https://m2.mtmt.hu/ eng 2026-05-25 05:48 JournalArticle 31662756 VALIDATED true Institute of Enzymology, Research Centre for Natural SciencesBudapest 1117, Hungary Department of Molecular Medicine, Scripps Research Institute, Jupiter, FL 33458, United States Department of Medical Chemistry, Semmelweis University Medical SchoolBudapest 1085, Hungary Export Date: 16 November 2020 0 false 2026-05-20T09:22:20.034+0000 2024-01-09T11:10:33.288+0000 2020-11-16T15:20:16.577+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin true 10035718 2026-04-28T12:56:05.860+0000 2024-01-09T11:10:33.672+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true 2024-01-08T08:54:03.688+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Kudlik, G. Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 21 21 8117 8117 28 2020 Scaffold proteins are typically thought of as multi-domain "bridging molecules." They serve as crucial regulators of key signaling events by simultaneously binding multiple participants involved in specific signaling pathways. In the case of epidermal growth factor (EGF)-epidermal growth factor receptor (EGFR) binding, the activated EGFR contacts cytosolic SRC tyrosine-kinase, which then becomes activated. This process leads to the phosphorylation of SRC-substrates, including the tyrosine kinase substrates (TKS) scaffold proteins. The TKS proteins serve as a platform for the recruitment of key players in EGFR signal transduction, promoting cell spreading and migration. The TKS4 and the TKS5 scaffold proteins are tyrosine kinase substrates with four or five SH3 domains, respectively. Their structural features allow them to recruit and bind a variety of signaling proteins and to anchor them to the cytoplasmic surface of the cell membrane. Until recently, TKS4 and TKS5 had been recognized for their involvement in cellular motility, reactive oxygen species-dependent processes, and embryonic development, among others. However, a number of novel functions have been discovered for these molecules in recent years. In this review, we attempt to cover the diverse nature of the TKS molecules by discussing their structure, regulation by SRC kinase, relevant signaling pathways, and interaction partners, as well as their involvement in cellular processes, including migration, invasion, differentiation, and adipose tissue and bone homeostasis. We also describe related pathologies and the established mouse models. 2020 true true true false false GOLD 2026-05-20 true https://doi.org/10.3390/ijms21218117 33 0 33 28 6 32 33 28 32 33 33 28 28 28 5 0 33 28 33 28 0 12 12 Folyóiratcikk Journal Article 24 30 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 3 2 3 2 2022 0 5 4 5 4 2023 0 6 5 6 5 2024 0 8 6 8 6 2025 0 7 7 7 7 2026 0 4 4 4 4 D1 false false false false 2020-12-10T13:05:49.832+0000 Enzimológiai Intézet (TTK); Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I) 8 31 2 9 0 true 10003134 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 94046586 /api/authorship/94046586 1 0.11111111 true false false Author 10043361 /api/author/10043361 Kudlik Gyöngyi true 10043361 true Kudlik G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046587 /api/authorship/94046587 2 0.11111111 false false false Author 10076635 /api/author/10076635 Takács Tamás true true Takács T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046588 /api/authorship/94046588 3 0.11111111 false false false Radnai L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046589 /api/authorship/94046589 4 0.11111111 false false false Author 10073233 /api/author/10073233 Kurilla Anita true true Kurilla A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046590 /api/authorship/94046590 5 0.11111111 false false false Author 10048288 /api/author/10048288 Szeder Bálint true 10048288 true Szeder B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046591 /api/authorship/94046591 6 0.11111111 false false false Author 10057970 /api/author/10057970 Koprivanacz Kitti true 10057970 true Koprivanacz K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046592 /api/authorship/94046592 7 0.11111111 false false false Author 10068032 /api/author/10068032 Merő Balázs László true true Merő B.L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046593 /api/authorship/94046593 8 0.11111111 false false false Author 10000649 /api/author/10000649 Buday László true 10000649 true Buday L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94046594 /api/authorship/94046594 9 0.11111111 false true false Author 10000695 /api/author/10000695 Vas Virág true 10000695 true Vas V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 17881651 /api/publicationidentifier/17881651 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms21218117 https://doi.org/10.3390/ijms21218117 false true PublicationIdentifier 