https://m2.mtmt.hu/ eng 2026-09-21 08:46 JournalArticle 31848850 VALIDATED true 0 false 2026-09-20T16:40:27.407+0000 2025-12-05T07:46:06.451+0000 2021-02-04T14:43:08.075+0000 true 10022879 Schweibert István /api/admin/10022879 Admin István Schweibert (PTE ÁOK admin 6) true 10022879 2026-09-20T16:39:05.970+0000 2023-09-02T13:23:43.779+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 Admin 10067876 /api/admin/10067876 Gusztáv Ladányi (MTMT API user, admin) Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Zsófia Orbán (MTMT ellenőrzés, admin) Orbán Zsófia true true 2024-10-17T16:10:53.532+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Horváth, Ádám true true /api/journal/10026753 REVIEWED FRONTIERS IN PHARMACOLOGY 1663-9812 true false 10026753 false 10026753 true 1663-9812 Journal FOREIGN 11 593319 593319 11 2021 Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions. Lipid rafts are liquid-ordered plasma membrane microdomains rich in cholesterol, sphingomyelin and gangliosides. We earlier showed that lipid raft disruption inhibits TRPV1 and TRPA1 functions in primary sensory neuronal cultures. Here we investigated the effects of sphingomyelinase (SMase) cleaving membrane sphingomyelin and myriocin (Myr) prohibiting sphingolipid synthesis in mouse pain models of different mechanisms. SMase (50 mU) or Myr (1 mM) pretreatment significantly decreased TRPV1 activation (capsaicin)-induced nocifensive eye-wiping movements by 37 and 41%, respectively. Intraplantar pretreatment by both compounds significantly diminished TRPV1 stimulation (resiniferatoxin)-evoked thermal allodynia developing mainly by peripheral sensitization. SMase (50 mU) also decreased mechanical hyperalgesia related to both peripheral and central sensitizations. SMase (50 mU) significantly reduced TRPA1 activation (formalin)-induced acute nocifensive behaviors by 64% in the second, neurogenic inflammatory phase. Myr, but not SMase altered the plasma membrane polarity related to the cholesterol composition as shown by fluorescence spectroscopy. These are the first in vivo results showing that sphingolipids play a key role in lipid raft integrity around nociceptive TRP channels, their activation and pain sensation. It is concluded that local SMase administration might open novel perspective for analgesic therapy. Funding 1994880 /api/funding/1994880 (ÚNKP-18-4) false true Funding 1994881 /api/funding/1994881 (17886-4/23018/FEKUTSTRAT) false true Funding 1994882 /api/funding/1994882 (ÚNKP-19-4) false true Funding 1994883 /api/funding/1994883 Hungarian Brain Research Program((2017-1.2.1-NKP-2017-00002) false true Funding 1994884 /api/funding/1994884 GINOP(2.3.2-15-2016-00050) false true Funding 1994885 /api/funding/1994885 Modern orvostudományi diagnosztikus eljárások és terápiák fejlesztése transzlációs megközelítésbe...(EFOP-3.6.2-16-2017-00006) Funder: EFOP false true Funding 1994886 /api/funding/1994886 (EFOP-3.6.2.-16-2017-00008) false true true 2021 true true true false true false GOLD 2026-09-20 true https://doi.org/10.3389/fphar.2020.593319 22 0 21 14 7 22 21 20 20 20 20 14 14 15 7 0 22 15 21 14 0 18 18 Folyóiratcikk Journal Article 24 21 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 2 2 2 2 2022 0 2 1 2 1 2023 0 3 2 3 2 2024 0 7 3 7 3 2025 0 3 2 3 2 2026 0 5 5 5 5 Q1 false 10019144,10037547,10071348,10003159 false false false 2021-02-03T16:56:59.154+0000 Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Kísérleti Fizika Tanszék (PTE / TTK / FI); Molekuláris farmakológia kutatócsoport (PTE / SZKK); Spektroszkópia kutatócsoport (PTE / SZKK); Szentágothai János Kutatóközpont (PTE) 10 36 6 10 0 true 10097590 10067876 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 95338111 /api/authorship/95338111 Horváth, Ádám ✉ [Horváth, Ádám (Fájdalomkutatás), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 1 0.1 true false true Author 10071348 /api/author/10071348 Ádám Horváth (Fájdalomkutatás) Horváth