https://m2.mtmt.hu/ eng 2026-10-25 10:39 JournalArticle 31852761 ADMIN_APPROVED true 0 false 2026-10-21T02:35:59.975+0000 2024-09-12T09:43:28.064+0000 2021-02-08T08:11:17.838+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2025-10-28T13:01:55.944+0000 2025-10-28T13:01:55.944+0000 2024-09-12T09:43:28.345+0000 true 10003133 Boros Annamária /api/admin/10003133 Admin true 10003133 Admin 10003133 /api/admin/10003133 Boros Annamária true 10003133 true 2024-09-13T11:56:08.998+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Birtalan, Eszter Efficient training of mice on the 5-choice serial reaction time task in an automated rodent training system. true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 10 1 22362 22362 18 2020 Experiments aiming to understand sensory-motor systems, cognition and behavior necessitate training animals to perform complex tasks. Traditional training protocols require lab personnel to move the animals between home cages and training chambers, to start and end training sessions, and in some cases, to hand-control each training trial. Human labor not only limits the amount of training per day, but also introduces several sources of variability and may increase animal stress. Here we present an automated training system for the 5-choice serial reaction time task (5CSRTT), a classic rodent task often used to test sensory detection, sustained attention and impulsivity. We found that full automation without human intervention allowed rapid, cost-efficient training, and decreased stress as measured by corticosterone levels. Training breaks introduced only a transient drop in performance, and mice readily generalized across training systems when transferred from automated to manual protocols. We further validated our automated training system with wireless optogenetics and pharmacology experiments, expanding the breadth of experimental needs our system may fulfill. Our automated 5CSRTT system can serve as a prototype for fully automated behavioral training, with methods and principles transferrable to a range of rodent tasks. true true 2021 true true true false true false GOLD 2026-10-21 true https://doi.org/10.1038/s41598-020-79290-2 15 0 15 14 1 15 15 15 13 15 15 14 14 14 1 0 15 14 15 14 0 4 4 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 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Author 10048338 /api/author/10048338 Balázsfi Diána true 10048338 true Balázsfi Diána true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 95372230 /api/authorship/95372230 5 0.2 false true true Author 220 /api/author/220 Hangya Balázs true 220 true Hangya Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 18378562 /api/publicationidentifier/18378562 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-020-79290-2 https://doi.org/10.1038/s41598-020-79290-2 false true PublicationIdentifier 18378563 /api/publicationidentifier/18378563 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33349672 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33349672&dopt=Abstract false true MtaRating 519359 /api/mtarating/519359 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi true true SjrRating 10859083 /api/sjrrating/10859083 10 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/31852761 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10087696"><a href="/gui2/?type=authors&mode=browse&sel=10087696" target="_blank">Birtalan Eszter (<span class="authorship-author-name">Birtalan Eszter</span> <span class="authorAux-mtmt"> informatika tudományág</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bánhidi Anita </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sanders Joshua I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048338"><a href="/gui2/?type=authors&mode=browse&sel=10048338" target="_blank">Balázsfi Diána ✉ (<span class="authorship-author-name">Balázsfi Diána</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Lendület Laboratory of System-Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="220"><a href="/gui2/?type=authors&mode=browse&sel=220" target="_blank">Hangya Balázs ✉ (<span class="authorship-author-name">Hangya Balázs</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Lendület Laboratory of System-Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31852761" target="_blank">Efficient training of mice on the 5-choice serial reaction time task in an automated rodent training system.</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">1</span> <span class="page"> Paper 22362. 18 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-020-79290-2" target="_blank" href="https://doi.org/10.1038/s41598-020-79290-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000603059300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000603059300001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="122438" target="_blank" href="https://real.mtak.hu/122438"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85097958565" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85097958565"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33349672" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33349672&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 15</span> | Independent citation: 14 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 15 | Number of citations in Scopus:&nbsp;13 | WoS/Scopus assigned:&nbsp;15 | Number of citations with DOI:&nbsp;15 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31852761&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31852761</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2024.09.12. 11:43 Annamária Boros (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.09.13. 13:56 Annamária Boros (MTMT Központi admin) </div> </div></div>