https://m2.mtmt.hu/ hun 2026-05-25 00:55 JournalArticle 31797139 ADMIN_APPROVED true Department of Rheumatology, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands Department of Rheumatology, Bács-Kiskun County Hospital, Kecskemét, Hungary Department of Rheumatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Rheumatology, Meander Medical Center, Amersfoort, Netherlands Salisbury Foundation Trust Nhs Hospital, Wiltshire, United Kingdom Eular Standing Committee of People with Arthritis/Rheumatism in Europe (PARE), Zurich, Switzerland Department of Rheumatology, 1st Faculty of Medicine, Charles University and Institute of Rheumatology, Prague, Czech Republic Create Centre, Section of Rheumatology, School of Medicine, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom Univ. de Paris Dept. of Rheumatology-Hop. Cochin Assit. Pub.-Hop. de Paris Inserm (U1153): Clin. Epidemiol. and Biostatist., Pres Sorbonne Paris-Cité, Paris, France Department of Psychology, Utrecht University, Utrecht, Netherlands Epidemiology Unit, German Rheumatism Research Centre, and Rheumatology, Charité University Medicine, Berlin, Germany Department of Internal Medicine Iii, Division of Rheumatology, Medical University of Vienna, Vienna, Austria Department of Rheumatology, Bravis Hospital, Roosendaal, Netherlands Department of Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands Department of Pharmacy, Paris Descartes University, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France School of Health and Society, Centre for Health Sciences Research, University of Salford, Salford, United Kingdom Centre for Rheumatic Diseases, King's College London, London, United Kingdom School of Medicine, Catholic University of the Sacred Heart, Rome, Italy Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University of Erlangen-Nuremberg and Universitatsklinikum Erlangen, Erlangen, Germany Nihr Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Nhs Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Kerckhoff Clinic Bad Nauheim, Bad Nauheim, Germany Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands Cited By :256 Export Date: 5 October 2024 CODEN: ARDIA Correspondence Address: Nagy, G.; Department of Rheumatology, Hungary; email: nagy.gyorgy2@med.semmelweis-univ.hu 0 false 2026-05-21T06:17:59.215+0000 2026-04-26T15:31:48.278+0000 2021-01-05T13:24:03.283+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 2026-04-26T15:31:48.781+0000 2026-04-26T15:31:48.781+0000 2024-04-09T10:11:12.042+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:21:58.800+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Nagy, G. EULAR definition of difficult-To-Treat rheumatoid arthritis true true /api/journal/383 REVIEWED true false 383 false 383 true 0003-4967 1468-2060 Journal FOREIGN 80 1 31 35 31 5 2021 Background Despite treatment according to the current management recommendations, a significant proportion of patients with rheumatoid arthritis (RA) remain symptomatic. These patients can be considered to have ♭difficult-to-treat RA'. However, uniform terminology and an appropriate definition are lacking. Objective The Task Force in charge of the "Development of EULAR recommendations for the comprehensive management of difficult-to-treat rheumatoid arthritis" aims to create recommendations for this underserved patient group. Herein, we present the definition of difficult-to-treat RA, as the first step. Methods The Steering Committee drafted a definition with suggested terminology based on an international survey among rheumatologists. This was discussed and amended by the Task Force, including rheumatologists, nurses, health professionals and patients, at a face-to-face meeting until sufficient agreement was reached (assessed through voting). Results The following three criteria were agreed by all Task Force members as mandatory elements of the definition of difficult-to-treat RA: (1) Treatment according to European League Against Rheumatism (EULAR) recommendation and failure of ?2 biological disease-modifying antirheumatic drugs (DMARDs)/targeted synthetic DMARDs (with different mechanisms of action) after failing conventional synthetic DMARD therapy (unless contraindicated); (2) presence of at least one of the following: at least moderate disease activity; signs and/or symptoms suggestive of active disease; inability to taper glucocorticoid treatment; rapid radiographic progression; RA symptoms that are causing a reduction in quality of life; and (3) the management of signs and/or symptoms is perceived as problematic by the rheumatologist and/or the patient. Conclusions The proposed EULAR definition for difficult-to-treat RA can be used in clinical practice, clinical trials and can form a basis for future research. true true 2021 true true true false true false NONE 2026-05-21 false 544 1 544 472 32 542 521 489 448 535 535 464 464 472 72 0 544 472 544 472 0 2 2 Folyóiratcikk Journal Article 24 541 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 38 29 38 29 2022 0 72 58 72 58 2023 0 97 82 97 82 2024 0 122 108 122 108 2025 0 150 136 150 136 2026 0 65 59 65 59 D1 true 10057639 false false false 2021-01-04T13:31:12.059+0000 Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); III. 