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Objective: Evaluation of international observations involving Hungarian patients, and establishing the D-dimer level elevation as a positive predictive marker for case fatality. Methods: Therefore these authors have elaborated the data of 51 patients positive for SARS-CoV-2 confirmed by RT-PCR in a retrospective study. Biostatistical methods used: binary logistic regression. Evaluated parameters: medians between deaths and survivors, odds ratio calculation between deaths and survivors. Results: Of the 51 patients 13 died within 2 weeks of hospitalization. We found that the traditional D-dimer positivity determined at a cut-off value of 0.5 mu g/ml FEU had low predictive value for lethality (0.36). Using the predictive value, the age-standardized D-dimer cut-off value, the odds ratio increased. When the raw concentration values were compared between the survival and non-survival group, there were sharp differences. The median value at survival was 0.65 mu g/ml FEU, otherwise the concerned median at lethality was 2.21 (p = 0.001). We also examined if the D-dimer reached or exceeded 4 times the cut-off, furthermore, what the risk was for case fatality. Logistic regression coefficient was 1.64 (p = 0,00183); odds ratio = 5.17 (CI 95% = 1.32-20.22). Another option was to compare the age of survived and dead patients for odds of lethality. As only 1 patient died below 80 years, the authors calculated the odds of age beyond 80 for lethality. The concerned odds ratio was 20.7 (CI 95% = 2.41-175.5). Conclusion: D-dimer marked elevation and risk for lethality seemed to be relevant. On the other hand, the collinearity between aging and D-dimer elevation is a confounding bias. 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