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Funding Agency and Grant Number: National Key Research and Development Program of Nano Science and Technology of China [2017YFA0205902]; NSFC [61527815, 61960206012, 61975206, 61971400, 61973292, 61775216, 61771452]; Key Research Programs of Frontier Sciences, CAS [QYZDJ-SSW-SYS015]
Funding text: This research was sponsored by the National Key Research and Development Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (nos. 61527815, 61960206012, 61975206, 61971400, 61973292, 61775216, and 61771452), and the Key Research Programs (QYZDJ-SSW-SYS015) of Frontier Sciences, CAS.
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Dai, Yuchuan
CB1-Antibody Modified Liposomes for Targeted Modulation of Epileptiform Activities Synchronously Detected by Microelectrode Arrays
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Temporal lobe epilepsy (TLE) is a focal, recurrent, and refractory neurological disorder. Therefore, precisely targeted treatments for TLE are greatly needed. We designed anti-CB1 liposomes that can bind to CB1 receptors in the hippocampus to deliver photocaged compounds (ruthenium bipyridine triphenylphosphine gamma-aminobutyric acid, RuBi-GABA) in the TLE rats. A 16-channel silicon microelectrode array (MEA) was implanted for simultaneously monitoring electrophysiological signals of neurons. The results showed that anti-CB1 liposomes were larger in size and remained in the hippocampus longer than unmodified liposomes. Following the blue light stimulation, the neural firing rates and the local field potentials of hippocampal neurons were significantly reduced. It is indicated that RuBi-GABA was enriched near hippocampal neurons due to anti-CB1 liposome delivery and photolyzed by optical stimulation, resulting dissociation of GABA to exert inhibitory actions. Furthermore, K-means cluster analysis revealed that the firing rates of interneurons were decreased to a greater extent than those of pyramidal neurons, which may have been a result of the uneven diffusion of RuBi-GABA due to liposomes binding to CB1. In this study, we developed a novel, targeted method to regulate neural electrophysiology in the hippocampus of the TLE rat using antibody-modified nanoliposomes, implantable MEA, and photocaged compounds. This method effectively suppressed hippocampal activities during seizure ictus with high spatiotemporal resolution, which is a crucial exploration of targeted therapy for epilepsy.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Dai, Yuchuan </span> <span class="author-type"> </span> ; <span class="author-name" > Song, Yilin </span> <span class="author-type"> </span> ; <span class="author-name" > Xie, Jingyu </span> <span class="author-type"> </span> ; <span class="author-name" > Xiao, Guihua </span> <span class="author-type"> </span> ; <span class="author-name" > Li, Xuanyu </span> <span class="author-type"> </span> ; <span class="author-name" > Li, Ziyue </span> <span class="author-type"> </span> ; <span class="author-name" > Gao, Fei </span> <span class="author-type"> </span> ; <span class="author-name" > Zhang, Yu </span> <span class="author-type"> </span> ; <span class="author-name" > He, Enhui </span> <span class="author-type"> </span> ; <span class="author-name" > Xu, Shengwei </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;31683878" mtid="31683878" target="_blank">CB1-Antibody Modified Liposomes for Targeted Modulation of Epileptiform Activities Synchronously Detected by Microelectrode Arrays</a></div> <div class="pub-info"> <span class="journal-title">ACS APPLIED MATERIALS & INTERFACES</span> <span class="journal-volume">12</span> : <span class="journal-issue">37</span> <span class="page"> pp. 41148-41156. , 9 p. </span> <span class="year">(2020)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1021/acsami.0c13372" target="_blank" href="https://doi.org/10.1021/acsami.0c13372"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000572965700017" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000572965700017"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85091191417" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85091191417"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32809788" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32809788&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:31683878 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Dai Yuchuan
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;
<span class="author-name" >Song Yilin
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;
<span class="author-name" >Xie Jingyu
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;
<span class="author-name" >Xiao Guihua
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<span class="author-name" >Li Xuanyu
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<span class="author-name" >Li Ziyue
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;
<span class="author-name" >Gao Fei
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;
<span class="author-name" >Zhang Yu
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;
<span class="author-name" >He Enhui
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;
<span class="author-name" >Xu Shengwei
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;
<span class="author-name" >Wang Yun
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;
<span class="author-name" >Zheng Wenfu
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;
<span class="author-name" >Jiang Xingyu
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;
<span class="author-name" >Qi Zhimei
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;
<span class="author-name" >Meng Dongdong
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;
<span class="author-name" >Fan Zhongwei
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;
<span class="author-name" >Cai Xinxia ✉
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;31683878" target="_blank">CB1-Antibody Modified Liposomes for Targeted Modulation of Epileptiform Activities Synchronously Detected by Microelectrode Arrays</a></div> <div> <span class="journal-title">ACS APPLIED MATERIALS & INTERFACES</span>
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 31683878</span>
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Key Research and Development Program of Nano Science and Technology of China [2017YFA0205902]; NSFC [61527815, 61960206012, 61975206, 61971400, 61973292, 61775216, 61771452]; Key Research Programs of Frontier Sciences, CAS [QYZDJ-SSW-SYS015]
Funding text: This research was sponsored by the National Key Research and Development Program of Nan...</pre>
</div></div>