Today, insulin hypersensitivity reactions are rare side effects of insulin therapy.
In two-thirds of the suspected insulin allergy cases, the clinical symptoms are not
related to insulin. The authors report the case of a 64-year-old female patient, by
whom lymphocyte tarnsformation test (LIT) has been used to elucidate the background
of allergic symptoms developed during insulin therapy. The performed LTT did not support
hypersensitivity to insulin, however, the positive protamine test raised the suspicion
of fish allergy. Complementary immunoserology also highlighted the coexistence of
previously unrevealed thyroid disease. To our knowledge, this is the first documented
case report in Hungary that attempts to address the real cause of a suspected hypersensitivity
reaction to insulin by using LTT.
