https://m2.mtmt.hu/ eng 2026-10-23 04:51 JournalArticle 31854303 VALIDATED true Drs. Megyesfalvi and Tallosy contributed equally to this work 0 false 2026-10-22T07:08:31.473+0000 2024-09-30T01:34:09.991+0000 2021-02-08T17:21:57.397+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2026-01-23T07:29:20.845+0000 2026-01-23T07:29:20.845+0000 2022-08-11T07:37:51.901+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2023-10-04T07:54:51.165+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Megyesfalvi, Zsolt The landscape of small cell lung cancer metastases: Organ specificity and timing true true /api/journal/10023056 REVIEWED true false 10023056 false 10023056 true 1759-7706 1759-7714 Journal FOREIGN 12 6 914 923 914 10 2021 Early metastasis is a hallmark of small cell lung cancer (SCLC). However, the mechanisms and resulting patterns of SCLC dissemination are unclear. Our aim was thus to investigate the organ specificity and timing of blood-borne metastases in a comprehensive large cohort of SCLC patients.In this retrospective non-interventional cross-sectional study of 1009 Caucasian SCLC patients, we investigated the correlation between the distinct locations of the primary tumor and metastatic sites.The onset of bone (p < 0.001), brain (p < 0.001), and pericardial (p = 0.02) metastases were late events, whereas adrenal gland (p = 0.005) and liver (p < 0.001) metastases occurred earlier. No significant difference was found in the distribution of early versus late metastases when comparing central and peripheral primary tumors. Patients with bone metastases had a higher than expected likelihood of having liver metastases, while brain metastases tended to appear together with adrenal gland metastases. Pleural and both lung and pericardial metastases also tended to co-metastasize together more frequently than expected if metastatic events occurred independently. Notably, patients with central primary tumors had decreased median overall survival (OS) compared to those with peripheral tumors, although this tendency does not appear to be significant (p = 0.072).Our results are suggestive for particular site- and sequence-specific metastasis patterns in human SCLC. SCLC bone metastases tend to appear together with liver metastases, while brain metastases occur together with adrenal gland metastases. Better understanding of metastasis distribution patterns might help to improve the diagnosis and therapeutic decision-making in SCLC patients. Funding 1999887 /api/funding/1999887 false true Funding 2007459 /api/funding/2007459 false true Funding 2007460 /api/funding/2007460 false true Funding 2007461 /api/funding/2007461 false true Funding 2007462 /api/funding/2007462 false true Funding 2007463 /api/funding/2007463 false true Funding 2007464 /api/funding/2007464 false true Funding 2007465 /api/funding/2007465 false true Funding 2009075 /api/funding/2009075 false true true true 2021 true true true false true false GOLD 2026-10-22 true https://doi.org/10.1111/1759-7714.13854 42 0 42 35 7 42 42 39 36 41 41 34 34 35 7 0 42 35 42 35 0 2 2 Folyóiratcikk Journal Article 24 41 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 1 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 2 1 2 1 2022 0 3 3 3 3 2023 0 7 6 7 6 2024 0 12 10 12 10 2025 0 12 9 12 9 2026 0 6 6 6 6 Q2 false 10071898,10037177 false false false 2021-05-09T16:22:44.396+0000 II. Sz. Patológiai Intézet (SE / AOK / I); Komplex Rendszerek Fizikája Tanszék (ELTE / TTK / FizCsill_I); MTA-SE-NAP B Agymetasztázis Kutatócsoport (SE / AOK / I / IISZPI); Mellkassebészeti Klinika (SE / AOK / K); Országos Korányi Pulmonológiai Intézet; Országos Onkológiai Intézet 9 41 6 13 0 true 10073918 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 95378098 /api/authorship/95378098 1 0.077 true false true Author 10071898 /api/author/10071898 Megyesfalvi Zsolt true true Megyesfalvi Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95378099 /api/authorship/95378099 2 0.07692308 true false Author 10071771 /api/author/10071771 Tallósy Bernadett true true Tallosy Bernadett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95378100 /api/authorship/95378100 3 0.077 false false false Author 10060440 /api/author/10060440 Pipek Orsolya Anna true 10060440 true Pipek 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AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95378106 /api/authorship/95378106 9 0.07692308 false false false Author 10034324 /api/author/10034324 Rényi-Vámos Ferenc István true 10034324 true Renyi-Vamos Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95378107 /api/authorship/95378107 10 0.07692308 false false false Author 10037177 /api/author/10037177 László Viktória true 10037177 true Laszlo Viktoria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95378108 /api/authorship/95378108 11 0.07692308 false false false Author 10024371 /api/author/10024371 Rezeli Melinda true 10024371 true Rezeli Melinda true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95378109 /api/authorship/95378109 12 0.077 false false false Author 10003072 /api/author/10003072 Moldvay Judit true 10003072 true Moldvay Judit true 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33533174 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33533174&dopt=Abstract