Ádám true true Horváth Ádám true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338112 /api/authorship/95338112 Payrits, Maja [Payrits, Maja (Gyógyszertudomány), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 2 0.1 false false false Author 10039773 /api/author/10039773 Maja Payrits (Gyógyszertudomány) Payrits Maja true 10039773 true Payrits Maja true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338113 /api/authorship/95338113 Steib, Anita [Steib, Anita (Biológia, Állatsz...), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Szentágothai Research Centre (UP) 3 0.1 false false false Author 10037472 /api/author/10037472 Anita Steib (Biológia, Állatszervezettan) Steib Anita true 10037472 true Steib Anita true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338114 /api/authorship/95338114 Kántás, Boglárka [Kántás, Boglárka (Fájdalomkutatás), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 4 0.1 false false false Author 10071349 /api/author/10071349 Boglárka Kántás (Fájdalomkutatás) Kántás Boglárka true true Kántás Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338115 /api/authorship/95338115 Biró-Sütő, Tünde [Biró-Sütő, Tünde (Gyógyszerészet), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 5 0.1 false false false Author 10067039 /api/author/10067039 Tünde Biró-Sütő (Gyógyszerészet) Biró-Sütő Tünde true true Biró-Sütő Tünde true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338116 /api/authorship/95338116 Erostyák, János [Erostyák, János (Fluoreszcencia sp...), author] Spectroscopy Research Group (UP / SZRC); Department of Experimental Physics (UP / FS / IP) 6 0.1 false false false Author 10003159 /api/author/10003159 János Erostyák (Fluoreszcencia spektroszkópia) Erostyák János true 10003159 true Erostyák János true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338117 /api/authorship/95338117 Makkai, Géza [Makkai, Géza (Fizika), author] Department of Experimental Physics (UP / FS / IP) 7 0.1 false false false Author 10016877 /api/author/10016877 Géza Makkai (Fizika) Makkai Géza true 10016877 true Makkai Géza true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338118 /api/authorship/95338118 Sághy, Éva [Sághy, Éva (Gyógyszertudomány...), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I); Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 8 0.1 false false false Author 10037547 /api/author/10037547 Éva Sághy (Gyógyszertudományok, farmakológia) Sághy Éva true 10037547 true Sághy Éva true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338119 /api/authorship/95338119 Helyes, Zsuzsanna [Helyes, Zsuzsanna (Neurofarmakológia), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 9 0.1 false false false Author 10001426 /api/author/10001426 Zsuzsanna Helyes (Neurofarmakológia) Helyes Zsuzsanna true 10001426 true Helyes Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 95338120 /api/authorship/95338120 Szőke, Éva [Szőke, Éva (Fájdalomkutatás), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 10 0.1 false true false Author 10019144 /api/author/10019144 Éva Szőke (Fájdalomkutatás) Szőke Éva true 10019144 true Szőke Éva true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 18370452 /api/publicationidentifier/18370452 DOI: 10.3389/fphar.2020.593319 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fphar.2020.593319 https://doi.org/10.3389/fphar.2020.593319 false true PublicationIdentifier 18496887 /api/publicationidentifier/18496887 WoS: 000616632700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000616632700001 https://www.webofscience.com/wos/woscc/full-record/000616632700001 false true PublicationIdentifier 18488325 /api/publicationidentifier/18488325 Scopus: 85100818388 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85100818388 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85100818388 false true PublicationIdentifier 18447387 /api/publicationidentifier/18447387 PubMed: 33584270 