The faulty hormonal imprinting theory (published in 1980) and the DOHaD (Developmental
Origin of Health and Disease theory (published in 1986) are twin-concepts: both justify
the manifestation after long time (in adults) diseases which had been provoked in
differentiating cells (e.g. during gestation). This was demonstrated using animal
experiments as well, as comparative statistical methods (in human cases). However,
there is no explanation for the tools of memorization (even after decades) of the
early adversity and the tools of execution (manifestation) in adult age. It seems
likely that immune memory is involved to the memorization of early adversity, up to
the manifestation of the result (non-communicable diseases). Nevertheless, the relatively
short timespan of adaptive immune memory makes this system insuitable for this function,
however the newly recognized trained memory of the innate immune system seems to be
theoretically suitable for the storage of the records and handling the sequalae, which
is the epigenetic reprogramming in the time of provocation, without changes in base
sequences (mutation). The flawed (damaged) program is manifested later, in adult age.
Evidences are incomplete, so further animal experiments and human observations are
needed for justifying the theory.
