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      <comment>Heart and Vascular Centre, Semmelweis University, Budapest, Hungary            
            Department of Cardiac Surgery, University of Halle, Halle, Germany            
            Institute of Surgical Research, University of Szeged, Szeged, Hungary            
            MTA–SZTE Research Group on Photoacoustic Spectroscopy, University of Szeged, Szeged, Hungary            
            MTA–SZTE Research Group on Photoacoustic Spectroscopy, University of Szeged, Szeged, Hungary            
            Cited By :2            
            Export Date: 23 January 2023            
            CODEN: JHLTE            
            Correspondence Address: Hartmann, P.; Institute of Surgical Research, H-6724 Szeged Pulz u. 1., Hungary</comment>
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      <abstractText>BACKGROUND: Maintenance of cell viability during cold storage is a key issue in organ transplantation. Methane (CH4) bioactivity has recently been recognized in ischemia/reperfusion conditions; we therefore hypothesized that cold storage in CH4-enriched preservation solution can provide an increased defense against organ dysfunction during experimental heart transplantation (HTX).

METHODS: The hearts of donor Lewis rats were stored for 60 minutes in cold histidine-tryptophan-ketoglutarate (Custodiol [CS]) or CH4-saturated CS solution (CS-CH4) (n = 12 each). Standard heterotopic HTX was performed, and 60 minutes later, the left ventricular (LV) pressure-volume relationships LV systolic pressure (LVSP), systolic pressure increment (dP/dtmax), diastolic pressure decrement, and coronary blood flow (CBF) were measured. Tissue samples were taken to detect proinflammatory parameters, structural damage (by light microscopy), endoplasmic reticulum (ER) stress, and apoptosis markers (CCAAT/enhancer binding protein [C/EBP] homologous protein, GRP78, glycogen synthase kinase-3 beta, very low-density lipoprotein receptor, caspase 3 and 9, B-cell lymphoma 2, and bcl-2-like protein 4), whereas mitochondrial functional changes were analyzed by high-resolution respirometry.

RESULTS: LVSP and dP/dtmax increased significantly at the largest pre-load volumes in CS-CH4 grafts as compared with the CS group (114.5 +/- 16.6 mm Hg vs 82.8 +/- 4.6 mm Hg and 3,133 +/- 430 mm Hg/s vs 1,739 +/- 169 mm Hg/s, respectively); the diastolic function and CBF (2.4 +/- 0.4 ml/min/g vs 1.3 +/- 0.3 ml/min/g) also improved. Mitochondrial oxidative phosphorylation capacity was more preserved (58.5 +/- 9.4 pmol/s/ml vs 27.7 +/- 6.6 pmol/s/ml), and cytochrome c release was reduced in CS-CH4 storage. Signs of HTX-caused myocardial damage, level of ER stress, and the transcription of proapoptotic proteins were significantly lower in CS-CH4 grafts.

CONCLUSION: The addition of CH4 during 1 hour of cold storage improved early in vitro graft function and reduced mitochondrial dysfunction and activation of inflammation. Evidence shows that CH4 reduced ER stress-linked proapoptotic signaling. (C) 2020 International Society for Heart and Lung Transplantation. All rights reserved.</abstractText>
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      <label>Benke Kálmán et al. Methane supplementation improves graft function in experimental heart transplantation. (2021) JOURNAL OF HEART AND LUNG TRANSPLANTATION 1053-2498 1557-3117 40 3 183-192</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10048080&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10048080&quot; target=&quot;_blank&quot;&gt;Benke, Kálmán&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10075283&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10075283&quot; target=&quot;_blank&quot;&gt;Jász, Dávid Kurszán&lt;sup&gt;*&lt;/sup&gt;&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10058052&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10058052&quot; target=&quot;_blank&quot;&gt;Szilágyi, Ágnes Lilla&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; 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mtid=&quot;31662130&quot; target=&quot;_blank&quot;&gt;Methane supplementation improves graft function in experimental heart transplantation&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;journal-title&quot;&gt;JOURNAL OF HEART AND LUNG TRANSPLANTATION&lt;/span&gt; &lt;span class=&quot;journal-volume&quot;&gt;40&lt;/span&gt; : &lt;span class=&quot;journal-issue&quot;&gt;3&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; pp. 183-192. , 10 p. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2021)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-end&quot;&gt;&lt;div class=&quot;identifier-list&quot;&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_PAY&quot; title=&quot; Fizetős &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1016/j.healun.2020.11.003&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1016/j.healun.2020.11.003&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; 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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Városmajori Szív- és Érgyógyászati Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;Városmajori Szív- és Érgyógyászati Klinika&quot;&gt;VAROSMAJOR_SZÍVÉRGYÓGY&lt;/span&gt;/Kardiológia Központ - Kardiológiai Tanszék&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;1403806&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=1403806&quot; target=&quot;_blank&quot;&gt;Szabó Gábor
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Szabó Gábor&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Kvantumelektronika&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Szegedi Tudományegyetem&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Természettudományi és Informatikai Kar&quot;&gt;TTIK&lt;/span&gt;/&lt;span title=&quot;Fizikai Intézet&quot;&gt;FI&lt;/span&gt;/Optikai és Kvantumelektronikai Tanszék&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10002691&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002691&quot; target=&quot;_blank&quot;&gt;Merkely Béla
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Merkely Béla Péter&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Kardiológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Városmajori Szív- és Érgyógyászati Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;Városmajori Szív- és Érgyógyászati Klinika&quot;&gt;VAROSMAJOR_SZÍVÉRGYÓGY&lt;/span&gt;/Kardiológiai tanszék - Vascularis Neurológia Tanszéki Csoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;Városmajori Szív- és Érgyógyászati Klinika&quot;&gt;VAROSMAJOR_SZÍVÉRGYÓGY&lt;/span&gt;/Kardiológia Központ - Kardiológiai Tanszék; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;Városmajori Szív- és Érgyógyászati Klinika&quot;&gt;VAROSMAJOR_SZÍVÉRGYÓGY&lt;/span&gt;/Sportorvostan Tanszék&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10027484&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10027484&quot; target=&quot;_blank&quot;&gt;Hartmann Petra
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Hartmann Petra&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; traumatológia, kísérletes sebészet&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Szegedi Tudományegyetem&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Szent-Györgyi Albert Orvostudományi Kar&quot;&gt;SZAOK&lt;/span&gt;/Sebészeti Műtéttani Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10003467&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10003467&quot; target=&quot;_blank&quot;&gt;Boros Mihály ✉
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Boros Mihály&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; keringéskutatás&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Szegedi Tudományegyetem&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Szent-Györgyi Albert Orvostudományi Kar&quot;&gt;SZAOK&lt;/span&gt;/Sebészeti Műtéttani Intézet&lt;/span&gt;

