https://m2.mtmt.hu/ hun 2026-09-21 13:29 JournalArticle 31793659 VALIDATED true Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7, Budapest, 1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, 1111, Hungary ViteCer Ltd., Ipartelepi Str. 8/b, Cegléd, 2700, Hungary Cited By :3 Export Date: 23 September 2022 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Str. 7, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu 0 false 2026-07-02T08:12:54.130+0000 2022-05-31T12:59:00.020+0000 2021-01-02T18:21:05.179+0000 true 10002587 Zelkó Romána /api/author/10002587 Author Zelkó Romána (Gyógyszertechnológia) true 10002587 2026-06-03T11:22:44.518+0000 2026-06-03T11:22:44.518+0000 2022-05-31T12:59:00.349+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin Berhidi Anna (SE_KK_Admin5_BA, admin) true 10015546 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Sántha, Konrád true true /api/journal/10005393 REVIEWED AAPS PHARMSCITECH 1530-9932 1530-9932 true false 10005393 false 10005393 true 1530-9932 1530-9932 Journal FOREIGN 22 1 14 14 10 2021 Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods. The information obtained from the independent evaluation of the in vitro drug release profiles model is confirmed by the results obtained by image analysis, regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were used for image analysis. The results of this study show that the novel easy-to-use, fast, and non-destructive MFX method is a good alternative to the already used microscopic image analysis methods regarding the characterization of particulates, compressed into tablets. Funding 2014463 /api/funding/2014463 (KFI_16-1-2017-0025) Támogató: NKFIH false true Funding 2014464 /api/funding/2014464 (Open access funding provided by Semmelweis University) false true true true NATIONAL 2021 true true true false true false GOLD 2026-07-02 true https://doi.org/10.1208/s12249-020-01902-x 11 0 11 8 4 11 11 8 11 11 11 8 8 8 3 0 11 8 11 8 0 3 3 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 1 1 1 2022 0 2 0 2 0 2023 0 0 0 0 0 2024 0 4 3 4 3 2025 0 2 2 2 2 2026 0 2 2 2 2 Q2 false false false false 2021-01-04T12:51:25.764+0000 Elektronikai Technológia Tanszék (BME / VIK); Gyógyszerészeti Intézet (SE / GYTK) 8 12 2 8 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 94953930 /api/authorship/94953930 Sántha, Konrád [Sántha, Konrád (gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 1 0.125 true false false Author 10061230 /api/author/10061230 Sántha Konrád (gyógyszertechnológia) Sántha Konrád true 10061230 true Sántha Konrád true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 94953931 /api/authorship/94953931 Kállai-Szabó, Nikolett [Kállai-Szabó, Nikolett (Gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 2 0.125 false false false Author 10020629 /api/author/10020629 Kállai-Szabó Nikolett (Gyógyszertechnológia) Kállai-Szabó Nikolett true 10020629 true Kállai-Szabó Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 94953932 /api/authorship/94953932 Fülöp, Viktor [Fülöp, Viktor (Gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 3 0.125 false false false Author 10044643 /api/author/10044643 Fülöp Viktor (Gyógyszertechnológia) Fülöp Viktor true 10044643 true Fülöp Viktor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 94953933 /api/authorship/94953933 Jakab, Géza [Jakab, Géza (gyógyszerészet), szerző] Gyógyszerészeti Intézet (SE / GYTK) 4 0.125 false false false Author 10055817 /api/author/10055817 Jakab Géza (gyógyszerészet) Jakab Géza true 10055817 true Jakab Géza true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 94953934 /api/authorship/94953934 Gordon, Péter [Gordon, Péter (Hibaanalitika), szerző] Elektronikai Technológia Tanszék (BME / VIK) 5 0.125 false false false Author 10013580 /api/author/10013580 Gordon Péter (Hibaanalitika) Gordon Péter true 10013580 true Gordon Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 94953935 /api/authorship/94953935 Kállai-Szabó, Barnabás [Kállai-Szabó, Barnabás (Gyógyszertechnológia), szerző] 6 0.125 false false false Author 10027949 /api/author/10027949 Kállai-Szabó Barnabás (Gyógyszertechnológia) Kállai-Szabó Barnabás true 10027949 true Kállai-Szabó Barnabás true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 94953936 /api/authorship/94953936 Balogh, Emese [Bertalanné Balogh, Emese (Gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 7 0.125 false false false Author 10020627 /api/author/10020627 Bertalanné Balogh Emese (Gyógyszertechnológia) Bertalanné Balogh Emese true 10020627 true