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33584270 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33584270&dopt=Abstract false true Classification 12125 /api/classification/12125 Basic medicine true true Classification 12184 /api/classification/12184 Pharmacology and pharmacy true true Classification 12124 /api/classification/12124 MEDICAL AND HEALTH SCIENCES true true SjrRating 11233073 /api/sjrrating/11233073 sjr:Q1 (2021) Scopus - Pharmacology (medical) FRONTIERS IN PHARMACOLOGY 1663-9812 38 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2736 /api/classificationexternal/2736 Scopus - Pharmacology (medical) true 2736 true Q1 DIRECT true true Reference 3513922 /api/reference/3513922 1. Adinolfi 2013: Anticancer activity of anandamide in human cutaneous melanoma cells, Eur. J. Pharmacol, 718, p. 154, DOI: 10.1016/j.ejphar.2013.08.039 1 10.1016/j.ejphar.2013.08.039 false true Reference 3513923 /api/reference/3513923 2. Aiello 2016: Design and synthesis of new transient receptor potential vanilloid type-1 (TRPV1) channel modulators: identification, molecular modeling analysis, and pharmacological characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl) butanamide, a small molecule endowed with agonist TRPV1 activity and protective effects against oxidative stress, ACS Chem. Neurosci, 7, p. 737, DOI: 10.1021/acschemneuro.5b00333 2 10.1021/acschemneuro.5b00333 false true Reference 3513924 /api/reference/3513924 3. Akopian 2008: Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation, J. Neurosci, 28, p. 1064, DOI: 10.1523/JNEUROSCI.1565-06.2008 3 10.1523/JNEUROSCI.1565-06.2008 false true Reference 3513925 /api/reference/3513925 4. Almási 2003: Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: a novel heat allodynia model sensitive to analgesics, Br. J. Pharmacol, 139, p. 49, DOI: 10.1038/sj.bjp.0705234 4 10.1038/sj.bjp.0705234 false true Reference 3513926 /api/reference/3513926 5. Bandell 2004: Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin, Neuron, 41, p. 849, DOI: 10.1016/S0896-6273(04)00150-3 5 10.1016/S0896-6273(04)00150-3 false true Reference 3513927 /api/reference/3513927 6. Bari 2005: Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis, J. Biol. Chem, 280, p. 12212, DOI: 10.1074/jbc.M411642200 6 10.1074/jbc.M411642200 false true Reference 3513928 /api/reference/3513928 7. Bautista 2013: TRPA1: a gatekeeper for inflammation, Annu. Rev. Physiol, 75, p. 181, DOI: 10.1146/annurev-physiol-030212-183811 7 10.1146/annurev-physiol-030212-183811 false true Reference 3513929 /api/reference/3513929 8. Bergdahl 2003: Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca2+ entry dependent on TRPC1, Circ. Res, 93, p. 839, DOI: 10.1161/01.RES.0000100367.45446.A3 8 10.1161/01.RES.0000100367.45446.A3 false true Reference 3513930 /api/reference/3513930 9. Bianchi 2006: Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system, Eur. J. Pharmacol, 537, p. 20, DOI: 10.1016/j.ejphar.2006.03.003 9 10.1016/j.ejphar.2006.03.003 false true Reference 3513931 /api/reference/3513931 10. Bölcskei 2005: Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice, Pain, 117, p. 368, DOI: 10.1016/j.pain.2005.06.024 10 10.1016/j.pain.2005.06.024 false true Reference 3513932 /api/reference/3513932 11. Brizzi 2014: Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: identification of a dual cannabinoid receptor/TRPA1 channel agonist, Bioorg. Med. Chem, 22, p. 4770, DOI: 10.1016/j.bmc.2014.07.006 11 10.1016/j.bmc.2014.07.006 false true Reference 3513933 /api/reference/3513933 12. Cao 2013: TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids, Neuron, 77, p. 667, DOI: 10.1016/j.neuron.2012.12.016 12 10.1016/j.neuron.2012.12.016 false true Reference 3513934 /api/reference/3513934 13. Caterina 2006: TRPV1: a polymodal sensor in the nociceptor terminal, Current topics in membranes, p. 113 13 false true Reference 3513935 /api/reference/3513935 14. Chao 2011: Two-dimensional solvent-mediated phase