https://m2.mtmt.hu/ hun 2026-05-01 01:05 JournalArticle 3190054 VALIDATED true Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudosok krt. 2, Budapest, 1117, Hungary 2nd Department of Pathology, Faculty of Medicine, Semmelweis University, Ulloi ut 26., Budapest, 1085, Hungary Molecular Oncology Research Group of the Hungarian Academy of Sciences and Semmelweis University, Ulloi ut 26., Budapest, 1085, Hungary MTA-SE Molecular Biophysics Research Group, Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-43., Budapest, 1094, Hungary Cited By :22 Export Date: 10 February 2024 CODEN: CECAD Correspondence Address: Sarkadi, B.; Institute of Enzymology, Magyar Tudosok krt. 2, Hungary; email: sarkadi@biomembrane.hu Chemicals/CAS: adenosine triphosphatase (calcium); hemoglobin, 9008-02-0; ATP2B4 protein, human; Hemoglobins; Plasma Membrane Calcium-Transporting ATPases 0 2018-08-23T22:21:24.000+0000 false 3190054 2026-04-29T11:55:19.268+0000 2023-07-07T09:46:06.238+0000 2017-02-23T08:46:51.000+0000 true 10015754 Várady György /api/author/10015754 Author true 10015754 2025-03-20T11:52:49.859+0000 2020-04-28T13:28:01.516+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Zambo, B Decreased calcium pump expression in human erythrocytes is connected to a minor haplotype in the ATP2B4 gene true true /api/journal/939 REVIEWED true false 939 false 939 true 0143-4160 1532-1991 Journal FOREIGN 65 73 79 73 7 2017 Plasma membrane Ca2+-ATPases are key calcium exporter proteins in most tissues, and PMCA4b is the main calcium transporter in the human red blood cells (RBCs). In order to assess the expression level of PMCA4b, we have developed a flow cytometry and specific antibody binding method to quantitatively detect this protein in the erythrocyte membrane. Interestingly, we found several healthy volunteers showing significantly reduced expression of RBC-PMCA4b. Western blot analysis of isolated RBC membranes confirmed this observation, and indicated that there are no compensatory alterations in other PMCA isoforms. In addition, reduced PMCA4b levels correlated with a lower calcium extrusion capacity in these erythrocytes. When exploring the potential genetic background of the reduced PMCA4b levels, we found no missense mutations in the ATP2B4 coding regions, while a formerly unrecognized minor haplotype in the predicted second promoter region closely correlated with lower erythrocyte PMCA4b protein levels. In recent GWA studies, SNPs in this ATP2B4 haplotype have been linked to reduced mean corpuscular hemoglobin concentrations (MCHC), and to protection against malaria infection. Our data suggest that an altered regulation of gene expression is responsible for the reduced RBC-PMCA4b levels that is probably linked to the development of human disease-related phenotypes. 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Patológiai Intézet (SE / AOK / I); MTA-SE Molekuláris Biofizikai Kutatócsoport (SE / AOK / I / BSI); MTA-SE Molekuláris Onkológia Kutatócsoport (SE / AOK / I / IISZPI) 8 52 4 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 8877664 /api/authorship/8877664 1 0.125 true false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zambo B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25653748 true PersonAuthorship 8877665 /api/authorship/8877665 2 0.125 false false Author 10015754 /api/author/10015754 Várady György true 10015754 true Varady G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25653747 true PersonAuthorship 8877666 /api/authorship/8877666 3 0.125 false false Author 10029020 /api/author/10029020 Padányi Rita true 10029020 true Padanyi R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25653746 true PersonAuthorship 8877667 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true true Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 25653741 true PublicationIdentifier 1178684 /api/publicationidentifier/1178684 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.ceca.2017.02.001 https://doi.org/10.1016/j.ceca.2017.02.001 false 1550648 true PublicationIdentifier 1178686 /api/publicationidentifier/1178686 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN true NO 74310 http://real.mtak.hu/74310 false 1719329 true PublicationIdentifier 1178687 /api/publicationidentifier/1178687 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zambo B (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Varady G (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029020"><a href="/gui2/?type=authors&mode=browse&sel=10029020" target="_blank">Padanyi R (<span class="authorship-author-name">Padányi Rita</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040526"><a href="/gui2/?type=authors&mode=browse&sel=10040526" target="_blank">Szabo E (<span class="authorship-author-name">Szabó Edit Zsuzsanna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043363"><a href="/gui2/?type=authors&mode=browse&sel=10043363" target="_blank">Nemeth A (<span class="authorship-author-name">Németh Adrienn</span> <span class="authorAux-mtmt"> molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054034"><a href="/gui2/?type=authors&mode=browse&sel=10054034" target="_blank">Lango T (<span class="authorship-author-name">Langó Tamás</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015745"><a href="/gui2/?type=authors&mode=browse&sel=10015745" target="_blank">Enyedi A (<span class="authorship-author-name">Enyedi Ágnes</span> <span class="authorAux-mtmt"> Biokémia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="II. Sz. Patológiai Intézet">IISZPI</span>/MTA-SE Molekuláris Onkológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi B ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biofizikai és Sugárbiológiai Intézet">BSI</span>/MTA-SE Molekuláris Biofizikai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3190054" target="_blank">Decreased calcium pump expression in human erythrocytes is connected to a minor haplotype in the ATP2B4 gene</a></div> <div> <span class="journal-title">CELL CALCIUM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0143-4160">0143-4160</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-1991">1532-1991</a>)</span>: <span class="journal-volume">65</span> <span class="page"> pp 73-79 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.ceca.2017.02.001" target="_blank" href="https://doi.org/10.1016/j.ceca.2017.02.001"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="74310" target="_blank" href="http://real.mtak.hu/74310"> REAL </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="5565" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/5565"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000403992700009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000403992700009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85013096162" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85013096162"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="28216081" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28216081&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 28</span> | Független: 23 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 26 | Scopus jelölt:&nbsp;27 | WoS/Scopus jelölt:&nbsp;28 | DOI jelölt:&nbsp;28 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3190054&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3190054</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3190054</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> (FIEK_16-1-2016-0005) </div> <div class="lastModified">Utolsó módosítás: 2023.07.07. 11:46 Csámer Iván (ELTE TTK kari admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudosok krt. 2, Budapest, 1117, Hungary 2nd Department of Pathology, Faculty of Medicine, Semmelweis University, Ulloi ut 26., Budapest, 1085, Hungary Molecular Oncology Research Group of the Hungarian Academy of Sciences and Semmelweis University,...</pre> </div></div>