https://m2.mtmt.hu/ eng 2026-05-30 13:57 JournalArticle 31898972 VALIDATED true 0 false 2026-05-29T12:39:25.976+0000 2024-12-06T17:57:37.021+0000 2021-03-03T11:46:54.124+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 2024-05-27T11:31:37.175+0000 2024-05-27T11:31:37.175+0000 2024-12-06T17:57:37.271+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bartha, Áron TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 22 5 2622 2622 12 2021 Genes showing higher expression in either tumor or metastatic tissues can help in better understanding tumor formation and can serve as biomarkers of progression or as potential therapy targets. Our goal was to establish an integrated database using available transcriptome-level datasets and to create a web platform which enables the mining of this database by comparing normal, tumor and metastatic data across all genes in real time. We utilized data generated by either gene arrays from the Gene Expression Omnibus of the National Center for Biotechnology Information (NCBIGEO) or RNA-seq from The Cancer Genome Atlas (TCGA), Therapeutically Applicable Research to Generate Effective Treatments (TARGET), and The Genotype-Tissue Expression (GTEx) repositories. The altered expression within different platforms was analyzed separately. Statistical significance was computed using Mann–Whitney or Kruskal–Wallis tests. False Discovery Rate (FDR) was computed using the Benjamini–Hochberg method. The entire database contains 56,938 samples, including 33,520 samples from 3180 gene chip-based studies (453 metastatic, 29,376 tumorous and 3691 normal samples), 11,010 samples from TCGA (394 metastatic, 9886 tumorous and 730 normal), 1193 samples from TARGET (1 metastatic, 1180 tumorous and 12 normal) and 11,215 normal samples from GTEx. The most consistently upregulated genes across multiple tumor types were TOP2A (FC = 7.8), SPP1 (FC = 7.0) and CENPA (FC = 6.03), and the most consistently downregulated gene was ADH1B (FC = 0.15). Validation of differential expression using equally sized training and test sets confirmed the reliability of the database in breast, colon, and lung cancer at an FDR below 10%. The online analysis platform enables unrestricted mining of the database and is accessible at TNMplot.com. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. 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Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 2 26 3 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 95613594 /api/authorship/95613594 1 0.5 true false Author 10072855 /api/author/10072855 Bartha Áron true true Bartha Áron true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95613595 /api/authorship/95613595 2 0.5 false true true Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18546488 /api/publicationidentifier/18546488 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms22052622 https://doi.org/10.3390/ijms22052622 false true PublicationIdentifier 18659075 /api/publicationidentifier/18659075 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000628278400001 https://www.webofscience.com/wos/woscc/full-record/000628278400001 true true PublicationIdentifier 18546487 /api/publicationidentifier/18546487 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85102005778 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85102005778 false true PublicationIdentifier 18659076 /api/publicationidentifier/18659076 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33807717 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33807717&dopt=Abstract true true Keyword 643 /api/keyword/643 true 643 true Keyword 1059 /api/keyword/1059 true 1059 true Keyword 1003852 /api/keyword/1003852 true 1003852 true Keyword 1024475 /api/keyword/1024475 true 1024475 true Keyword 1249048 /api/keyword/1249048 true 1249048 true SjrRating 11203857 /api/sjrrating/11203857 6 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1607 /api/classificationexternal/1607 true 1607 true D1 DIRECT true true /api/publication/31898972 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10072855"><a href="/gui2/?type=authors&mode=browse&sel=10072855" target="_blank">Bartha Áron (<span class="authorship-author-name">Bartha Áron</span> <span class="authorAux-mtmt"> Onkológia Bioinformatika Orvosi tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/II. Department of Pediatrics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/II. Department of Pediatrics; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Enzymology">EI</span>/Enzim_417; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31898972" target="_blank">TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">5</span> <span class="page"> Paper 2622. 12 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms22052622" target="_blank" href="https://doi.org/10.3390/ijms22052622"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000628278400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000628278400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85102005778" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85102005778"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33807717" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33807717&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 873</span> | Independent citation: 854 | Self citation: 19 | Unknown citation: 0 | Number of citations in WoS: 842 | Number of citations in Scopus:&nbsp;690 | WoS/Scopus assigned:&nbsp;873 | Number of citations with DOI:&nbsp;862 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31898972&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31898972</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Magyar-koreai kutatás-fejlesztési együttműködési pályázat(2018-2.1.17-TÉT-KR-00001) Funder: NKFIH, (2018-1.3.1-VKE-2018-00032), Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Funder: Ministry for Innovation and Technology </div> <div class="lastModified">Last Modified: 2024.12.06. 18:57 Róbert Milánkovics (PTE ÁOK admin 4) </div> </div></div>