transformation in lipid membranes induced by sphingomyelinase, Langmuir, 27, p. 10050, DOI: 10.1021/la2015836 14 10.1021/la2015836 false true Reference 3513936 /api/reference/3513936 15. Chen 1993: Cholesterol and sphingomyelin syntheses are regulated independently in cultured human intestinal cells, CaCo-2: role of membrane cholesterol and sphingomyelin content, J. Lipid Res, 34, p. 2159, DOI: 10.1016/S0022-2275(20)35356-6 15 10.1016/S0022-2275(20)35356-6 false true Reference 3513937 /api/reference/3513937 16. Corey 2004: TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells, Nature, 432, p. 723, DOI: 10.1038/nature03066 16 10.1038/nature03066 false true Reference 3513938 /api/reference/3513938 17. De Chiara 2013: Interleukin-1β alters the sensitivity of cannabinoid CB1 receptors controlling glutamate transmission in the striatum, Neuroscience, 250, p. 232, DOI: 10.1016/j.neuroscience.2013.06.069 17 10.1016/j.neuroscience.2013.06.069 false true Reference 3513939 /api/reference/3513939 18. De Logu 2019: Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice, J. Clin. Invest, 129, p. 5424, DOI: 10.1172/JCI128022 18 10.1172/JCI128022 false true Reference 3513940 /api/reference/3513940 19. Dina 2005: Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia, Pain, 115, p. 191, DOI: 10.1016/j.pain.2005.02.028 19 10.1016/j.pain.2005.02.028 false true Reference 3513941 /api/reference/3513941 20. Ferrari 2015: Plasma membrane mechanisms in a preclinical rat model of chronic pain, J. Pain, 16, p. 60, DOI: 10.1016/j.jpain.2014.10.007 20 10.1016/j.jpain.2014.10.007 false true Reference 3513942 /api/reference/3513942 21. Gambert 2017: Cholesterol metabolism and glaucoma: modulation of Muller cell membrane organization by 24S-hydroxycholesterol, Chem. Phys. Lipids, 207, p. 179, DOI: 10.1016/j.chemphyslip.2017.05.007 21 10.1016/j.chemphyslip.2017.05.007 false true Reference 3513943 /api/reference/3513943 22. Gaus 2003: Visualizing lipid structure and raft domains in living cells with two-photon microscopy, Proc. Natl. Acad. Sci. U.S.A, 100, p. 15554, DOI: 10.1073/pnas.2534386100 22 10.1073/pnas.2534386100 false true Reference 3513944 /api/reference/3513944 23. Gavva 2008: Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1, Trends Pharmacol. Sci, 29, p. 550, DOI: 10.1016/j.tips.2008.08.003 23 10.1016/j.tips.2008.08.003 false true Reference 3513945 /api/reference/3513945 24. Gees 2012: TRP channels, Comprehensive physiology, p. 563, DOI: 10.1002/cphy.c110026 24 10.1002/cphy.c110026 false true Reference 3513946 /api/reference/3513946 25. Graziani 2006: Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy, Biochem. J, 396, p. 147, DOI: 10.1042/BJ20051246 25 10.1042/BJ20051246 false true Reference 3513947 /api/reference/3513947 26. Harris 2002: Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order, Biochim. Biophys. Acta, 1565, p. 123, DOI: 10.1016/S0005-2736(02)00514-X 26 10.1016/S0005-2736(02)00514-X false true Reference 3513948 /api/reference/3513948 27. Helyes 2003: Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat, Life Sci, 73, p. 2345, DOI: 10.1016/S0024-3205(03)00651-9 27 10.1016/S0024-3205(03)00651-9 false true Reference 3513949 /api/reference/3513949 28. Helyes 2009: Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice, Proc. Natl. Acad. Sci. U.S.A, 106, p. 13088, DOI: 10.1073/pnas.0900681106 28 10.1073/pnas.0900681106 false true Reference 3513950 /api/reference/3513950 29. Horváth 2020: Antinociceptive effects of lipid raft disruptors, a novel carboxamido-steroid and methyl β-cyclodextrin, in mice by inhibiting transient receptor potential vanilloid 1 and Ankyrin 1 channel activation, Front. Physiol, 11, p. 559109, DOI: 10.3389/fphys.2020.559109 29 10.3389/fphys.2020.559109 false true Reference 3513951 /api/reference/3513951 30. Hwang 2000: Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances, Proc. Natl. Acad. Sci. U.S.A, 97, p. 6155, DOI: 10.1073/pnas.97.11.6155 