Background: Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia
with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors
and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional
decline in activities of daily living. We examined the association between baseline
hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. Materials
& methods: 12 HSv were computed from structural magnetic resonance images using Freesurfer
6.0 segmentation. Functional decline was assessed using the rapid disability rating
scale score. Linear regressions were conducted. Results: In AD, HSv were smaller bilaterally.
However, HSv were not associated with functional decline. Conclusion: Functional decline
does not depend on HSv in mild AD and DLB.
