https://m2.mtmt.hu/ hun 2026-05-01 08:07 JournalArticle 31643621 VALIDATED true Funding Agency and Grant Number: Cardior Pharmaceuticals GmbH Funding text: The study was supported by Cardior Pharmaceuticals GmbH. 0 false 2026-04-23T10:03:03.729+0000 2022-01-07T12:49:16.014+0000 2020-10-29T09:10:12.960+0000 true 10063433 Buzási Éva /api/admin/10063433 Admin true 10063433 2024-05-26T07:02:30.615+0000 2021-03-10T13:54:15.398+0000 true 10074697 Polgár Klaudia /api/admin/10074697 Admin true 2021-10-07T10:23:54.818+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Batkai, Sandor CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure true true /api/journal/1482 REVIEWED true false 1482 false 1482 true 0195-668X 1522-9645 Journal FOREIGN 42 2 192 201 ehaa791 192, ehaa791 10 2021 Cardiac miR-132 activation leads to adverse remodelling and pathological hypertrophy. CDR132L is a synthetic lead-optimized oligonucleotide inhibitor with proven preclinical efficacy and safety in heart failure (HF) early after myocardial infarction (MI), and recently completed clinical evaluation in a Phase 1b study (NCT04045405). The aim of the current study was to assess safety and efficacy of CDR132L in a clinically relevant large animal (pig) model of chronic heart failure following MI.In a chronic model of post-MI HF, slow-growing pigs underwent 90 min left anterior descending artery occlusion followed by reperfusion. Animals were randomized and treatment started 1-month post-MI. Monthly intravenous (IV) treatments of CDR132L over 3 or 5 months (3× or 5×) were applied in a blinded randomized placebo-controlled fashion. Efficacy was evaluated based on serial magnetic resonance imaging, haemodynamic, and biomarker analyses. The treatment regime provided sufficient tissue exposure and CDR132L was well tolerated. Overall, CDR132L treatment significantly improved cardiac function and reversed cardiac remodelling. In addition to the systolic recovery, diastolic function was also ameliorated in this chronic model of HF.Monthly repeated dosing of CDR132L is safe and adequate to provide clinically relevant exposure and therapeutic efficacy in a model of chronic post-MI HF. CDR132L thus should be explored as treatment for the broad area of chronic heart failure. true INTERNATIONAL 2020 true true true false true false GOLD 2026-04-23 true https://doi.org/10.1093/eurheartj/ehaa791 113 3 113 97 3 113 113 113 72 113 113 97 97 97 16 0 113 97 113 97 0 2 2 Folyóiratcikk Journal Article 24 113 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 14 10 14 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true Keyword 1013889 /api/keyword/1013889 true 1013889 true Keyword 1063918 /api/keyword/1063918 true 1063918 true Keyword 1143904 /api/keyword/1143904 true 1143904 true Keyword 1512289 /api/keyword/1512289 true true Keyword 1832633 /api/keyword/1832633 true true SjrRating 11227891 /api/sjrrating/11227891 9 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/31643621 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Batkai Sandor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Genschel Celina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Viereck Janika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rump Steffen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bär Christian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Borchert Tobias </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Traxler Denise </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Riesenhuber Martin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spannbauer Andreas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukovic Dominika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zlabinger Katrin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hašimbegović Ena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Winkler Johannes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032242"><a href="/gui2/?type=authors&mode=browse&sel=10032242" target="_blank">Garamvölgyi Rita (<span class="authorship-author-name">Garamvölgyi Rita</span> <span class="authorAux-mtmt"> Állatorvoslás</span>) </a> </span> <span class="author-affil"><span title="Kaposvári Egyetem">KE</span>/<span title="Agrár- és Környezettudományi Kar">AKK</span>/Diagnosztikai és Onkoradiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neitzel Sonja </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gyöngyösi Mariann </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Thum Thomas </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31643621" target="_blank">CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure</a></div> <div> <span class="journal-title">EUROPEAN HEART JOURNAL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0195-668X">0195-668X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1522-9645">1522-9645</a>)</span>: <span class="journal-volume">42</span> <span class="journal-issue">2</span> <span class="page"> pp 192-201 Paper ehaa791. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/eurheartj/ehaa791" target="_blank" href="https://doi.org/10.1093/eurheartj/ehaa791"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000613792800014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000613792800014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85098536587" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85098536587"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33089304" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33089304&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 113</span> | Független: 97 | Függő: 16 | Nem jelölt: 0 | WoS jelölt: 113 | Scopus jelölt:&nbsp;72 | WoS/Scopus jelölt:&nbsp;113 | DOI jelölt:&nbsp;113 (Nem nyilvános:&nbsp;3) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31643621&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31643621</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Utolsó módosítás: 2022.01.07. 13:49 Áts József (ÁtsJ adm2-3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Cardior Pharmaceuticals GmbH Funding text: The study was supported by Cardior Pharmaceuticals GmbH.</pre> </div></div>