Overview

Studies in Complement swiftly progressed over the years to yield knowledge that paved the way to the current boom in the interest in Innate Immunity. Complement research generated novel therapeutics that successfully underwent clinical trials, demonstrating that this filed is among the most advanced in biomedical research. Today, we have a novel appreciation of the Complement System that comprises more than 50 fluid and membrane-associated proteins and functions to secure antimicrobial immunity, efficient removal of soluble immune complexes, and tissue regeneration to ensure homeostasis. © 2014 Springer Science+Business Media, New York.