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Belgyógyászati Klinika (SE / AOK / K); Reumatológiai Tanszék (DE / ÁOK / BelgyI); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK) 4 31 4 31 0 true 10097590 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 94991961 /api/authorship/94991961 1 0.0 true false true Author 10025749 /api/author/10025749 Nagy György true 10025749 true Nagy G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991962 /api/authorship/94991962 2 0.0 false false false Roodenrijs N.M.T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991963 /api/authorship/94991963 3 0.0 false false false Welsing P.M.J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991964 /api/authorship/94991964 4 0.0 false false false Author 10094727 /api/author/10094727 Kedves Melinda true true Kedves M. true false false AuthorshipType 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/api/authorship/94991970 10 0.0 false false false Senolt L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991971 /api/authorship/94991971 11 0.0 false false false Author 10003464 /api/author/10003464 Szekanecz Zoltán true 10003464 true Szekanecz Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991972 /api/authorship/94991972 12 0.0 false false false Choy E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991973 /api/authorship/94991973 13 0.0 false false false Dougados M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991974 /api/authorship/94991974 14 0.0 false false false Jacobs J.W.G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991975 /api/authorship/94991975 15 0.0 false false false Geenen R. true false false 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true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991982 /api/authorship/94991982 22 0.0 false false false Prior Y. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991983 /api/authorship/94991983 23 0.0 false false false Nikiphorou E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991984 /api/authorship/94991984 24 0.0 false false false Ferraccioli G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991985 /api/authorship/94991985 25 0.0 false false false Schett G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991986 /api/authorship/94991986 26 0.0 false false false Hyrich K.L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94991987 /api/authorship/94991987 27 0.0 false false 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/api/publication/31797139 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy G. ✉ (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094727"><a href="/gui2/?type=authors&mode=browse&sel=10094727" target="_blank">Kedves M. (<span class="authorship-author-name">Kedves Melinda</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057639"><a href="/gui2/?type=authors&mode=browse&sel=10057639" target="_blank">Hamar A. (<span class="authorship-author-name">Hamar Attila</span> <span class="authorAux-mtmt"> általános orvos</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Reumatológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003464"><a href="/gui2/?type=authors&mode=browse&sel=10003464" target="_blank">Szekanecz Z. (<span class="authorship-author-name">Szekanecz Zoltán</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Reumatológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (31) </div> <div><a target="_blank" href="/api/publication/31797139?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31797139" target="_blank">EULAR definition of difficult-To-Treat rheumatoid arthritis</a></div> <div> <span class="journal-title">ANNALS OF THE RHEUMATIC DISEASES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0003-4967">0003-4967</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1468-2060">1468-2060</a>)</span>: <span class="journal-volume">80</span> <span class="journal-issue">1</span> <span class="page"> pp 31-35 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1136/annrheumdis-2020-217344" target="_blank" href="https://doi.org/10.1136/annrheumdis-2020-217344"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000607296800019" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000607296800019"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85098069546" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85098069546"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33004335" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33004335&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2020-217344" target="_blank" href="https://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2020-217344"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Rheumatology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 544</span> | Független: 472 | Függő: 72 | Nem jelölt: 0 | WoS jelölt: 489 | Scopus jelölt:&nbsp;448 | WoS/Scopus jelölt:&nbsp;535 | DOI jelölt:&nbsp;521 (Nem nyilvános:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31797139&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31797139</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2026.04.26. 17:31 Áts József (ÁtsJ adm2-3, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:21 Ladányi Gusztáv (MTMT API user, admin) Orbán Zsófia (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Rheumatology, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands De...</pre> </div></div>