MiR-125b-2-3p associates with prognosis of ccRCC through promoting tumor metastasis via targeting EGR1

Meng, Xiangyu; Liu, Kaitai; Xiang, Zhenfei; Yu, Xiao; Wang, Ping ✉; Ma, Qi ✉

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 1943-8141 12 (9) pp. 5575-5585 2020
  • SJR Scopus - Clinical Biochemistry: Q1
Azonosítók
Szakterületek:
    Clear cell renal cell carcinoma (ccRCC) is an aggressive tumor with frequent metastatic rate. In order to explore the mechanisms, we determined the roles of miR-125b-2-3p in metastatic ccRCC progression. In the study, both clinical and experimental evidences supported the critical role of miR-125b-2-3p in accelerating ccRCC metastasis. Elevated miR-125b-2-3p expression correlated with lymphatic invasion, distant metastasis and poor survival. Functional study showed that high miR-125b-2-3p expression significantly increased ccRCC cell migration in vitro and lung metastasis in vivo. Furthermore, we demonstrated that miR-125b-2-3p directly targeted EGR1, and miR-125b-2-3p accelerated ccRCC cell migration through down-regulating EGR1. Taken together, this study demonstrated that miR-125b-2-3p associates with ccRCC prognosis via promoting tumor metastasis through targeting EGR1.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-05-15 01:53