(Open access funding provided by Semmelweis University)
Szakterületek:
Farmakológia és gyógyszerészet
Orvos- és egészségtudomány
Most of the commercially available pharmaceutical products for oral
administration route are marketed in the tablet dosage forms. However, compression
of
multiparticulate systems is a challenge for the pharmaceutical research and industry,
especially if the individual unit is a coated particle, as the release of the active
ingredient
depends on the integrity of the coating. In the present study, polymer-coated pellets
tableted
with different types of excipients (powder, granules, pellets) then were investigated
by
various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray;
microCT) imaging methods. The information obtained from the independent evaluation
of
the in vitro drug release profiles model is confirmed by the results obtained by image
analysis,
regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets
were
used for image analysis. The results of this study show that the novel easy-to-use,
fast, and
non-destructive MFX method is a good alternative to the already used microscopic image
analysis methods regarding the characterization of particulates, compressed into tablets.
