(Higher Education Excellence Program of the Ministry of Human Capacities of Budapest
University of Technology and Economics (BME FIKP-BIO))
(OTKA K116525) Támogató: NKFI
Analitikai és diagnosztikai kutatási kiválósági központ a sportteljesítmény és az
egészség szolgá...(GINOP-2.3.2-15-2016-00047) Támogató: GINOP
Szakterületek:
Matematika
Statisztika és valószínűség (benne a statisztikai módszerek kutatása; nem tartalmazza
az alkalmazott statisztikai módszereket, amik az adott szakterületek - gazdaságtudomány,
szociológia, stb. - részeinek tekintendők.)
Exercise elicits a systemic adaptation reaction, involving both neuroendocrine and
cellular/paracrine stress responses, exemplified by the sympathoadrenergic activity
and the release of cellular Hsp70 into the circulation. Regular sports training is
known to result in increased fitness. In this study, we characterized the plasma norepinephrine
and Hsp70 levels and modeled their relationship in response to exercise stress by
bicycle ergometer in 12 trained judoka athletes and in 10 healthy controls. Resting
norepinephrine was similar in both groups, whereas Hsp70 was significantly higher
in controls compared to athletes. Intense exercise load induced both norepinephrine
and Hsp70 elevation. However, both norepinephrine and Hsp70 were significantly lower
in athletes compared to the control group. A reaction kinetic model was developed
that provided a quantitative description of norepinephrine-facilitated extracellular
Hsp70 release, congruent with the experimental data. Our study indicates that exercise-induced
norepinephrine and extracellular Hsp70 may be coordinated responses to physiological
stress, which are robustly affected by regular sports activity.