Balogh Emese true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 94953937 /api/authorship/94953937 Antal, István ✉ [Antal, István (Gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 8 0.125 false true true Author 10020626 /api/author/10020626 Antal István (Gyógyszertechnológia) Antal István true 10020626 true Antal István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 18261541 /api/publicationidentifier/18261541 DOI: 10.1208/s12249-020-01902-x PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1208/s12249-020-01902-x https://doi.org/10.1208/s12249-020-01902-x false true PublicationIdentifier 18350531 /api/publicationidentifier/18350531 WoS: 000605609200002 PlainSource 1 /api/publicationsource/1 WoS 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(2021) AAPS PHARMSCITECH 1530-9932 1530-9932 22 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061230"><a href="/gui2/?type=authors&mode=browse&sel=10061230" target="_blank">Sántha Konrád (<span class="authorship-author-name">Sántha Konrád</span> <span class="authorAux-mtmt"> gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020629"><a href="/gui2/?type=authors&mode=browse&sel=10020629" target="_blank">Kállai-Szabó Nikolett (<span class="authorship-author-name">Kállai-Szabó Nikolett</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044643"><a href="/gui2/?type=authors&mode=browse&sel=10044643" target="_blank">Fülöp Viktor (<span class="authorship-author-name">Fülöp Viktor</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055817"><a href="/gui2/?type=authors&mode=browse&sel=10055817" target="_blank">Jakab Géza (<span class="authorship-author-name">Jakab Géza</span> <span class="authorAux-mtmt"> gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013580"><a href="/gui2/?type=authors&mode=browse&sel=10013580" target="_blank">Gordon Péter (<span class="authorship-author-name">Gordon Péter</span> <span class="authorAux-mtmt"> Hibaanalitika</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Villamosmérnöki és Informatikai Kar">VIK</span>/Elektronikai Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027949"><a href="/gui2/?type=authors&mode=browse&sel=10027949" target="_blank">Kállai-Szabó Barnabás (<span class="authorship-author-name">Kállai-Szabó Barnabás</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020627"><a href="/gui2/?type=authors&mode=browse&sel=10020627" target="_blank">Balogh Emese (<span class="authorship-author-name">Bertalanné Balogh Emese</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020626"><a href="/gui2/?type=authors&mode=browse&sel=10020626" target="_blank">Antal István ✉ (<span class="authorship-author-name">Antal István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31793659" target="_blank">Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies</a></div> <div> <span class="journal-title">AAPS PHARMSCITECH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1530-9932">1530-9932</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1530-9932">1530-9932</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">1</span> <span class="page"> Paper 14. 10 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1208/s12249-020-01902-x" target="_blank" href="https://doi.org/10.1208/s12249-020-01902-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000605609200002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000605609200002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85098265109" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85098265109"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33377174" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33377174&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Agronomy and Crop Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aquatic Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ecology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ecology, Evolution, Behavior and Systematics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 8 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31793659&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31793659</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (KFI_16-1-2017-0025) Támogató: NKFIH, (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2022.05.31. 14:59 Berhidi Anna (SE_KK_Admin5_BA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7, Budapest, 1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, 1111, Hungary ViteCer Ltd., Ipartelepi Str. 8/b, Cegléd, 2700, Hungary Cited By :3 Export Dat...</pre> </div></div>