringéskutató Laboratórium; <span title="Testnevelési Egyetem">TE</span>/Természettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tartaro Bujak Ivana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Drenjancevic Ines ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31905067" target="_blank">Angiotensin II type 1 receptor is involved in flow-induced vasomotor responses of isolated middle cerebral arteries. Role of oxidative stress</a></div> <div> <span class="journal-title">AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0363-6135">0363-6135</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1522-1539">1522-1539</a>)</span>: <span class="journal-volume">320</span> <span class="journal-issue">4</span> <span class="page"> pp H1609-H1624 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1152/ajpheart.00620.2020" target="_blank" href="https://doi.org/10.1152/ajpheart.00620.2020"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000642282900030" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000642282900030"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85104047358" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85104047358"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33666506" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33666506&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 6 | Függő: 7 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;13 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31905067&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31905067</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (K132596) Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2026.07.10. 18:47 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute and Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia Scientific Centre of Excellence for Personalized Health Care, University of Josip Juraj Strossmayer University of Osijek, Osijek, Croatia Department of Dermatology and Venereology, University Hospital Cen...</pre> </div></div>