https://m2.mtmt.hu/ hun 2026-09-21 03:48 JournalArticle 31822065 VALIDATED true 0 false 2026-08-03T08:38:45.579+0000 2024-05-23T06:26:24.348+0000 2021-01-21T13:12:43.823+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 2024-06-03T08:00:00.320+0000 2024-06-03T08:00:00.320+0000 2021-02-22T14:21:44.219+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Ali, S.R. Real-World Estimates of Adrenal Insufficiency-Related Adverse Events in Children With Congenital Adrenal Hyperplasia true true /api/journal/10030700 REVIEWED true false 10030700 false 10030700 true 0021-972X 1945-7197 Journal FOREIGN 106 1 e192 e203 e192 12 2021 BACKGROUND: Although congenital adrenal hyperplasia (CAH) is known to be associated with adrenal crises (AC), its association with patient- or clinician-reported sick day episodes (SDE) is less clear. METHODS: Data on children with classic 21-hydroxylase deficiency CAH from 34 centers in 18 countries, of which 7 were Low or Middle Income Countries (LMIC) and 11 were High Income (HIC), were collected from the International CAH Registry and analyzed to examine the clinical factors associated with SDE and AC. RESULTS: A total of 518 children-with a median of 11 children (range 1, 53) per center-had 5388 visits evaluated over a total of 2300 patient-years. The median number of AC and SDE per patient-year per center was 0 (0, 3) and 0.4 (0.0, 13.3), respectively. Of the 1544 SDE, an AC was reported in 62 (4%), with no fatalities. Infectious illness was the most frequent precipitating event, reported in 1105 (72%) and 29 (47%) of SDE and AC, respectively. On comparing cases from LMIC and HIC, the median SDE per patient-year was 0.75 (0, 13.3) vs 0.11 (0, 12.0) (P < 0.001), respectively, and the median AC per patient-year was 0 (0, 2.2) vs 0 (0, 3.0) (P = 0.43), respectively. CONCLUSIONS: The real-world data that are collected within the I-CAH Registry show wide variability in the reported occurrence of adrenal insufficiency-related adverse events. As these data become increasingly used as a clinical benchmark in CAH care, there is a need for further research to improve and standardize the definition of SDE. © The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. 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;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060259"><a href="/gui2/?type=authors&mode=browse&sel=10060259" target="_blank">Korbonits M. (<span class="authorship-author-name">Korbonits Márta</span> <span class="authorAux-mtmt"> Endokrinologia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023441"><a href="/gui2/?type=authors&mode=browse&sel=10023441" target="_blank">Luczay A. (<span class="authorship-author-name">Luczay Andrea</span> <span class="authorAux-mtmt"> Gyermekgyógyászat endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; et al. (47) </div> <div><a target="_blank" href="/api/publication/31822065?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31822065" target="_blank">Real-World Estimates of Adrenal Insufficiency-Related Adverse Events in Children With Congenital Adrenal Hyperplasia</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0021-972X">0021-972X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7197">1945-7197</a>)</span>: <span class="journal-volume">106</span> <span class="journal-issue">1</span> <span class="page"> pp e192-e203 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1210/clinem/dgaa694" target="_blank" href="https://doi.org/10.1210/clinem/dgaa694"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000608480200018" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000608480200018"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8934" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8934"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85099073104" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85099073104"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32995889" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32995889&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 37</span> | Független: 23 | Függő: 14 | Nem jelölt: 0 | WoS jelölt: 36 | Scopus jelölt:&nbsp;29 | WoS/Scopus jelölt:&nbsp;37 | DOI jelölt:&nbsp;37 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31822065</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (G1100236), (201444) </div> <div class="lastModified">Utolsó módosítás: 2024.05.23. 08:26 Korbonits Márta (Endokrinologia) </div> </div></div>