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However, compression of\nmultiparticulate systems is a challenge for the pharmaceutical research and industry,\nespecially if the individual unit is a coated particle, as the release of the active ingredient\ndepends on the integrity of the coating. In the present study, polymer-coated pellets tableted\nwith different types of excipients (powder, granules, pellets) then were investigated by\nvarious tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray;\nmicroCT) imaging methods. The information obtained from the independent evaluation of\nthe in vitro drug release profiles model is confirmed by the results obtained by image analysis,\nregardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were\nused for image analysis. 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