https://m2.mtmt.hu/ eng 2026-10-25 09:00 JournalArticle 31781703 VALIDATED true 0 false 2026-10-20T23:27:58.146+0000 2026-05-27T11:15:08.509+0000 2020-12-16T10:27:01.853+0000 true 10055096 Nagy Regina /api/admin/10055096 Admin true 10055096 2026-05-27T11:15:08.822+0000 2026-05-27T11:15:08.822+0000 2022-10-20T15:05:46.357+0000 true 10071714 Lukácsné Varga Judit /api/admin/10071714 Admin true Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2026-04-29T07:40:37.901+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Lovas, Attila Reaction Kinetics Modeling of eHsp70 Induced by Norepinephrine in Response to Exercise Stress true true /api/journal/2107 REVIEWED true false 2107 false 2107 true 0172-4622 1439-3964 Journal FOREIGN 42 6 506 512 506 7 2021 Exercise elicits a systemic adaptation reaction, involving both neuroendocrine and cellular/paracrine stress responses, exemplified by the sympathoadrenergic activity and the release of cellular Hsp70 into the circulation. Regular sports training is known to result in increased fitness. In this study, we characterized the plasma norepinephrine and Hsp70 levels and modeled their relationship in response to exercise stress by bicycle ergometer in 12 trained judoka athletes and in 10 healthy controls. Resting norepinephrine was similar in both groups, whereas Hsp70 was significantly higher in controls compared to athletes. Intense exercise load induced both norepinephrine and Hsp70 elevation. However, both norepinephrine and Hsp70 were significantly lower in athletes compared to the control group. A reaction kinetic model was developed that provided a quantitative description of norepinephrine-facilitated extracellular Hsp70 release, congruent with the experimental data. Our study indicates that exercise-induced norepinephrine and extracellular Hsp70 may be coordinated responses to physiological stress, which are robustly affected by regular sports activity. Funding 1993298 /api/funding/1993298 false true Funding 1993299 /api/funding/1993299 false true Funding 2011483 /api/funding/2011483 false true Funding 2011484 /api/funding/2011484 false true Funding 2011485 /api/funding/2011485 false true true true 2020 true true true false true false PAY 2026-10-21 false 3 0 3 3 0 3 3 2 3 3 3 3 3 3 0 0 3 3 3 3 0 4 4 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 0 0 0 0 2024 0 0 0 0 0 2025 0 1 1 1 1 2026 0 1 1 1 1 Q1 false 10027107,10046700 false false false 2021-01-20T14:03:44.474+0000 Analízis Tanszék (BME / TTK / MI); Egészségtudományi és Sportorvosi Tanszék (MTSE / SETI); Fizioterápiás és Sporttudományi Intézet (PTE / ETK); Geometria Tanszék (BME / TTK / MI); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Küzdősportok Tanszék (MTSE / SI); Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K); Ápolástudományi Tanszék (PTE / ETK / SEÁI); Érsebészeti és Endovaszkuláris Tanszék (SE / AOK / K) 12 108 11 13 0 true 10073918 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 92321684 /api/authorship/92321684 1 0.07692308 true false false Author 10046700 /api/author/10046700 Lovas Attila true 10046700 true Lovas Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94842415 /api/authorship/94842415 2 0.07692308 false false false Author 10011896 /api/author/10011896 Szilágyi Brigitta true 10011896 true Szilágyi Brigitta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92321686 /api/authorship/92321686 3 0.07692308 false false false Author 10027107 /api/author/10027107 Bosnyák Edit DUPLUM true 10027107 true Bosnyák Edit true false false 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/api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94842421 /api/authorship/94842421 8 0.07692308 false false false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94842422 /api/authorship/94842422 9 0.07692308 false false false Author 10022226 /api/author/10022226 Németh Endre true 10022226 true Németh Endre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94842423 /api/authorship/94842423 10 0.07692308 false false false Gilányi Beatrix true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92321694 /api/authorship/92321694 11 0.077 false false true Author 10029296 /api/author/10029296 Krepuska Miklós true 10029296 true Krepuska Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 92321695 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33291181&dopt=Abstract false true Classification 10003 /api/classification/10003 true true Classification 10029 /api/classification/10029 true true SjrRating 11232153 /api/sjrrating/11232153 56 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2732 /api/classificationexternal/2732 true 2732 true Q1 DIRECT true true /api/publication/31781703 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10046700"><a href="/gui2/?type=authors&mode=browse&sel=10046700" target="_blank">Lovas Attila (<span class="authorship-author-name">Lovas Attila</span> <span class="authorAux-mtmt"> matematika</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Natural Sciences">FNS</span>/<span title="Institute of Mathematics">IM</span>/Department of Analysis</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011896"><a href="/gui2/?type=authors&mode=browse&sel=10011896" target="_blank">Szilágyi Brigitta (<span class="authorship-author-name">Szilágyi Brigitta</span> <span class="authorAux-mtmt"> Finsler-geometria</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Natural Sciences">FNS</span>/<span title="Institute of Mathematics">IM</span>/Department of Geometry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027107"><a href="/gui2/?type=authors&mode=browse&sel=10027107" target="_blank">Bosnyák Edit (<span class="authorship-author-name">Bosnyák Edit</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Testnevelési Egyetem">TE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Egészségtudományi és Sportorvosi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002834"><a href="/gui2/?type=authors&mode=browse&sel=10002834" target="_blank">Ács Pongrácz (<span class="authorship-author-name">Ács Pongrác</span> <span class="authorAux-mtmt"> Sport- és egészség-gazdaságtan, sport- és egész...