Glaucoma, a well-defined group of progressive optic neuropathies is one of the leading
causes of irreversible blindness worldwide. In order to stop or slow down the progression
of glaucomatous vision deterioration, intraocular pressure reduction by medical, laser
or surgical treatment is needed. To ensure that treatment is efficient and tailored
to the actual needs both cross sectional evaluation of disease severity and measurement
of rate of progression are essential. Currently staging and progression are investigated
with visual field and retinal thickness measurements. Perimetry, however, is influenced
by several biological factors which are not related to glaucoma, and the use of retinal
thinning is limited by floor effect. Therefore, clinical application of optical retinal
coherence tomography angiography, a new and rapidly developing noninvasive measurement
of the capillary perfusion in the various retinal layers, respectively, is now in
the focus of clinical glaucoma research. This comprehensive review summarizes the
current knowledge on one of the most important research areas in optical coherence
tomography angiography in glaucoma, the relationship between retinal capillary perfusion
and the spatially corresponding visual field threshold sensitivity.