30 10.1073/pnas.97.11.6155 false true Reference 3513952 /api/reference/3513952 31. Jordt 2004: Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1, Nature, 427, p. 260, DOI: 10.1038/nature02282 31 10.1038/nature02282 false true Reference 3513953 /api/reference/3513953 32. Kaneko 2014: Transient receptor potential (TRP) channels: a clinical perspective, Br. J. Pharmacol, 171, p. 2474, DOI: 10.1111/bph.12414 32 10.1111/bph.12414 false true Reference 3513954 /api/reference/3513954 33. Kántás 2019: Novel drug-like somatostatin receptor 4 agonists are potential analgesics for neuropathic pain, Int. J. Mol. Sci, 20, p. 6245, DOI: 10.3390/ijms20246245 33 10.3390/ijms20246245 false true Reference 3513955 /api/reference/3513955 34. Kiyokawa 2005: Spatial and functional heterogeneity of sphingolipid-rich membrane domains, J. Biol. Chem, 280, p. 24072, DOI: 10.1074/jbc.M502244200 34 10.1074/jbc.M502244200 false true Reference 3513956 /api/reference/3513956 35. Kobayashi 2006: Lipid rafts: new tools and a new component, Biol. Pharm. Bull, 29, p. 1526, DOI: 10.1248/bpb.29.1526 35 10.1248/bpb.29.1526 false true Reference 3513957 /api/reference/3513957 36. Lee 2011: Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2)/M phase arrest, Cell Prolif, 44, p. 320, DOI: 10.1111/j.1365-2184.2011.00761.x 36 10.1111/j.1365-2184.2011.00761.x false true Reference 3513958 /api/reference/3513958 37. Lee 2012: Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis, Cancer Biol. Ther, 13, p. 92, DOI: 10.4161/cbt.13.2.18870 37 10.4161/cbt.13.2.18870 false true Reference 3513959 /api/reference/3513959 38. Lee 2014: PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts, J. Neurosci, 34, p. 16140, DOI: 10.1523/JNEUROSCI.1908-14.2014 38 10.1523/JNEUROSCI.1908-14.2014 false true Reference 3513960 /api/reference/3513960 39. Li 2009: Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol, Biochim. Biophys. Acta, 1791, p. 297, DOI: 10.1016/j.bbalip.2009.01.010 39 10.1016/j.bbalip.2009.01.010 false true Reference 3513961 /api/reference/3513961 40. Lin 2019: Treatment with methyl-β-cyclodextrin prevents mechanical allodynia in resiniferatoxin neuropathy in a mouse model, Biol. Open, 8, p. bio039511, DOI: 10.1242/bio.039511 40 10.1242/bio.039511 false true Reference 3513962 /api/reference/3513962 41. Liu 2003: Thermodynamics of heat activation of single capsaicin ion channels VR1, Biophys. J, 85, p. 2988, DOI: 10.1016/S0006-3495(03)74719-5 41 10.1016/S0006-3495(03)74719-5 false true Reference 3513963 /api/reference/3513963 42. Liu 2006: TRPV1, but not P2X, requires cholesterol for its function and membrane expression in rat nociceptors, Eur. J. Neurosci, 24, p. 1, DOI: 10.1111/j.1460-9568.2006.04889.x 42 10.1111/j.1460-9568.2006.04889.x false true Reference 3513964 /api/reference/3513964 43. Lockwich 2000: Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains, J. Biol. Chem, 275, p. 11934, DOI: 10.1074/jbc.275.16.11934 43 10.1074/jbc.275.16.11934 false true Reference 3513965 /api/reference/3513965 44. Macpherson 2005: The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin, Curr. Biol, 15, p. 929, DOI: 10.1016/j.cub.2005.04.018 44 10.1016/j.cub.2005.04.018 false true Reference 3513966 /api/reference/3513966 45. Macpherson 2007: Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines, Nature, 445, p. 541, DOI: 10.1038/nature05544 45 10.1038/nature05544 false true Reference 3513967 /api/reference/3513967 46. Marrone 2017: TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice, Nat. Commun, 8, p. 15292, DOI: 10.1038/ncomms15292 46 10.1038/ncomms15292 false true Reference 3513968 /api/reference/3513968 47. McNamara 2007: TRPA1 mediates formalin-induced pain, Proc. Natl. Acad. Sci. U.S.A, 104, p. 13525, DOI: 10.1073/pnas.0705924104 47 10.1073/pnas.0705924104 false true Reference 3513969 /api/reference/3513969 48. Meyer 1981: Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand, Science, 213, p. 1527, DOI: 