				    &lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;31662130&quot; target=&quot;_blank&quot;&gt;Methane supplementation improves graft function in experimental heart transplantation&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;JOURNAL OF HEART AND LUNG TRANSPLANTATION&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1053-2498&quot;&gt;1053-2498&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1557-3117&quot;&gt;1557-3117&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;40&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;3&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	pp 183-192
			
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2021)&lt;/span&gt;  
    &lt;/div&gt;
&lt;div class=&quot;pub-footer&quot;&gt;
    

	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv:
			Angol
		 |  &lt;/span&gt;

	&lt;span class=&quot;identifiers&quot;&gt;
						&lt;span class=&quot;id identifier oa_PAY&quot; title=&quot;	Fizetős
&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;10.1016/j.healun.2020.11.003&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1016/j.healun.2020.11.003&quot;&gt;
									DOI
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;000630490000003&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/000630490000003&quot;&gt;
									WoS
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;85096984026&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-85096984026&quot;&gt;
									Scopus
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;33277170&quot; target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=33277170&amp;dopt=Abstract&quot;&gt;
									PubMed
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_GREEN&quot; title=&quot;	Green
&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;20988&quot; target=&quot;_blank&quot; href=&quot;http://publicatio.bibl.u-szeged.hu/20988&quot;&gt;
									SZTE Publicatio
							&lt;/a&gt;
						&lt;/span&gt;
	&lt;/span&gt;


	&lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Pulmonary and Respiratory Medicine&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Surgery&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Transplantation&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
    &lt;/div&gt;&lt;/OnlyViewableByAuthor&gt;


	&lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt;
		&lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 13&lt;/span&gt;
		| Független: 8
		| Függő: 5
		| Nem jelölt: 0
		| WoS jelölt: 11 
		|  Scopus jelölt:&amp;nbsp;12 
		|  WoS/Scopus jelölt:&amp;nbsp;13 
		|  DOI jelölt:&amp;nbsp;13 
		
	&lt;/div&gt;
    
    
	&lt;div class=&quot;publication-citation&quot;&gt;
		&lt;a target=&quot;_blank&quot; href=&quot;/api/publication?cond=citations.related;eq;31662130&amp;sort=publishedYear,desc&amp;sort=title&quot;&gt;
			Idézett közlemények száma: 8
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	&lt;/div&gt;



    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 31662130&lt;/span&gt;
    | &lt;span class=&quot;status-data status-VALIDATED&quot;&gt; 	Egyeztetett
  &lt;/span&gt;
        
	
	
Forrás	 Idéző
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk
			( Szakcikk
			
			)
		&lt;/span&gt;
      		| &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt;
	| &lt;span class=&quot;publication-sourceOfData&quot;&gt;RIS-GS&lt;/span&gt;
&lt;/div&gt;

&lt;div class=&quot;funder&quot;&gt; (K120232) Támogató: NKFIA,    National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH,    (GINOP-2.3.2-15-2016-00015) Támogató: GINOP,    (TUDFO/47138-1/2019-ITM) Támogató: ITM,    (3.6.2-16-2017-0006) Támogató: EFOP   &lt;/div&gt;
&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2024.09.16. 09:20 Balázs Ádámné (SZTE admin5 TTIK Fizikai Intézet)
&lt;/div&gt;


        &lt;div class=&quot;lockedBy&quot;&gt;Központi kezelésű 2025.02.25. 11:17  Kovács Marcell (MTMT Közp., admin)
        &lt;/div&gt;


	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Heart and Vascular Centre, Semmelweis University, Budapest, Hungary            
            Department of Cardiac Surgery, University of Halle, Halle, Germany            
            Institute of Surgical Research, University of Szeged, Szeged, Hungary            
            MTA–SZTE Research Group on Photoacoustic Spectroscopy, University of Szeged, Szeged, Hungary            
            MTA...&lt;/pre&gt;

&lt;/div&gt;&lt;/div&gt;</template2>
    </publication>
  </content>
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