{ "labelLang" : "hun", "responseDate" : "2024-03-28 17:02", "content" : { "otype" : "JournalArticle", "mtid" : 31723521, "status" : "VALIDATED", "published" : true, "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2021-11-30T11:52:25.675+0000", "lastModified" : "2021-11-30T11:51:25.632+0000", "created" : "2020-12-08T15:40:26.111+0000", "creator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "lastDuplumOK" : "2022-03-09T22:39:46.570+0000", "lastDuplumSearch" : "2022-03-09T22:39:46.570+0000", "validated" : "2021-11-30T11:51:25.638+0000", "validator" : { "otype" : "Admin", "mtid" : 10051765, "link" : "/api/admin/10051765", "label" : "Fölkerné Csernyik Rita (PTE 4-es admin)", "familyName" : "Fölkerné Csernyik", "givenName" : "Rita", "published" : true, "oldId" : 10051765, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Chan, Ming-Hsien", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 94422449, "link" : "/api/authorship/94422449", "label" : "Chan, Ming-Hsien", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Chan", "givenName" : "Ming-Hsien", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 94422450, "link" : "/api/authorship/94422450", "label" : "Chan, Yung-Chieh", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Chan", "givenName" : "Yung-Chieh", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 94422451, "link" : "/api/authorship/94422451", "label" : "Liu, Ru-Shi ✉", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Liu", "givenName" : "Ru-Shi", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 94422452, "link" : "/api/authorship/94422452", "label" : "Hsiao, Michael ✉", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Hsiao", "givenName" : "Michael", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 18057217, "link" : "/api/publicationidentifier/18057217", "label" : "DOI: 10.2217/nnm-2020-0273", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.2217/nnm-2020-0273", "realUrl" : "https://doi.org/10.2217%2Fnnm-2020-0273", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 18057216, "link" : "/api/publicationidentifier/18057216", "label" : "WoS: 000583306400001", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=@@@&DestApp=WOS", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000583306400001", "realUrl" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000583306400001&DestApp=WOS", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 18057218, "link" : "/api/publicationidentifier/18057218", "label" : "Scopus: 85096884611", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85096884611", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85096884611", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 18057219, "link" : "/api/publicationidentifier/18057219", "label" : "PubMed: 33112189", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "idValue" : "33112189", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33112189&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10007177, "link" : "/api/journal/10007177", "label" : "NANOMEDICINE 1743-5889 1748-6963", "pIssn" : "1743-5889", "eIssn" : "1748-6963", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10007177, "snippet" : true }, "volume" : "15", "issue" : "27", "firstPage" : "2689", "lastPage" : "2705", "firstPageOrInternalIdForSort" : "2689", "pageLength" : 18, "publishedYear" : 2020, "abstractText" : "Aim: To develop a micelle-type nanobubble decorated with fluorescein-5-isothiocyanate-conjugated transferrin, with encapsulation of paclitaxel (PTX@FT-NB) for lung cancer treatment. Materials & methods: PTX@FT-NBs were characterized to determine their physicochemical properties, structural stability and cytotoxicity. Lung cancer cell and mouse xenograft tumor models were used to evaluate the therapeutic effectiveness of PTX@FT-NB. Results: The PTX@FT-NBs not only showed selective targeting to lung cancer cells but also inhibited tumor growth significantly via paclitaxel release. Furthermore, paclitaxel-induced microtubule stabilization demonstrated the release of the drug from PTX@FT-NB in the targeted tumor cell both in vitro and in vivo. Conclusion: PTX@FT-NB has the potential as an anticancer nanocarrier against lung cancer cells because of its specific targeting and better drug delivery capacity.", "subjects" : [ { "otype" : "Classification", "mtid" : 11058, "link" : "/api/classification/11058", "label" : "Környezeti biotechnológia", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 11077, "link" : "/api/classification/11077", "label" : "Nanotechnológia", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 6493, "link" : "/api/keyword/6493", "label" : "PACLITAXEL", "published" : true, "oldId" : 6493, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1003970, "link" : "/api/keyword/1003970", "label" : "TRANSFERRIN", "published" : true, "oldId" : 1003970, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1627486, "link" : "/api/keyword/1627486", "label" : "lung cancer cells", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1696104, "link" : "/api/keyword/1696104", "label" : "Nanobubble", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1956113, "link" : "/api/keyword/1956113", "label" : "microtubule stabilization", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2020, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : false, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2021-11-30", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10779928, "link" : "/api/sjrrating/10779928", "label" : "sjr:Q1 (2020) Scopus - Development NANOMEDICINE 1743-5889 1748-6963", "listPos" : 42, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 3303, "link" : "/api/classificationexternal/3303", "label" : "Scopus - Development", "published" : true, "oldId" : 3303, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2021-11-29T11:51:25.299+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 5, "ownerInstituteCount" : 41, "directInstituteCount" : 0, "authorCount" : 4, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/31723521", "label" : "Chan Ming-Hsien et al. A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy. (2020) NANOMEDICINE 1743-5889 1748-6963 15 27 2689-2705", "template" : "