https://m2.mtmt.hu/ eng 2026-05-08 16:56 JournalArticle 31853828 APPROVED true Departments of Medicine and Clinical Science and, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan Departments of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Cited By :38 Export Date: 8 February 2021 CODEN: JVREE Correspondence Address: Kuroda, J.; Departments of Medicine and Clinical Science and, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Japan Chemicals/CAS: angiotensin II, 11128-99-7; reduced nicotinamide adenine dinucleotide phosphate, 53-57-6; superoxide, 11062-77-4; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; Angiotensin II; Enzyme Inhibitors; NADPH Oxidase; NOX4 protein, human; Nox4 protein, mouse; Receptors, Angiotensin; Superoxides Funding details: Japan Society for the Promotion of Science, JSPS, 25461134, 26462163, 26461145 0 false 2024-08-30T14:12:01.639+0000 2021-02-08T14:31:53.395+0000 2021-02-08T13:57:55.722+0000 true 10001362 Várnai Péter /api/author/10001362 Author Péter Várnai (Sejtélettan) true 10001362 2024-08-30T14:11:00.225+0000 false false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Kuroda, J. true true /api/journal/2931 REVIEWED JOURNAL OF VASCULAR RESEARCH 1018-1172 1423-0135 true false 2931 false 2931 true 1018-1172 1423-0135 Journal FOREIGN 51 6 429 438 429 10 2014 Background: Pericytes are multifunctional cells surrounding capillaries and postcapillary venules. In brain microvasculature, pericytes play a pivotal role under physiological and pathological conditions by producing reactive oxygen species (ROS). The aims of this study were to elucidate the source of ROS and its regulation in human brain pericytes. Methods: The expression of Nox enzymes in the cells was evaluated using RT-PCR and western blot. Superoxide production was determined by superoxide dismutase-inhibitable chemiluminescence. Silencing of Nox4 was performed using RNAi, and cell proliferation was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. Results: Nox4 was predominant among the Nox family in human brain pericytes. Membrane fractions of cells produced superoxide in the presence of NAD(P)H. Superoxide production was almost abolished with diphenileneiodonium, a Nox inhibitor; however, inhibitors of other possible superoxide-producing enzymes had no effect on NAD(P)H-dependent superoxide production. Pericytes expressed angiotensin II (Ang II) receptors, and Ang II upregulated Nox4 expression. Hypoxic conditions also increased the Nox4 expression. Silencing of Nox4 significantly reduced ROS production and attenuated cell proliferation. Conclusion: Our study showed that Nox4 is a major superoxide-producing enzyme and that its expression is regulated by Ang II and hypoxic stress in human brain pericytes. In addition, Nox4 may promote cell growth. © 2015 S. Karger AG, Basel. 2021 true true true false false NONE 2024-08-30 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q1 false false false false 2021-05-09T13:31:53.166+0000 2 10 0 8 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 95376374 /api/authorship/95376374 Kuroda, J. ✉ 1 0.0 true false true Kuroda J. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95376375 /api/authorship/95376375 Ago, T. 2 0.0 false false false Ago T. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95376376 /api/authorship/95376376 Nishimura, A. 3 0.0 false false false Nishimura A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95376377 /api/authorship/95376377 Nakamura, K. 4 0.0 false false false Nakamura K. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95376378 /api/authorship/95376378 Matsuo, R. 5 0.0 false false false Matsuo R. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95376379 /api/authorship/95376379 Wakisaka, Y. 6 0.0 false false false Wakisaka Y. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95376380 /api/authorship/95376380 Kamouchi, M. 7 0.0 false false false Kamouchi M. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95376381 /api/authorship/95376381 Kitazono, T. 8 0.0 false true false Kitazono T. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 18381010 /api/publicationidentifier/18381010 DOI: 10.1159/000369930 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 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(2014) JOURNAL OF VASCULAR RESEARCH 1018-1172 1423-0135 51 6 429-438<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Kuroda J. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ago T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nishimura A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nakamura K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matsuo R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wakisaka Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kamouchi M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kitazono T. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31853828" target="_blank">Nox4 is a major source of superoxide production in human brain pericytes</a></div> <div> <span class="journal-title">JOURNAL OF VASCULAR RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1018-1172">1018-1172</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1423-0135">1423-0135</a>)</span>: <span class="journal-volume">51</span> <span class="journal-issue">6</span> <span class="page"> pp 429-438 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1159/000369930" target="_blank" href="https://doi.org/10.1159/000369930"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000350393400003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000350393400003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84924250456" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84924250456"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31853828&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31853828</span> | <span class="status-data status-APPROVED"> Published </span> Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2021.02.08. 15:31 Kinga Sonnevend (SE_AOK_Élettan_Admin5_SK, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Departments of Medicine and Clinical Science and, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan Departments of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Cited By :38 Export Date: 8 February 2021 ...</pre> </div></div>