17932491 /api/publicationidentifier/17932491 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000589137700001 https://www.webofscience.com/wos/woscc/full-record/000589137700001 false true PublicationIdentifier 17881650 /api/publicationidentifier/17881650 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85095584182 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85095584182 false true PublicationIdentifier 19241073 /api/publicationidentifier/19241073 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 33143131 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33143131&dopt=Abstract false true Classification 10575 /api/classification/10575 true true Keyword 2702 /api/keyword/2702 true 2702 true Keyword 1027681 /api/keyword/1027681 true 1027681 true Keyword 1030392 /api/keyword/1030392 true 1030392 true Keyword 1104152 /api/keyword/1104152 true 1104152 true Keyword 1108260 /api/keyword/1108260 true 1108260 true Keyword 1264233 /api/keyword/1264233 true 1264233 true Keyword 1264234 /api/keyword/1264234 true 1264234 true Keyword 1597481 /api/keyword/1597481 true true Keyword 2189054 /api/keyword/2189054 true true SjrRating 10770268 /api/sjrrating/10770268 57 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1706 /api/classificationexternal/1706 true 1706 true D1 DIRECT true true /api/publication/31662756 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043361"><a href="/gui2/?type=authors&mode=browse&sel=10043361" target="_blank">Kudlik G. (<span class="authorship-author-name">Kudlik Gyöngyi</span> <span class="authorAux-mtmt"> molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076635"><a href="/gui2/?type=authors&mode=browse&sel=10076635" target="_blank">Takács T. (<span class="authorship-author-name">Takács Tamás</span> <span class="authorAux-mtmt"> Természettudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Radnai L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073233"><a href="/gui2/?type=authors&mode=browse&sel=10073233" target="_blank">Kurilla A. (<span class="authorship-author-name">Kurilla Anita</span> <span class="authorAux-mtmt"> Biológiai tudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048288"><a href="/gui2/?type=authors&mode=browse&sel=10048288" target="_blank">Szeder B. (<span class="authorship-author-name">Szeder Bálint</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057970"><a href="/gui2/?type=authors&mode=browse&sel=10057970" target="_blank">Koprivanacz K. (<span class="authorship-author-name">Koprivanacz Kitti</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068032"><a href="/gui2/?type=authors&mode=browse&sel=10068032" target="_blank">Merő B.L. (<span class="authorship-author-name">Merő Balázs László</span> <span class="authorAux-mtmt"> Enzimológia, biokémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000649"><a href="/gui2/?type=authors&mode=browse&sel=10000649" target="_blank">Buday L. (<span class="authorship-author-name">Buday László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000695"><a href="/gui2/?type=authors&mode=browse&sel=10000695" target="_blank">Vas V. (<span class="authorship-author-name">Vas Virág</span> <span class="authorAux-mtmt"> Őssejt biológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31662756" target="_blank">Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">21</span> <span class="journal-issue">21</span> <span class="page"> Paper 8117. 28 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms21218117" target="_blank" href="https://doi.org/10.3390/ijms21218117"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000589137700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000589137700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85095584182" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85095584182"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33143131" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33143131&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 33</span> | Independent citation: 28 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 28 | Number of citations in Scopus:&nbsp;32 | WoS/Scopus assigned:&nbsp;33 | Number of citations with DOI:&nbsp;33 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31662756&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31662756</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2024.01.09. 12:10 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.01.08. 09:54 György Wolf (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Enzymology, Research Centre for Natural SciencesBudapest 1117, Hungary Department of Molecular Medicine, Scripps Research Institute, Jupiter, FL 33458, United States Department of Medical Chemistry, Semmelweis University Medical SchoolBudapest 1085, Hungary Export Date: 16 November 2020</pre> </div></div>