</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Faculty of Health Sciences">FHS</span>/Institute of Physiotherapy and Sport Science</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013349"><a href="/gui2/?type=authors&mode=browse&sel=10013349" target="_blank">Oláh András (<span class="authorship-author-name">Oláh András</span> <span class="authorAux-mtmt"> Egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Faculty of Health Sciences">FHS</span>/<span title="Institute of Basic Health Sciences, Midwifery and Health Visiting">IBHSMHV</span>/Department of Nursing Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026742"><a href="/gui2/?type=authors&mode=browse&sel=10026742" target="_blank">Komka Zsolt (<span class="authorship-author-name">Komka Zsolt</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Testnevelési Egyetem">TE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Egészségtudományi és Sportorvosi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008870"><a href="/gui2/?type=authors&mode=browse&sel=10008870" target="_blank">Tóth Miklós (<span class="authorship-author-name">Tóth Miklós</span> <span class="authorAux-mtmt"> kardiológia, sportorvostan</span>) </a> </span> <span class="author-affil"><span title="Testnevelési Egyetem">TE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Egészségtudományi és Sportorvosi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022226"><a href="/gui2/?type=authors&mode=browse&sel=10022226" target="_blank">Németh Endre (<span class="authorship-author-name">Németh Endre</span> <span class="authorAux-mtmt"> Sporttudomány</span>) </a> </span> <span class="author-affil"><span title="Testnevelési Egyetem">TE</span>/<span title="Sportági Intézet">SI</span>/Küzdősportok Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gilányi Beatrix </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029296"><a href="/gui2/?type=authors&mode=browse&sel=10029296" target="_blank">Krepuska Miklós ✉ (<span class="authorship-author-name">Krepuska Miklós</span> <span class="authorAux-mtmt"> klinikai</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Érsebészeti és Endovaszkuláris Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012506"><a href="/gui2/?type=authors&mode=browse&sel=10012506" target="_blank">Sőti Csaba (<span class="authorship-author-name">Sőti Csaba</span> <span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011801"><a href="/gui2/?type=authors&mode=browse&sel=10011801" target="_blank">Sótonyi Péter (<span class="authorship-author-name">Sótonyi Péter</span> <span class="authorAux-mtmt"> Érsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Érsebészeti és Endovaszkuláris Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31781703" target="_blank">Reaction Kinetics Modeling of eHsp70 Induced by Norepinephrine in Response to Exercise Stress</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF SPORTS MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0172-4622">0172-4622</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1439-3964">1439-3964</a>)</span>: <span class="journal-volume">42</span> <span class="journal-issue">6</span> <span class="page"> pp 506-512 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1055/a-1224-3792" target="_blank" href="https://doi.org/10.1055/a-1224-3792"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000597147500002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000597147500002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85097997951" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85097997951"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33291181" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33291181&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Orthopedics and Sports Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical Therapy, Sports Therapy and Rehabilitation&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Sports Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 3 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31781703&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31781703</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP2015-6) Funder: MTA Lendület, Nemzeti Bionika Program(ED_17-1-2017-0009), (Higher Education Excellence Program of the Ministry of Human Capacities of Budapest University of Technology and Economics (BME FIKP-BIO)), (OTKA K116525) Funder: NKFI, Analitikai és diagnosztikai kutatási kiválósági központ a sportteljesítmény és az egészség szolgá...(GINOP-2.3.2-15-2016-00047) Funder: GINOP </div> <div class="lastModified">Last Modified: 2026.05.27. 13:15 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.04.29. 09:40 Marcell Kovács (MTMT Közp., admin) </div> </div></div>