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Box 24923, Kuwait; email: ludmil.benov@ku.edu.kw \n Chemicals/CAS: chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; fumarate hydratase, 9032-88-6; glucose 6 phosphate dehydrogenase, 37259-83-9, 9001-40-5; methylene blue, 61-73-4; nitroreductase, 9037-41-6; oxygen, 7782-44-7; superoxide, 11062-77-4; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; Bacterial Proteins; Chloramphenicol; Escherichia coli Proteins; Forkhead Transcription Factors; fumarase C; Fumarate Hydratase; Glucosephosphate Dehydrogenase; Methylene Blue; NF-E2-Related Factor 2; Reactive Oxygen Species; SoxR protein, Bacteria; SoxS protein, E coli; Superoxide Dismutase; Superoxides; Trans-Activators; Transcription Factors \n Funding details: Kuwait University, KU, MB01/18 \n Funding text 1: This work was supported by Kuwait University [grant number MB01/18 ].", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-11-05T22:49:00.520+0000", "lastModified" : "2020-12-06T16:45:41.190+0000", "created" : 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Because MB is redox-active, its biological activities have been attributed to transfer of electrons, generation of reactive oxygen species, and antioxidant action. Results of this study show that MB is more toxic to a superoxide dismutase-deficient Escherichia coli mutant than to its SOD-proficient parent, which indicates that superoxide anion radical is involved. Incubation of E. coli with MB induced the enzymes fumarase C, SOD, nitroreductase A, and glucose-6-phosphate dehydrogenase, all controlled by the soxRS regulon. Induction of these enzymes was prevented by blocking protein synthesis with chloramphenicol and was not observed when soxRS-negative mutants were incubated with MB. These results show that MB is capable of inducing the soxRS regulon of E. coli, which plays a key role in protecting bacteria against oxidative stress and redox-cycling compounds. Irrespective of the abundance of heme-containing proteins in living cells, which are preferred acceptors of electrons from the reduced form of MB, reduction of oxygen to superoxide radical still takes place. Induction of the soxRS regulon suggests that in humans, beneficial effects of MB could be attributed to activation of redox-sensitive transcription factors like Nrf2 and FoxO. 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