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noninvasive in vivo imaging of alpha(v)beta(3) integrin receptors leading to early detection of tumor cells and hence improving the clinical outcomes. In the present study single vial kit based HYNIC RGD(2) was radiolabeled with Tc-99m and evaluated in patients with breast carcinoma.MethodsRadiolabeling was performed via bifunctional chelator method. Tc-99m 1110-2960 MBq (30-80 mCi) was added to the HYNIC-RGD(2) vial. The reaction mixture was heated for 20 minutes at 100 degrees C. After performing the quality checks, whole-body planar imaging was performed in 20 patients at 2-2.5 h post i.v. injection of 555-740 MBq (15-20 mCi) of the radiotracer.ResultsRadiolabeling yield of >= 98% was observed in all the formulations. Quality control tests indicated the suitability of radiopharmaceutical for intravenous administration. Physiological uptake of Tc-99m HYNIC-RGD(2) was observed in the nasopharynx, salivary glands, liver, spleen, and intestine. Good uptake of radiotracer was observed in breast lesions of 18 patients. Two patients were observed to be negative. Increased uptake was also seen in metastatic sites in two patients and in lymph nodes in three patients. Scintigraphy findings were in corroboration with pathological observations.ConclusionThe single vial cold kit based radiolabeling of Tc-99m HYNIC-RGD(2) is facile leading to its easy availability. Tc-99m HYNIC-RGD(2) is a promising radiopharmaceutical which can be used for the molecular imaging of angiogenesis in breast carcinoma patients.", "subjects" : [ { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 2816, "link" : "/api/keyword/2816", "label" : "ANGIOGENESIS", "published" : true, "oldId" : 2816, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1011760, "link" : "/api/keyword/1011760", "label" : "breast carcinoma", "published" : true, "oldId" : 1011760, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1123117, "link" : "/api/keyword/1123117", "label" : "α", "published" : true, "oldId" : 1123117, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2231354, "link" : "/api/keyword/2231354", "label" : "Tc-99m HYNIC RGD(2)", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2231355, "link" : "/api/keyword/2231355", "label" : "(v)β", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2231356, "link" : "/api/keyword/2231356", "label" : "(3) integrin", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2020, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2021-10-02", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10994363, "link" : "/api/sjrrating/10994363", "label" : "sjr:Q3 (2020) Scopus - Medicine (miscellaneous) NUCLEAR MEDICINE COMMUNICATIONS 0143-3636", "listPos" : 1321, "rankValue" : 0.74, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2701, "link" : "/api/classificationexternal/2701", "label" : "Scopus - Medicine (miscellaneous)", "published" : true, "oldId" : 2701, "snippet" : true }, "ranking" : "Q3", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q3", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 1, "ownerInstituteCount" : 3, "directInstituteCount" : 0, "authorCount" : 7, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/31741045", "label" : "Vatsa Rakhee et al. 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