10.1126/science.7280675 48 10.1126/science.7280675 false true Reference 3513970 /api/reference/3513970 49. Miyake 1995: Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/Myriocin, Biochem. Biophys. Res. Commun, 211, p. 396, DOI: 10.1006/bbrc.1995.1827 49 10.1006/bbrc.1995.1827 false true Reference 3513971 /api/reference/3513971 50. Moran 2011: Transient receptor potential channels as therapeutic targets, Nat. Rev. Drug Discov, 10, p. 601, DOI: 10.1038/nrd3456 50 10.1038/nrd3456 false true Reference 3513972 /api/reference/3513972 51. Morenilla-Palao 2009: Lipid raft segregation modulates TRPM8 channel activity, J. Biol. Chem, 284, p. 9215, DOI: 10.1074/jbc.M807228200 51 10.1074/jbc.M807228200 false true Reference 3513973 /api/reference/3513973 52. Myers 2008: A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating, Neuron, 58, p. 362, DOI: 10.1016/j.neuron.2008.04.012 52 10.1016/j.neuron.2008.04.012 false true Reference 3513974 /api/reference/3513974 53. Nilius 2014: Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine, Pharmacol. Rev, 66, p. 676, DOI: 10.1124/pr.113.008268 53 10.1124/pr.113.008268 false true Reference 3513975 /api/reference/3513975 54. Pan 2003: Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action, J. Neurosci, 23, p. 2911, DOI: 10.1523/JNEUROSCI.23-07-02911.2003 54 10.1523/JNEUROSCI.23-07-02911.2003 false true Reference 3513976 /api/reference/3513976 55. Payrits 2017: Estradiol sensitizes the transient receptor potential vanilloid 1 receptor in pain responses, Endocrinology, 158, p. 3249, DOI: 10.1210/en.2017-00101 55 10.1210/en.2017-00101 false true Reference 3513977 /api/reference/3513977 56. Raisinghani 2005: Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin, J. Physiol, 567, p. 771, DOI: 10.1113/jphysiol.2005.087874 56 10.1113/jphysiol.2005.087874 false true Reference 3513978 /api/reference/3513978 57. Ridgway 2000: Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin, Biochim. Biophys. Acta, 1484, p. 129, DOI: 10.1016/S1388-1981(00)00006-8 57 10.1016/S1388-1981(00)00006-8 false true Reference 3513979 /api/reference/3513979 58. Rossi 2012: Interleukin-1β causes anxiety by interacting with the endocannabinoid system, J. Neurosci, 32, p. 13896, DOI: 10.1523/JNEUROSCI.1515-12.2012 58 10.1523/JNEUROSCI.1515-12.2012 false true Reference 3513980 /api/reference/3513980 59. Sághy 2015: Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals, Pharmacol. Res, 100, p. 101, DOI: 10.1016/j.phrs.2015.07.028 59 10.1016/j.phrs.2015.07.028 false true Reference 3513981 /api/reference/3513981 60. Salas 2009: TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1, Eur. J. Neurosci, 29, p. 1568, DOI: 10.1111/j.1460-9568.2009.06702.x 60 10.1111/j.1460-9568.2009.06702.x false true Reference 3513982 /api/reference/3513982 61. Sántha 2020: Role of gangliosides in peripheral pain mechanisms, Int. J. Mol. Sci, 21, p. 1005, DOI: 10.3390/ijms21031005 61 10.3390/ijms21031005 false true Reference 3513983 /api/reference/3513983 62. Sauer 2017: A novel approach for the control of inflammatory pain: prostaglandin E2 complexation by randomly methylated β-cyclodextrins, Anesth. Analg, 124, p. 675, DOI: 10.1213/ANE.0000000000001674 62 10.1213/ANE.0000000000001674 false true Reference 3513984 /api/reference/3513984 63. Sharma 2013: Mechanisms and clinical uses of capsaicin, Eur. J. Pharmacol, 720, p. 55, DOI: 10.1016/j.ejphar.2013.10.053 63 10.1016/j.ejphar.2013.10.053 false true Reference 3513985 /api/reference/3513985 64. Simons 1997: Functional rafts in cell membranes, Nature, 387, p. 569, DOI: 10.1038/42408 64 10.1038/42408 false true Reference 3513986 /api/reference/3513986 65. Smart 2000: The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1), Br. J. Pharmacol, 129, p. 227, DOI: 10.1038/sj.bjp.0703050 65 10.1038/sj.bjp.0703050 false true Reference 3513987 /api/reference/3513987 66. Sonnino 2014: Lipid rafts in neurodegeneration and neuroprotection, Mol. Neurobiol, 50, p. 