{ "labelLang" : "hun", "responseDate" : "2024-03-28 12:31", "content" : { "otype" : "JournalArticle", "mtid" : 3185080, "status" : "VALIDATED", "published" : true, "comment" : "Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece \n Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, United States \n Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, United States \n Computer Science Department, Purdue University, West Lafayette, IN, United States \n Vadaskert Clinic for Child and Adolescent Psychiatry, Budapest, Hungary \n Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy \n Department of Child Psychiatry, Medical University of Warsaw, Warsaw, Poland \n Child and Adolescent Psychiatry Clinic, Sismanoglio General Hospital of Attica, Athens, Greece \n Molecular Biology and Pathobiochemistry, Institute of Medical Chemistry, Semmelweis University, Budapest, Hungary \n Tourette Syndrome Genetics, Southern and Eastern Europe Initiative (TSGeneSEE Consortium)ON, Canada \n Department of Psychiatry, University of Toronto, Toronto, ON, Canada \n Genetics and Development Division, Krembil Research Institute, University Health Network, Toronto, ON, Canada \n Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada \n Laboratory of General Biology, Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece \n Cited By :15 \n Export Date: 23 August 2022 \n Correspondence Address: Heiman, G.A.; Department of Genetics, United States; email: heiman@dls.rutgers.edu \n Chemicals/CAS: citalopram, 59729-33-8 \n Funding details: MS40024-01 \n Funding details: National Institute of Mental Health, NIMH, R01MH092293, U24MH068457 \n Funding details: Seventh Framework Programme, FP7, 316978 \n Funding details: European Cooperation in Science and Technology, COST, FP7-PEOPLE-2012-ITN \n Funding details: Semmelweis Egyetem \n Funding details: Ontario Mental Health Foundation, OMHF \n Funding details: Magyar Tudományos Akadémia, MTA, BO/00987/16/5 \n Funding text 1: We are indebted to the TS individuals and their families for accepting to participate in the studies of the genetic basis of TS. This study was made possible thanks to the collaborative efforts of Tourette Syndrome Genetics-Southern and Eastern Europe Initiative (TSGeneSEE) and COST Action BM905: European Network for the Study of GTS (EUNETGTS). This project was financed by FP7-PEOPLE-2012-ITN, project: TS-EUROTRAIN, grant number 316978, and grants from the National Institute of Mental Health [R01MH092293; U24MH068457] and the Human Genetics Institute of New Jersey. The collection of Canadian families for this study was supported by grants from The Tourette Syndrome Association of America, N.I.H. grant MS40024-01, the Ontario Mental Health Foundation, and The Tourette Syndrome Foundation of Canada. CB was supported by the Merit-prize scholarship of Semmelweis University and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00987/16/5.", "unhandledTickets" : 0, "oldTimestamp" : "2018-06-22T11:07:10.000+0000", "deleted" : false, "oldId" : 3185080, "lastRefresh" : "2024-02-18T17:26:03.221+0000", "lastModified" : "2022-01-28T08:26:05.474+0000", "created" : "2017-02-15T11:54:12.000+0000", "creator" : { "otype" : "Author", "mtid" : 10023664, "link" : "/api/author/10023664", "label" : "Barta Csaba (pszichogenetika)", "familyName" : "Barta", "givenName" : "Csaba", "published" : true, "oldId" : 10023664, "snippet" : true }, "lastDuplumSearch" : "2023-01-31T12:16:45.248+0000", "adminApproved" : "2018-06-22T11:07:10.000+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10026589, "link" : "/api/admin/10026589", "label" : "Tichy Rita (SE_KK_Admin5_TR, admin)", "familyName" : "Tichy", "givenName" : "Rita", "published" : true, "oldId" : 10026589, "snippet" : true }, "validated" : "2022-01-28T08:26:05.492+0000", "validator" : { "otype" : "Admin", "mtid" : 10026589, "link" : "/api/admin/10026589", "label" : "Tichy Rita (SE_KK_Admin5_TR, admin)", "familyName" : "Tichy", "givenName" : "Rita", "published" : true, "oldId" : 10026589, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Alexander, J", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 8849891, "link" : "/api/authorship/8849891", "label" : "Alexander, J", "listPosition" : 1, "share" : 0.04347826, "first" : true, "last" : false, "familyName" : "Alexander", "givenName" : "J", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615083, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849892, "link" : "/api/authorship/8849892", "label" : "Potamianou, H*", "listPosition" : 2, "share" : 0.043, "first" : true, "last" : false, "familyName" : "Potamianou", "givenName" : "H", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615082, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849893, "link" : "/api/authorship/8849893", "label" : "Xing, JC", "listPosition" : 3, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Xing", "givenName" : "JC", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615081, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849894, "link" : "/api/authorship/8849894", "label" : "Deng, L", "listPosition" : 4, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Deng", "givenName" : "L", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615080, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849895, "link" : "/api/authorship/8849895", "label" : "Karagiannidis, I", "listPosition" : 5, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Karagiannidis", "givenName" : "I", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615079, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849896, "link" : "/api/authorship/8849896", "label" : "Tsetsos, F", "listPosition" : 6, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Tsetsos", "givenName" : "F", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615078, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849897, "link" : "/api/authorship/8849897", "label" : "Drineas, P", "listPosition" : 7, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Drineas", "givenName" : "P", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615077, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849898, "link" : "/api/authorship/8849898", "label" : "Tarnok, Z [Tárnok, Zsanett (Gyermek- és Ifjús...), szerző]", "listPosition" : 8, "share" : 0.04347826, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10064577, "link" : "/api/author/10064577", "label" : "Tárnok Zsanett (Gyermek- és Ifjúságpszichológia)", "familyName" : "Tárnok", "givenName" : "Zsanett", "published" : false, "oldId" : 10064577, "snippet" : true }, "familyName" : "Tarnok", "givenName" : "Z", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615076, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849899, "link" : "/api/authorship/8849899", "label" : "Rizzo, R", "listPosition" : 9, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Rizzo", "givenName" : "R", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615075, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849900, "link" : "/api/authorship/8849900", "label" : "Wolanczyk, T", "listPosition" : 10, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Wolanczyk", "givenName" : "T", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615074, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849901, "link" : "/api/authorship/8849901", "label" : "Farkas, L", "listPosition" : 11, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Farkas", "givenName" : "L", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615073, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849902, "link" : "/api/authorship/8849902", "label" : "Nagy, P [Nagy, Péter (gyermek- és ifjús...), szerző]", "listPosition" : 12, "share" : 0.04347826, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10066513, "link" : "/api/author/10066513", "label" : "Nagy Péter (gyermek- és ifjúságpszichiátria)", "familyName" : "Nagy", "givenName" : "Péter", "published" : true, "snippet" : true }, "familyName" : "Nagy", "givenName" : "P", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615072, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849903, "link" : "/api/authorship/8849903", "label" : "Szymanska, U", "listPosition" : 13, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Szymanska", "givenName" : "U", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615071, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849904, "link" : "/api/authorship/8849904", "label" : "Androutsos, C", "listPosition" : 14, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Androutsos", "givenName" : "C", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615070, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849905, "link" : "/api/authorship/8849905", "label" : "Tsironi, V", "listPosition" : 15, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Tsironi", "givenName" : "V", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615069, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849906, "link" : "/api/authorship/8849906", "label" : "Koumoulas, A", "listPosition" : 16, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Koumoulas", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615068, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849907, "link" : "/api/authorship/8849907", "label" : "Barta, C [Barta, Csaba (pszichogenetika), szerző] Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I)", "listPosition" : 17, "share" : 0.04347826, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10023664, "link" : "/api/author/10023664", "label" : "Barta Csaba (pszichogenetika)", "familyName" : "Barta", "givenName" : "Csaba", "published" : true, "oldId" : 10023664, "snippet" : true }, "familyName" : "Barta", "givenName" : "C", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615067, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849908, "link" : "/api/authorship/8849908", "label" : "Sandor, P", "listPosition" : 18, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Sandor", "givenName" : "P", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615066, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849909, "link" : "/api/authorship/8849909", "label" : "Barr, CL", "listPosition" : 19, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Barr", "givenName" : "CL", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615065, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849910, "link" : "/api/authorship/8849910", "label" : "Tischfield, J", "listPosition" : 20, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Tischfield", "givenName" : "J", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615064, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849911, "link" : "/api/authorship/8849911", "label" : "Paschou, P", "listPosition" : 