false true Keyword 1168 /api/keyword/1168 true 1168 true Keyword 1227880 /api/keyword/1227880 true 1227880 true Keyword 2269420 /api/keyword/2269420 true true SjrRating 11225792 /api/sjrrating/11225792 913 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 DIRECT true true /api/publication/31854303 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071898"><a href="/gui2/?type=authors&mode=browse&sel=10071898" target="_blank">Megyesfalvi Zsolt ✉ (<span class="authorship-author-name">Megyesfalvi Zsolt</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery; Koranyi National Institute for Pulmonology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071771"><a href="/gui2/?type=authors&mode=browse&sel=10071771" target="_blank">Tallosy Bernadett<sup>*</sup> (<span class="authorship-author-name">Tallósy Bernadett</span> <span class="authorAux-mtmt"> mellkassebészet</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060440"><a href="/gui2/?type=authors&mode=browse&sel=10060440" target="_blank">Pipek Orsolya (<span class="authorship-author-name">Pipek Orsolya Anna</span> <span class="authorAux-mtmt"> bioinformatika, big data, onkológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Physics">Inst_Phys</span>/Department of Physics of Complex Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023823"><a href="/gui2/?type=authors&mode=browse&sel=10023823" target="_blank">Fillinger Janos (<span class="authorship-author-name">Fillinger János</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lang Christian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Klikovits Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schwendenwein Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoda Mir Alireza </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034324"><a href="/gui2/?type=authors&mode=browse&sel=10034324" target="_blank">Renyi-Vamos Ferenc (<span class="authorship-author-name">Rényi-Vámos Ferenc István</span> <span class="authorAux-mtmt"> Mellkassebész</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037177"><a href="/gui2/?type=authors&mode=browse&sel=10037177" target="_blank">Laszlo Viktoria (<span class="authorship-author-name">László Viktória</span> <span class="authorAux-mtmt"> tumorbiologia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024371"><a href="/gui2/?type=authors&mode=browse&sel=10024371" target="_blank">Rezeli Melinda (<span class="authorship-author-name">Rezeli Melinda</span> <span class="authorAux-mtmt"> mass spectrometry</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003072"><a href="/gui2/?type=authors&mode=browse&sel=10003072" target="_blank">Moldvay Judit (<span class="authorship-author-name">Moldvay Judit</span> <span class="authorAux-mtmt"> Tüdõgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="II. Department of Pathology">IIDP</span>/MTA-SE-NAP B Brain Metastasis Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000046"><a href="/gui2/?type=authors&mode=browse&sel=10000046" target="_blank">Dome Balazs ✉ (<span class="authorship-author-name">Döme Balázs</span> <span class="authorAux-mtmt"> Tumor indukált angiogenezis</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31854303" target="_blank">The landscape of small cell lung cancer metastases: Organ specificity and timing</a></div> <div> <span class="journal-title">THORACIC CANCER</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1759-7706">1759-7706</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1759-7714">1759-7714</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">6</span> <span class="page"> pp 914-923 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1111/1759-7714.13854" target="_blank" href="https://doi.org/10.1111/1759-7714.13854"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000614035400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000614035400001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="110761" target="_blank" href="https://edit.elte.hu/handle/10831/110761"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85100306556" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85100306556"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33533174" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33533174&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Pulmonary and Respiratory Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 42</span> | Independent citation: 35 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 39 | Number of citations in Scopus:&nbsp;36 | WoS/Scopus assigned:&nbsp;41 | Number of citations with DOI:&nbsp;42 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31854303&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31854303</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, (K129065), (KH130356), (KNN121510), (NAP2-2017-1.2.1-NKP-0002), (NVKP_16-1-2016-0004) Funder: NRDIO, (ÚNKP-19-4), (ÚNKP-20-3), (Open access funding of Semmelweis University) </div> <div class="lastModified">Last Modified: 2024.09.30. 03:34 József Áts (ÁtsJ adm2-3, admin) </div> <div class="lockedBy">Centrally managed 2023.10.04. 09:54 Marcell Kovács (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Drs. Megyesfalvi and Tallosy contributed equally to this work</pre> </div></div>