LIVE LONGER - Modern orvostudományi diagnosztikus eljárások és terápiák fejlesztése
transzlációs ...(EFOP 3.6.2-16-2017-00006 (LIVE LONGER).) Támogató: EFOP
(GINOP-2.3.2-15-2016-00048)
Szakterületek:
Járványtan
Onkológia
Szövettan
BackgroundThe epidemiology of esophageal cancer has changed dramatically over
the past 4 decades in many Western populations. We aimed to understand the Hungarian
epidemiologic trends of esophageal squamous cell cancer (SCC) and adenocarcinoma (AC).MethodsWe
performed a cross-sectional study using data from esophageal cancer patients diagnosed
between 1992 and 2018 at eight tertiary referral centers in four major cities of Hungary.
We retrospectively identified cases in the electronic databases of each center and
collected data on gender, age at diagnosis, year of diagnosis, specialty of the origin
center, histological type, and localization of the tumor. Patients were grouped based
on the two main histological types: AC or SCC. For statistical analysis, we used linear
regression models, chi-square tests, and independent sample t tests.ResultsWe
extracted data on 3,283 patients with esophageal cancer. Of these, 2,632 were diagnosed
with either of the two main histological types; 737 had AC and 1,895 SCC. There was
no significant difference in the gender ratio of the patients between AC and SCC (80.1
vs 81.8% males, respectively; p = 0.261). The relative incidence of AC increased over
the years (p < 0.001, b = 1.19 CI: 0.84–1.54). AC patients were older at diagnosis
than SCC patients (64.37 ± 11.59 vs 60.30 ± 10.07 years, p < 0.001). The age of patients
at the diagnosis of primary esophageal cancer increased over time (p < 0.001, R =
0.119).ConclusionsThe rapid increase in the relative incidence of AC and
simultaneous decrease of the relative incidence of SCC suggest that this well-established
Western phenomenon is also present in Hungary.