21, "share" : 0.04347826, "first" : false, "last" : false, "familyName" : "Paschou", "givenName" : "P", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615063, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849912, "link" : "/api/authorship/8849912", "label" : "Heiman, GA ✉", "listPosition" : 22, "share" : 0.043, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Heiman", "givenName" : "GA", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615062, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8849913, "link" : "/api/authorship/8849913", "label" : "Georgitsi, M ✉", "listPosition" : 23, "share" : 0.043, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Georgitsi", "givenName" : "M", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25615061, "snippet" : true } ], "title" : "Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 1175498, "link" : "/api/publicationidentifier/1175498", "label" : "DOI: 10.3389/fnins.2016.00428", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaType" : "GOLD", "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "10.3389/fnins.2016.00428", "realUrl" : "https://doi.org/10.3389/fnins.2016.00428", "published" : false, "oldId" : 1545014, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1175500, "link" : "/api/publicationidentifier/1175500", "label" : "SE Repozitórium: 4848", "source" : { "otype" : "SwordSource", "mtid" : 84, "link" : "/api/publicationsource/84", "label" : "SE Repozitórium", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "SE Repozitórium", "nameEng" : "SE Repozitórium", "linkPattern" : "https://repo.lib.semmelweis.hu/handle/123456789/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 84, "snippet" : true }, "oaType" : "GREEN", "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "4848", "realUrl" : "https://repo.lib.semmelweis.hu/handle/123456789/4848", "published" : false, "oldId" : 1724775, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1175496, "link" : "/api/publicationidentifier/1175496", "label" : "WoS: 000383764300001", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "000383764300001", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000383764300001", "published" : false, "oldId" : 1545013, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1175497, "link" : "/api/publicationidentifier/1175497", "label" : "Scopus: 84992016847", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "84992016847", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84992016847", "published" : false, "oldId" : 1545017, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1175499, "link" : "/api/publicationidentifier/1175499", "label" : "PubMed: 27708560", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "27708560", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27708560&dopt=Abstract", "published" : false, "oldId" : 1545012, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 39990, "link" : "/api/journal/39990", "label" : "FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X", "pIssn" : "1662-4548", "eIssn" : "1662-453X", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 39990, "snippet" : true }, "volume" : "10", "internalId" : "428", "firstPageOrInternalIdForSort" : "428", "pageLength" : 7, "publishedYear" : 2016, "abstractText" : "Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9, and SLC6A4) in an effort to identify possibly causal variants using a targeted re-sequencing approach by next generation sequencing technology. Identification of possible disease causing variants under different modes of inheritance was performed using the algorithms implemented in VAAST. We prioritized variants using Variant ranker and validated five rare variants via Sanger sequencing in HDC and SLITRK1, all of which are predicted to be deleterious. Intriguingly, one of the identified variants is in linkage disequilibrium with a variant that is included among the top hits of a genome-wide association study for response to citalopram treatment, an antidepressant drug with off-label use also in obsessive compulsive disorder. Our findings provide additional evidence for the implication of these two genes in TS susceptibility and the possible role of these proteins in the pathobiology of TS should be revisited.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 82, "link" : "/api/keyword/82", "label" : "HISTAMINE", "published" : true, "oldId" : 82, "snippet" : true }, { "otype" : "Keyword", "mtid" : 217, "link" : "/api/keyword/217", "label" : "MUTATION", "published" : true, "oldId" : 217, "snippet" : true }, { "otype" : "Keyword", "mtid" : 623, "link" : "/api/keyword/623", "label" : "ASSOCIATION", "published" : true, "oldId" : 623, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1115, "link" : "/api/keyword/1115", "label" : "HISTIDINE-DECARBOXYLASE", "published" : true, "oldId" : 1115, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1227, "link" : "/api/keyword/1227", "label" : "OBSESSIVE-COMPULSIVE DISORDER", "published" : true, "oldId" : 1227, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4560, "link" : "/api/keyword/4560", "label" : "genetic susceptibility", "published" : true, "oldId" : 4560, "snippet" : true }, { "otype" : "Keyword", "mtid" : 17445, "link" : "/api/keyword/17445", "label" : "basal ganglia", "published" : true, "oldId" : 