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Simultaneous models for work and heat exchanger network (WHEN) synthesis often derive from heat integration (HI) frameworks. However, it can be noted that simultaneous optimization models for WHI are considerably more complex to solve than in the HI case. The design of efficient pressure manipulation routes (i.e., allocation and sizing of compression and expansion machinery) in process streams prior to heat exchange match allocation can make the optimization procedure more efficient. This work proposes a systematic procedure based on a model that employs Pinch Analysis concepts for defining these routes based on capital and operating cost targets. The solution approach is a hybrid meta-heuristic method based on Simulated Annealing (SA) and Particle Swarm Optimization (PSO). The obtained routes are then converted into a HI problem by fixing pressure manipulation unit sizes. The detailed HI solution is finally transferred into a WHI optimization model as initial design. 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