https://m2.mtmt.hu/ eng 2026-09-22 15:46 JournalArticle 3170378 VALIDATED true Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :4 Export Date: 30 August 2019 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :4 Export Date: 31 August 2019 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :4 Export Date: 2 September 2019 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 6 November 2019 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 12 February 2020 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Funding Agency and Grant Number: Kutatoegyetemi es Kivalosagi EMMI tamogatas [29-39-0T147]; OTKA-PDOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [112118]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; A tehetseg ertekenek kibontakoztatasa a Szegedi Tudomanyegyetem kivalosaga erdekeben [TAMOP-4.2.2.B-15/1/KONV-2015-0006]; National Research, Development and Innovation Office grant [GINOP-2.3.2-15-2016-00020]; EU ITN aDDRess consortium [316390] Funding text: We thank Gabriella Pankotai-Bodo for discussion and revisions. We also thank Gyulane Okros for help with U2OS cells and Edina Pataki for technical assistance. This work was supported by Kutatoegyetemi es Kivalosagi EMMI tamogatas [29-39-0T147], OTKA-PD [112118], the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences and 'A tehetseg ertekenek kibontakoztatasa a Szegedi Tudomanyegyetem kivalosaga erdekeben' [TAMOP-4.2.2.B-15/1/KONV-2015-0006] and the National Research, Development and Innovation Office grant GINOP-2.3.2-15-2016-00020. A. Gy. was funded by EU ITN aDDRess consortium (GA number: 316390). Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 29 August 2020 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 30 August 2020 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 10 January 2021 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Funding details: Seventh Framework Programme, FP7, 316390 Funding details: Hungarian Scientific Research Fund, OTKA, 112118 Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 11 January 2021 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Funding details: Seventh Framework Programme, FP7, 316390 Funding details: Hungarian Scientific Research Fund, OTKA, 112118 Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 13 January 2021 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, University of SzegedHungary; email: pankotai@bio.u-szeged.hu Funding details: Seventh Framework Programme, FP7, 316390 Funding details: Hungarian Scientific Research Fund, OTKA, 112118 Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :5 Export Date: 13 March 2021 Correspondence Address: Pankotai, T.; Department of Biochemistry and Molecular Biology, Hungary; email: pankotai@bio.u-szeged.hu Funding details: Seventh Framework Programme, FP7, 316390 Funding details: Hungarian Scientific Research Fund, OTKA, 112118 0 2018-07-17T22:22:02.000+0000 false 3170378 2026-08-28T07:14:09.337+0000 2024-02-09T07:50:47.886+0000 2017-01-20T12:41:58.000+0000 true 10019401 Pankotai Tibor /api/author/10019401 Author true 10019401 2024-02-09T07:50:48.229+0000 2024-02-09T07:50:48.229+0000 2018-01-24T12:17:02.000+0000 true 10058176 Nagyné Tari Emese /api/admin/10058176 Admin true 10058176 2020-04-08T10:41:25.072+0000 true 10026258 Nemesvári Zoltánné /api/admin/10026258 Admin true 10026258 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Borsos, BN Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 7 40960 40960 11 2017 The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells. Our data demonstrate that upon transcription elongation blockage, p53 is associated with genes that have not been reported as its direct targets. p53 could be co-immunoprecipitated with active forms of DNA-directed RNA polymerase II subunit 1 (RPB1), highlighting its association with the elongating RNA polymerase II. During a normal transcription cycle, p53 and RPB1 are localised at distinct regions of selected non-canonical p53 target genes and this pattern of localisation was changed upon blockage of transcription elongation. Additionally, transcription elongation blockage induced the proteasomal degradation of RPB1. 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/api/sjrrating/10716649 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/3170378 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10049721"><a href="/gui2/?type=authors&mode=browse&sel=10049721" target="_blank">Borsos BN (<span class="authorship-author-name">Borsos Barbara Nikolett</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029158"><a href="/gui2/?type=authors&mode=browse&sel=10029158" target="_blank">Huliak I (<span class="authorship-author-name">Huliák Ildikó</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048472"><a href="/gui2/?type=authors&mode=browse&sel=10048472" target="_blank">Majoros H (<span class="authorship-author-name">Majoros Hajnalka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019402"><a href="/gui2/?type=authors&mode=browse&sel=10019402" target="_blank">Ujfaludi Z (<span class="authorship-author-name">Újfaludi Zsuzsanna</span> <span class="authorAux-mtmt"> molekuláris biológia, molekuláris pathologia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gyenis A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pukler P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000502"><a href="/gui2/?type=authors&mode=browse&sel=10000502" target="_blank">Boros IM (<span class="authorship-author-name">Boros Imre Miklós</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Biochemistry; <span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019401"><a href="/gui2/?type=authors&mode=browse&sel=10019401" target="_blank">Pankotai T ✉ (<span class="authorship-author-name">Pankotai Tibor</span> <span class="authorAux-mtmt"> molekuláris patológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3170378" target="_blank">Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">7</span> <span class="page"> Paper 40960. 11 p. </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/srep40960" target="_blank" href="https://doi.org/10.1038/srep40960"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000392298900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000392298900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85010289373" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85010289373"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="28102346" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28102346&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="12780" target="_blank" href="http://publicatio.bibl.u-szeged.hu/12780"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 7 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3170378&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3170378</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3170378</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/3170378/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2024.02.09. 08:50 Ágnes Belházyné Szombathelyi (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, 6726, Hungary Department of Molecular Genetics, Erasmus University Medical Centre, Rotterdam, PO Box 2040CA 3000, Netherlands Institute of Biochemistry, Biological Research Centre, Szeged, 6726, Hungary Cited By :4 Export...</pre> </div></div>