17445, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1058849, "link" : "/api/keyword/1058849", "label" : "restless legs syndrome", "published" : true, "oldId" : 1058849, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1066349, "link" : "/api/keyword/1066349", "label" : "slitrk1 gene", "published" : true, "oldId" : 1066349, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1066352, "link" : "/api/keyword/1066352", "label" : "SLITRK1", "published" : true, "oldId" : 1066352, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1159589, "link" : "/api/keyword/1159589", "label" : "HDC", "published" : true, "oldId" : 1159589, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1245551, "link" : "/api/keyword/1245551", "label" : "Rare variants", "published" : true, "oldId" : 1245551, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1268965, "link" : "/api/keyword/1268965", "label" : "Next generation sequencing", "published" : true, "oldId" : 1268965, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1435467, "link" : "/api/keyword/1435467", "label" : "ITALIAN FAMILY", "published" : true, "oldId" : 1435467, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1435468, "link" : "/api/keyword/1435468", "label" : "CHINESE HAN PATIENTS", "published" : true, "oldId" : 1435468, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1435469, "link" : "/api/keyword/1435469", "label" : "TS candidate genes", "published" : true, "oldId" : 1435469, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1435471, "link" : "/api/keyword/1435471", "label" : "targeted re-sequencing", "published" : true, "oldId" : 1435471, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2017, "packet" : "452227", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-18", "oaFree" : true, "oaLink" : "https://doi.org/10.3389/fnins.2016.00428", "oaByAuthor" : { "otype" : "Admin", "mtid" : 10026589, "link" : "/api/admin/10026589", "label" : "Tichy Rita (SE_KK_Admin5_TR, admin)", "familyName" : "Tichy", "givenName" : "Rita", "published" : true, "oldId" : 10026589, "snippet" : true }, "citationCount" : 18, "citationCountUnpublished" : 0, "citationCountWoOther" : 18, "independentCitCountWoOther" : 13, "nationalOriginCitationCount" : 2, "foreignEditionCitationCount" : 18, "doiCitationCount" : 18, "wosCitationCount" : 17, "scopusCitationCount" : 18, "wosScopusCitationCount" : 18, "wosScopusCitationCountWoOther" : 18, "wosScopusIndependentCitationCount" : 13, "wosScopusIndependentCitationCountWoOther" : 13, "independentCitationCount" : 13, "selfCitationCount" : 5, "unhandledCitationCount" : 0, "citingPubCount" : 18, "independentCitingPubCount" : 13, "citingPubCountWoOther" : 18, "independentCitingPubCountWoOther" : 13, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "pubStats" : { "types" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "count" : 18 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "count" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "count" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "count" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "count" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "count" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "count" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "count" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "count" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "count" : 0 } ], "citationTypes" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 } ], "years" : [ { "year" : 2017, "publicationCount" : 0, "citationCount" : 4, "independentCitationCount" : 3, "citingPubCount" : 4, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2018, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 1, "citingPubCount" : 2, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2019, "publicationCount" : 0, "citationCount" : 4, "independentCitationCount" : 4, "citingPubCount" : 4, "independentCitingPubCount" : 4, "oaStats" : null, "oaStats2" : null }, { "year" : 2020, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 1, "citingPubCount" : 2, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2021, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 1, "citingPubCount" : 3, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2022, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2023, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 2, "citingPubCount" : 2, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null } ] }, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10951976, "link" : "/api/sjrrating/10951976", "label" : "sjr:Q1 (2016) Scopus - Neuroscience (miscellaneous) FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X", "listPos" : 33, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2801, "link" : "/api/classificationexternal/2801", "label" : "Scopus - Neuroscience (miscellaneous)", "published" : true, "oldId" : 2801, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2018-06-22T11:07:10.000+0000", "publishDate" : "2017-02-15T11:55:56.000+0000", "directInstitutesForSort" : "Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I)", "ownerAuthorCount" : 3, "ownerInstituteCount" : 11, "directInstituteCount" : 1, "authorCount" : 23, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/3185080", "label" : "Alexander J et al. Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology. (2016) FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X 10", "template" : "