130, DOI: 10.1007/s12035-013-8614-4 66 10.1007/s12035-013-8614-4 false true Reference 3513988 /api/reference/3513988 67. Story 2003: ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures, Cell, 112, p. 819, DOI: 10.1016/S0092-8674(03)00158-2 67 10.1016/S0092-8674(03)00158-2 false true Reference 3513989 /api/reference/3513989 68. Szőke 2002: Neonatal capsaicin treatment results in prolonged mitochondrial damage and delayed cell death of B cells in the rat trigeminal ganglia, Neuroscience, 113, p. 925, DOI: 10.1016/s0306-4522(02)00208-7 68 10.1016/s0306-4522(02)00208-7 false true Reference 3513990 /api/reference/3513990 69. Szolcsányi 2004: Forty years in capsaicin research for sensory pharmacology and physiology, Neuropeptides, 38, p. 377, DOI: 10.1016/j.npep.2004.07.005 69 10.1016/j.npep.2004.07.005 false true Reference 3513991 /api/reference/3513991 70. Szolcsányi 2008: Hot target on nociceptors: perspectives, caveats and unique features, Br. J. Pharmacol, 155, p. 1142, DOI: 10.1038/bjp.2008.374 70 10.1038/bjp.2008.374 false true Reference 3513992 /api/reference/3513992 71. Szolcsányi 1975: Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin, Naunyn Schmiedebergs Arch. Pharmacol, 287, p. 157, DOI: 10.1007/BF00510447 71 10.1007/BF00510447 false true Reference 3513993 /api/reference/3513993 72. Szolcsányi 2012: Multisteric TRPV1 nocisensor: a target for analgesics, Trends Pharmacol. Sci, 33, p. 646, DOI: 10.1016/j.tips.2012.09.002 72 10.1016/j.tips.2012.09.002 false true Reference 3513994 /api/reference/3513994 73. Szőke 2010: Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell line, Eur. J. Pharmacol, 628, p. 67, DOI: 10.1016/j.ejphar.2009.11.052 73 10.1016/j.ejphar.2009.11.052 false true Reference 3513995 /api/reference/3513995 74. Tjølsen 1992: The formalin test: an evaluation of the method, Pain, 51, p. 5, DOI: 10.1016/0304-3959(92)90003-t 74 10.1016/0304-3959(92)90003-t false true Reference 3513996 /api/reference/3513996 75. Trevisani 2007: 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1, Proc. Natl. Acad. Sci. U.S.A, 104, p. 13519, DOI: 10.1073/pnas.0705923104 75 10.1073/pnas.0705923104 false true Reference 3513997 /api/reference/3513997 76. Vay 2012: The thermo-TRP ion channel family: properties and therapeutic implications, Br. J. Pharmacol, 165, p. 787, DOI: 10.1111/j.1476-5381.2011.01601.x 76 10.1111/j.1476-5381.2011.01601.x false true Reference 3513998 /api/reference/3513998 77. Vilceanu 2010: TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons, PLoS One, 5, p. e12177, DOI: 10.1371/journal.pone.0012177 77 10.1371/journal.pone.0012177 false true Reference 3513999 /api/reference/3513999 78. Watanabe 2011: Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism, Pain, 152, p. 327, DOI: 10.1016/j.pain.2010.10.036 78 10.1016/j.pain.2010.10.036 false true Reference 3514000 /api/reference/3514000 79. Welch 2000: The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat, Proc. Natl. Acad. Sci. U.S.A, 97, p. 13889, DOI: 10.1073/pnas.230146497 79 10.1073/pnas.230146497 false true /api/publication/31848850 Horváth Ádám et al. Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation. (2021) FRONTIERS IN PHARMACOLOGY 1663-9812 11<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071348"><a href="/gui2/?type=authors&mode=browse&sel=10071348" target="_blank">Horváth Ádám ✉ (<span class="authorship-author-name">Horváth Ádám</span> <span class="authorAux-mtmt"> Fájdalomkutatás</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039773"><a href="/gui2/?type=authors&mode=browse&sel=10039773" target="_blank">Payrits Maja (<span class="authorship-author-name">Payrits Maja</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037472"><a href="/gui2/?type=authors&mode=browse&sel=10037472" target="_blank">Steib Anita (<span class="authorship-author-name">Steib Anita</span> <span class="authorAux-mtmt"> Biológia, Állatszervezettan</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/Szentágothai