https://m2.mtmt.hu/ hun 2026-09-21 15:35 JournalArticle 31885542 VALIDATED true Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Doctoral School of Multidisciplinary Medical Sciences, University of Szeged, Dugonics square 13, Szeged, 6720, Hungary Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, 44801, Germany Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary School of Ph.D. Studies, Semmelweis University, Budapest, 1085, Hungary Aktogen Hungary Ltd., Kecskemét, 6000, Hungary Cluster of Excellence RESOLV, Bochum, Germany Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, 40225, Germany Export Date: 23 August 2025; Cited By: 3; Correspondence Address: E. Welker; Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary; email: welker.ervin@brc.hu; J. Tatzelt; Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, 44801, Germany; email: Joerg.Tatzelt@ruhr-uni-bochum.de 0 false 2026-08-04T08:24:22.325+0000 2025-08-25T14:43:05.782+0000 2021-02-22T10:35:20.969+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 2025-08-25T14:43:59.873+0000 2025-08-25T14:43:59.873+0000 2022-02-23T12:45:49.610+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin Patkósné Hanesz Andrea (SZBK-4-es admin) true 10045852 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Sangeetham, S.B. true true /api/journal/10019966 REVIEWED SCIENTIFIC REPORTS 2045-2322 true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 11 1 3116 3116 13 2021 Scrapie prion, PrPSc, formation is the central event of all types of transmissible spongiform encephalopathies (TSEs), while the pathway with possible intermediates and their mechanism of formation from the normal isoform of prion (PrP), remains not fully understood. Recently, the G127V variant of the human PrP is reported to render the protein refractory to transmission of TSEs, via a yet unknown mechanism. Molecular dynamics studies suggested that this mutation interferes with the formation of PrP dimers. Here we analyze the dimerization of 127G and 127VPrP, in both in vitro and a mammalian cell culture system. Our results show that while molecular dynamics may capture the features affecting dimerization in vitro, G127V inhibiting dimer formation of PrP, these are not evidenced in a more complex cellular system. © 2021, The Author(s). Funding 2008239 /api/funding/2008239 (K128188) false true Funding 2008240 /api/funding/2008240 (K134968) false true Funding 2008241 /api/funding/2008241 (2018-1.1.1-MKI-2018-00124) false true Funding 2008242 /api/funding/2008242 (VEKOP-2.1.7-15-2016-00402) false true true 2021 true true true false false false GOLD 2026-08-04 true https://doi.org/10.1038/s41598-021-82647-w 8 0 8 8 0 8 8 8 5 8 8 8 8 8 0 0 8 8 8 8 0 2 2 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 3 3 3 3 2024 0 0 0 0 0 2025 0 2 2 2 2 2026 0 2 2 2 2 D1 A nemzetközi false 10024982 false false false 2021-02-21T10:38:14.050+0000 Biokémiai Intézet (HRN SZBK); Doktori Iskola (SE); Enzimológiai Intézet (TTK); Multidiszciplináris Orvostudományok Doktori Iskola (SZTE / DI) 4 27 4 6 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 95563258 /api/authorship/95563258 Sangeetham, S.B. [Sangeetham, Sudheer Babu (Biokémia neurobio...), szerző] Biokémiai Intézet (HRN SZBK); Multidiszciplináris Orvostudományok Doktori Iskola (SZTE / DI) 1 0.16666667 true false false Author 10064825 /api/author/10064825 Sangeetham Sudheer Babu (Biokémia neurobiológia) Sangeetham Sudheer Babu true 10064825 true Sangeetham S.B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95563259 /api/authorship/95563259 Engelke, A.D.* 2 0.16666667 true false false Engelke A.D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95563260 /api/authorship/95563260 Fodor, E. [Ayaydin-Fodor, Elfrieda (biokémia), szerző] Biokémiai Intézet (HRN SZBK) 3 0.16666667 false false false Author 10024982 /api/author/10024982 Ayaydin-Fodor Elfrieda (biokémia) Ayaydin-Fodor Elfrieda true 10024982 true Fodor E. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95563261 /api/authorship/95563261 Krausz, S.L. [Krausz, Sarah (géntechnológia), szerző] Doktori Iskola (SE) 4 0.16666667 false false false Author 10061281 /api/author/10061281 Krausz Sarah (géntechnológia) Krausz Sarah true 10061281 true Krausz S.L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95563262 /api/authorship/95563262 Tatzelt, J.** ✉ 5 0.16666667 false true true Tatzelt J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 95563263 /api/authorship/95563263 Welker, E. ✉ [Welker, Ervin (Fehérje feltekeredés), szerző] Biokémiai Intézet (HRN SZBK); Enzimológiai Intézet (TTK) 6 0.16666667 false true true Author 10001345 /api/author/10001345 Welker Ervin (Fehérje feltekeredés) Welker Ervin true 10001345 true Welker E. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18464199 /api/publicationidentifier/18464199 DOI: 10.1038/s41598-021-82647-w PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-021-82647-w https://doi.org/10.1038/s41598-021-82647-w false true PublicationIdentifier 18581913 /api/publicationidentifier/18581913 WoS: 000618049600074 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000618049600074 https://www.webofscience.com/wos/woscc/full-record/000618049600074 true true PublicationIdentifier 20547107 /api/publicationidentifier/20547107 REAL: 137536 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true 137536 https://real.mtak.hu/137536 false true PublicationIdentifier 18464198 /api/publicationidentifier/18464198 Scopus: 85100498836 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85100498836 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85100498836 false true PublicationIdentifier 18581919 /api/publicationidentifier/18581919 PubMed: 33542378 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33542378 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33542378&dopt=Abstract true true MtaRating 519359 /api/mtarating/519359 IX. 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(2021) SCIENTIFIC REPORTS 2045-2322 11 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10064825"><a href="/gui2/?type=authors&mode=browse&sel=10064825" target="_blank">Sangeetham S.B. (<span class="authorship-author-name">Sangeetham Sudheer Babu</span> <span class="authorAux-mtmt"> Biokémia neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Multidiszciplináris Orvostudományok Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Engelke A.D.^* </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024982"><a href="/gui2/?type=authors&mode=browse&sel=10024982" target="_blank">Fodor E. (<span class="authorship-author-name">Ayaydin-Fodor Elfrieda</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061281"><a href="/gui2/?type=authors&mode=browse&sel=10061281" target="_blank">Krausz S.L. (<span class="authorship-author-name">Krausz Sarah</span> <span class="authorAux-mtmt"> géntechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tatzelt J.^** ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001345"><a href="/gui2/?type=authors&mode=browse&sel=10001345" target="_blank">Welker E. ✉ (<span class="authorship-author-name">Welker Ervin</span> <span class="authorAux-mtmt"> Fehérje feltekeredés</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31885542" target="_blank">The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">1</span> <span class="page"> Paper 3116. 13 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-021-82647-w" target="_blank" href="https://doi.org/10.1038/s41598-021-82647-w"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000618049600074" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000618049600074"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="137536" target="_blank" href="https://real.mtak.hu/137536"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85100498836" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85100498836"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33542378" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33542378&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 8 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;5 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31885542&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31885542</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (K128188), (K134968), (2018-1.1.1-MKI-2018-00124), (VEKOP-2.1.7-15-2016-00402) </div> <div class="lastModified">Utolsó módosítás: 2025.08.25. 16:43 Tóth-Lipták Péter (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Doctoral School of Multidisciplinary Medical Sciences, University of Szeged, Dugonics square 13, Szeged, 6720, Hungary Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, 44801, Germany ...</pre> </div></div>