Research Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071349"><a href="/gui2/?type=authors&mode=browse&sel=10071349" target="_blank">Kántás Boglárka (<span class="authorship-author-name">Kántás Boglárka</span> <span class="authorAux-mtmt"> Fájdalomkutatás</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067039"><a href="/gui2/?type=authors&mode=browse&sel=10067039" target="_blank">Biró-Sütő Tünde (<span class="authorship-author-name">Biró-Sütő Tünde</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003159"><a href="/gui2/?type=authors&mode=browse&sel=10003159" target="_blank">Erostyák János (<span class="authorship-author-name">Erostyák János</span> <span class="authorAux-mtmt"> Fluoreszcencia spektroszkópia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Spectroscopy Research Group; <span title="University of Pécs">UP</span>/<span title="Faculty of Sciences">FS</span>/<span title="Institute of Physics">IP</span>/Department of Experimental Physics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016877"><a href="/gui2/?type=authors&mode=browse&sel=10016877" target="_blank">Makkai Géza (<span class="authorship-author-name">Makkai Géza</span> <span class="authorAux-mtmt"> Fizika</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Faculty of Sciences">FS</span>/<span title="Institute of Physics">IP</span>/Department of Experimental Physics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037547"><a href="/gui2/?type=authors&mode=browse&sel=10037547" target="_blank">Sághy Éva (<span class="authorship-author-name">Sághy Éva</span> <span class="authorAux-mtmt"> Gyógyszertudományok, farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001426"><a href="/gui2/?type=authors&mode=browse&sel=10001426" target="_blank">Helyes Zsuzsanna (<span class="authorship-author-name">Helyes Zsuzsanna</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019144"><a href="/gui2/?type=authors&mode=browse&sel=10019144" target="_blank">Szőke Éva (<span class="authorship-author-name">Szőke Éva</span> <span class="authorAux-mtmt"> Fájdalomkutatás</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31848850" target="_blank">Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation</a></div> <div> <span class="journal-title">FRONTIERS IN PHARMACOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1663-9812">1663-9812</a>)</span>: <span class="journal-volume">11</span> <span class="page"> Paper 593319. 11 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fphar.2020.593319" target="_blank" href="https://doi.org/10.3389/fphar.2020.593319"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000616632700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000616632700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85100818388" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85100818388"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33584270" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33584270&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 22</span> | Independent citation: 15 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 20 | Number of citations in Scopus:&nbsp;20 | WoS/Scopus assigned:&nbsp;20 | Number of citations with DOI:&nbsp;21 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31848850&sort=publishedYear,desc&sort=title"> Number of cited publications: 18 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31848850</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-18-4), (17886-4/23018/FEKUTSTRAT), (ÚNKP-19-4), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (GINOP- 2.3.2-15- 2016-00050 “PEPSYS”), EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Funder: NRDIO, (EFOP-3.6.2.-16-2017-00008) </div> <div class="lastModified">Last Modified: 2025.12.05. 08:46 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:10 Gusztáv Ladányi (MTMT API user, admin) Zsófia Orbán (MTMT ellenőrzés, admin) </div> </div></div>